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Cited by 130Neuroscience and Neural EngineeringVagus Nerve Stimulation ResearchNeurological disorders and treatments

A characterization of the effects on neuronal excitability due to prolonged microstimulation with chronically implanted microelectrodes

McCreery, D.B., Yuen, T.G.H., Agnew, W.F., Bullara, L.A.·1997·IEEE Transactions on Biomedical Engineering
DOI 10.1109/10.634645
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Abstract

Localized, long-lasting stimulation-induced depression of neuronal excitability (SIDNE) is a consequence of prolonged, high-frequency microstimulation in the central nervous system (CNS). It represents a persisting refractory state in the neurons and axons near the stimulating microelectrode, that occurs in the absence of histologically detectable tissue injury. It does not involve a change in synaptic efficacy and, in this respect, it differs from the more familiar phenomenon of long-term depression (LTD). Although SIDNE is ultimately reversible (after several days), it must be taken into account in the design of neural prostheses based on microstimulation in the central nervous system and in animal studies that require prolonged microstimulation in the CNS. In this study, we have characterized the phenomenon, using as the paradigm, iridium microelectrodes implanted chronically in the cat's posteroventral cochlear nucleus. Although the SIDNE may persist for several days after the end of the stimulation protocol, it does not become more severe from day to day when the stimulation protocol is repeated on successive days. The severity of the SIDNE is strongly dependent upon both the instantaneous frequency and the duty cycle of the electrical stimulation. The character of the SIDNE, including its localization to the immediate vicinity of the stimulating microelectrodes, suggests that the phenomenon is a direct consequence of the prolonged electrical excitation of the neurons close to the microelectrode. The problem of designing microstimulation systems that allow high-frequency stimulation of a neural substrate, while minimizing SIDNE are discussed.

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  • McCreery et al. suggested the use of a parameter called 'average frequency', equal to stimulus frequency times the percentage of effective stimulation time, as a means of predicting SIDNE, which is considered an early stage of neural damage.

    “McCreery et al. suggested the use of a parameter they called ‘average frequency’, equal to stimulus frequency times the percentage of effective stimulation time, as a means of predicting SIDNE, which is considered an early stage of neural damage [94].”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [94]

  • When stimulating the cochlear nucleus in cats for 7 h at higher overall average frequencies above 100 Hz, McCreery et al. noted an increase in the threshold of the evoked response proportional to the average frequency, indicating this parameter is more meaningful than either frequency or percentage of effective stimulation time alone.

    “When stimulating the cochlear nucleus in cats for 7 h at higher overall average frequencies above 100 Hz, they noted an increase in the threshold of the evoked response proportional to the average frequency, indicating this parameter is more meaningful than either frequency or percentage of effective stimulation time alone.”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [94]

  • In stimulation of the cochlear nucleus of guinea pigs, McCreery et al. showed that frequencies up to 100 Hz caused no damage nor SIDNE after 7 h of continuous stimulation while higher frequencies of 250 and 500 Hz were damaging.

    “In stimulation of the cochlear nucleus of guinea pigs, McCreery et al. showed that frequencies up to 100 Hz caused no damage nor stimulation-induced depression of neuronal excitability (SIDNE) after 7 h of continuous stimulation while higher frequencies of 250 and 500 Hz were damaging [94].”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [94]

  • McCreery et al. showed a correlation between the level of SIDNE and the pulse frequency and stimulation duration, respectively, but no injury could be detected on histological evaluation.

    “They showed a correlation between the level of SIDNE and the pulse frequency and stimulation duration, respectively, but no injury could be detected on histological evaluation [94].”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [94]

  • A large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s.

    “Consequently, a large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s [43–45, 62–64, 75, 92, 94, 96, 99, 100].”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [94]

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Authors
McCreery, D. B., Yuen, T. G. H., Agnew, W. F., & Bullara, L. A.
Affiliations
Huntington Medical Research Institutes (US)
ORCID
McCreery, D.B.
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
1997
Volume
44
Issue
10
Pages
931-939
ISSN
0018-9294 (ISSN-L)
DOI
10.1109/10.634645
OpenAlex
W2135479849
Cited by
130
References
11
Citations by year
2026: 7 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations
  • IEEE Transactions on Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01dc002400-000)
  • National Institute on Deafness and Other Communication Disorders (N01-DC-5-2105, N01-DC2400)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
high-frequency electrical stimulation, chronic electrode implantation, posteroventral cochlear nucleus, duty cycle, stimulation frequency, neural prostheses, long-term depression
MeSH terms
Animals, Cats, Cochlear Implants, Electrodes, Implanted, Equipment Design, Evaluation Studies as Topic, Iridium, Microelectrodes, Neurons, Time Factors, Cochlear Nucleus

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