The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.
A 0.013 ${\hbox {mm}}^{2}$, 5 $\mu\hbox{W}$, DC-Coupled Neural Signal Acquisition IC With 0.5 V Supply
Abstract
We present an area-efficient neural signal-acquisition system that uses a digitally intensive architecture to reduce system area and enable operation from a 0.5 V supply. The architecture replaces ac coupling capacitors and analog filters with a dual mixed-signal servo loop, which allows simultaneous digitization of the action and local field potentials. A noise-efficient DAC topology and an compact, boxcar sampling ADC are used to cancel input offset and prevent noise folding while enabling “per-pixel” digitization, alleviating system-level complexity. Implemented in a 65 nm CMOS process, the prototype occupies 0.013 mm2while consuming 5 μW and achieving 4.9 μVrms of input-referred noise in a 10 kHz bandwidth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, modern circuit designs [77, 92] and IC fabrication technologies [18, 86] have resulted in innovative designs, enabling designers to relax such compromises.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]
In the citing paper
“CNS amplifiers have also been developed that can acquire both types of signals, separately filtering, amplifying and outputting each signal type [46, 86, 100].”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]
In the citing paper
“Recently, Muller et al. [86] introduced the power efficiency factor (PEF), which takes into account both the operating current and the supply voltage and therefore provides a better comparison of the amplifier’s performance.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]
Citations
Cites
Operation and modeling of the MOS transistor
Tsividis, Y. (1987) · Cited by 3,162
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078
Brain–machine interfaces: past, present and future
Lebedev, M. A., & Nicolelis, M. A. L. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.004 · Cited by 1,875
A low-power integrated circuit for a wireless 100-electrode neural recording system.
Harrison, R. R., Watkins, P. T., Kier, R. J., Lovejoy, R. O., Black, D. J., Greger, B., & Solzbacher, F. (2007) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2006.886567 · Cited by 782
A Low-Power Integrated Circuit for a Wireless 100-Electrode Neural Recording System
Harrison, R. R., Watkins, P., Kier, R. J., Lovejoy, R. O., Black, D., Normann, R. A., & Solzbacher, F. (2006) · Digest of technical papers/Digest of technical papers - IEEE International Solid-State Circuits Conference · doi:10.1109/isscc.2006.1696288 · Cited by 728
Impedance Characterization and Modeling of Electrodes for Biomedical Applications
Franks, W., Schenker, I., Schmutz, P., & Hierlemann, A. R. (2005) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2005.847523 · Cited by 660
Emergence of a stable cortical map for neuroprosthetic control
Ganguly, K., & Carmena, J. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000153 · Cited by 578
A micropower low-noise monolithic instrumentation amplifier for medical purposes
Steyaert, M. S. J., & Sansen, W. M. C. (1987) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.1987.1052869 · Cited by 577
0.5-V analog circuit techniques and their application in OTA and filter design
Chatterjee, S., Tsividis, Y., & Kinget, P. R. (2005) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2005.856280 · Cited by 503
An Energy-Efficient Micropower Neural Recording Amplifier
Wattanapanitch, W., Fee, M., & Sarpeshkar, R. (2007) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2007.907868 · Cited by 441
Flagged first, then by citations
