A 0.338cm<formula> <tex>$^{3}$</tex> </formula>, Artifact-Free, 64-Contact Neuromodulation Platform for Simultaneous Stimulation and Sensing
Abstract
Neuromodulation (NM) is the alteration of nervous tissue function through targeted delivery of a stimulus, such as electrical stimulation, into the affected neurological sites in the body. We present a bidirectional NM interface that features 100 mVpp linear input range and ability to sense data concurrent with stimulation (without blanking). The system includes a flexible 8-driver-to-64-contact custom waveform stimulator able to deliver up to 5.1 mA per driver and a 64-contact sensing unit with online blind artifact rejection unit. This artifact rejection unit removes stimulation artifacts from recorded data and allows extraction of neural biomarkers. The NM interface also features an efficient, integrated power management unit that can support various power delivery options. The proposed 64-contact interface satisfies design requirements of human-grade brain implants at unprecedented level of electronic miniaturization compared to state-of-the-art.
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Adaptive filtering is one processing method for artifact removal.
“One processing method is adaptive filtering (Mahajan and Morshed, 2015; Rozgic et al., 2019; Samiei and Hashemi, 2021).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Rozgic et al., 2019
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Advances in Neural Recording and Stimulation Integrated Circuits
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Energy efficient neural stimulator with dynamic supply modulation
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- Authors
- Rozgic, D., Hokhikyan, V., Jiang, W., Akita, I., Basir - Kazeruni, S., Chandrakumar, H., & Markovic, D.
- Affiliations
- University of California, Los Angeles (US)
- National Institute of Advanced Industrial Science and Technology (JP)
- Venue
- IEEE Transactions on Biomedical Circuits and Systems
- Published
- 2018
- Volume
- 13
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1932-4545 (ISSN-L)
- 1940-9990
- OpenAlex
- W2909425830
- Cited by
- 49
- References
- 40
- Citations by year
- 2025: 7 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 3
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- IEEE Transactions on Biomedical Circuits and Systems (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Lawrence Livermore National Laboratory
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Keywords
- neuromodulation, bidirectional neural interface, neural markers, neural implants, power management, electronics miniaturization, neural recording
- MeSH terms
- Calibration, Electric Stimulation, Feedback, Humans, Nerve Tissue, Electric Power Supplies, Semiconductors, Artifacts, Wireless Technology
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