1 of the 27 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- xiao, 2010, A 20 <ref_formula><tex Notation="TeX">$\mu{W}$</tex> </ref_formula> neural recording tag with supply-current-modulated AFE in 0.13 <ref_formula> <tex Notation="TeX">$\mu{\hbox {m}}$</tex></ref_formula> CMOS, IEEE Solid-State Circuits Conf Dig Tech Papers, 122
- muller, 2011, A 0.013 <ref_formula><tex Notation="TeX">${\hbox {mm}}^{2}$</tex></ref_formula>, 5 <ref_formula><tex Notation="TeX">$\mu{W}$</tex> </ref_formula>, DC-coupled neural signal acquisition IC with 0.5 V supply, IEEE Solid-State Circuits Conf Dig Tech Papers, 302
Cited by
Sorted by citations
Items 301–338 of 338
Modeling the delay of voltage to time converter in subthreshold region
Zaare, M., & Maymandi‐Nejad, M. (2014) · Iranian Conference on Electrical Engineering · doi:10.1109/iraniancee.2014.6999493
Multi Channel Low-Noise Low-Power Amplifier for Neural Signal Acquisition
Yasuda, Y., & Nakano, N. (2015) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.135.2
In Vivo Exploration of Robust Implantable Devices Constructed From Biocompatible 3C–SiC
Frewin, C. L., Thomas, S. W., Coletti, C., & Saddow, S. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802993-0.00007-1
Reducing the implant footprint: low-area neural recording
Muller, R., Gambini, S., & Rabaey, J. M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139629539.035
Self-citationMultichannel Low‐Noise Low‐Power Amplifier for Neural Signal Acquisition
YASUDA, Y., & Nakano, N. (2016) · Electronics and Communications in Japan · doi:10.1002/ecj.11816
Design and characterization of a 65nm CMOS wireless RFID reader for ECoG tag
Venuto, D. D., & Rabaey, J. M. (2017) · International Workshop on Advances in Sensors and Interfaces (IWASI) · doi:10.1109/iwasi.2017.7974201
Self-citationTime-Based Biomedical Readout in Ultra-Low-Voltage, Small-Scale CMOS Technology
Mohan, R., Zaliasl, S., Hoof, C. A. V., & Helleputte, N. V. (2017) · Springer eBooks · doi:10.1007/978-3-319-61285-0_17
Electrical Biosensors: Biopotential Amplifiers
Zhang, F., Tan, Y., Holleman, J. H., & Otis, B. P. (2019) · Springer eBooks · doi:10.1007/978-1-4614-6623-9_24-1
A 0.4-V 1.9 μ W Amplifier for Low Power Biomedical Applications
Chen, Y., Chen, Y., Li, C., & Guo, Y. (2019) · International Conference on Integrated Circuits and Microsystems (ICICM) · doi:10.1109/icicm48536.2019.8977154
Implantable Brain-Computer Interfaces for Monitoring and Treatment of Neurological Disorders
Kassiri, H., & Genov, R. (2021) · Springer eBooks · doi:10.1007/978-1-4614-6623-9_69-1
Low Area Digital Front-End for Single Lead ECG Acquisition
Neelamsetty, S. K., & Balivada, L. K. (2021) · International Conference on Electrical, Electronics, Communication, Computer and Optimization Techniques (ICEECCOT) · doi:10.1109/iceeccot52851.2021.9708032
Implantable Brain-Computer Interfaces for Monitoring and Treatment of Neurological Disorders
Kassiri, H., & Genov, R. (2022) · Springer eBooks · doi:10.1007/978-1-4614-3447-4_69
Implantable Cardio Technologies: A Review of Integrated Low Noise Amplifiers
Lakshmi, P. V., Musala, S., & Srinivasulu, A. (2022) · doi:10.1002/9781119792581.ch2
Low-power Wearable Healthcare Sensors
Sherratt, R. S., & Dey, N. (2020) · MDPI eBooks · doi:10.3390/books978-3-03936-480-0
Analogue Front-End Design for Neural Recording
Maslik, M., Leene, L. B., & Constandinou, T. G. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_20
A figure of merit for noise power and area optimization of neural amplifiersPreprint
Sharma, S., hande, V. G., & Das, D. M. (2023) · doi:10.36227/techrxiv.22219579
A figure of merit for noise power and area optimization of neural amplifiersPreprint
Sharma, S., hande, V. G., & Das, D. M. (2023) · doi:10.36227/techrxiv.22219579.v1
A figure of merit for noise power and area optimization of neural amplifiersPreprint
Sharma, S., hande, V. G., & Das, D. M. (2023) · doi:10.36227/techrxiv.22219579.v2
Ghafar‐Zadeh, E., Forouhi, S., & Azadmousavi, T. (2024) · Analog circuits and signal processing/Analog circuits and signal processing series · doi:10.1007/978-94-007-0099-4_3
Efficient Bio-Sensing Amplifier Design: A Python Based gm/ID Design Methodology
Srivastava, M., O'Donnell, C., Griffin, B., Cantillon‐Murphy, P., & O’Hare, D. (2024) · IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas61083.2024.10798363
Buhmann, A., Lanniel, A., Hiller, T., Sporer, M., Reich, S., & Ortmanns, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95478-5.00040-6
Assche, J. V., & Gielen, G. E. (2025) · Analog circuits and signal processing/Analog circuits and signal processing series · doi:10.1007/978-3-031-97285-0_2
He, J., Xu, J., & Wang, Y. (2025) · Micromachines · doi:10.3390/mi16101176
Chen, Y., Cao, Y., Li, M., Lin, Q., Huang, K., Tan, Z., Zhao, M., & Song, S. (2025) · doi:10.1109/esserc66193.2025.11214082
Huang, X., Yassin, H. A., Alcazar, B. L., Akhoundi, A., & Muratore, D. G. (2026) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2025.3650066
Feng, C., Tang, J., Chen, L., Mai, S., & Tang, X. (2025) · IEEE International Conference on ASIC (ASICON) · doi:10.1109/asicon66040.2025.11326498
Zhao, L., & Jia, Y. (2026) · Biomedical Engineering Letters · doi:10.1007/s13534-026-00574-z
Ballistocardiography and applications
Cathelain, G. (2020) · doi:10.70675/ae4c68fbz0e3fz4730za7f9za9901e5c70e3
Jeong, K., Livanelioglu, C., Liao, J., Lee, I., & Jang, T. (2026) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2026.3685168 · Cited by 1
Lv, S., Hu, G., Lv, L., Zhang, P., Chen, F., Wen, J., Lu, S., Wang, Z., & Jiang, H. (2026) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas66217.2026.11562444
Zhong, M., Chen, W., Wan, P., Chen, Z., & Liu, X. (2026) · Microelectronics Journal · doi:10.1016/j.mejo.2026.107336
Sharma, S., Shivdeep, S., Hande, V. G., & Das, D. M. (2026) · Integration · doi:10.1016/j.vlsi.2026.102805
Koutsoftidis, S., Gryparis, G., Zajaczkowski, M., Yang, G., Glaros, K. N., Farina, D., & Drakakis, E. M. (2026) · Sensors · doi:10.3390/s26134181
Design of Low Noise Amplifier using NMOS CVF OTA for Neural Recording Applications
Singh, N., Laskar, N. M., Kumar, G., Dhanaji, T. H., & Singh, A. K. (2026) · International Conference on Next Generation Electronics (NELEX) · doi:10.1109/nelex69209.2026.11590824
Yu, I., Yoo, M., Nam, G., Wi, J., Choi, M., Son, M., Jin, D., Lee, E. G., Bin, H., & Ko, H. (2026) · Microelectronics Journal · doi:10.1016/j.mejo.2026.107455
A 0.3-V Bulk-Driven Current-Mode Capacitance Multiplier for Area-Efficient BiomedicalFiltersPreprint
Sala, R. D., Nicolini, G., & Scotti, G. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7505863
Neural Recording and Neural Stimulation Circuits and Systems
Zheng, Y., Hang, D., & Bharadwaj, C. V. G. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8151-5_9
Metadata
- Authors
- Muller, R., Gambini, S., & Rabaey, J. M.
- Affiliations
- University of California, Berkeley (US)
- Venue
- IEEE Journal of Solid-State Circuits
- Published
- 2012-01
- Volume
- 47
- Issue
- 1
- Pages
- 232-243
- ISSN
- 0018-9200 (ISSN-L)
- 1558-173X
- OpenAlex
- W2003444784
- Cited by
- 338
- References
- 27
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 18 · 2023: 21 · 2022: 22 · 2021: 26 · 2020: 26 · 2019: 25 · 2018: 34 · 2017: 28 · 2016: 25 · 2015: 26 · 2014: 26 · 2013: 20 · 2012: 7
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Journal of Solid-State Circuits (publishedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- neural signal acquisition, low-power integrated circuits, local field potentials, digital-to-analog converter, noise folding, low-voltage operation, 65 nm CMOS, area-efficient circuit design
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review