64-Channel UWB Wireless Neural Vector Analyzer SOC With a Closed-Loop Phase Synchrony-Triggered Neurostimulator
Abstract
An ultra wideband (UWB) 64-channel responsive neural stimulator system-on-chip (SoC) is presented. It demonstrates the first on-chip neural vector analyzer capable of wirelessly monitoring magnitude, phase and phase synchronization of neural signals. In a closed-loop, abnormal phase synchrony triggers the programmable-waveform biphasic current-mode neural stimulator. To implement these functionalities, the SoC integrates 64 neural recording amplifiers with tunable switched-capacitor (SC) bandpass filters, 64 multiplying 8-bit SAR ADCs, 64 programmable 16-tap FIR filters, a tri-core CORDIC processor, 64 biphasic current stimulation channels, and a 3.1-10.6 GHz UWB wireless transmitter onto a 4 mm × 3 mm 0.13 μm CMOS die. To minimize both the area and power dissipation of the SoC, the SAR ADC is re-used as a multiplier for FIR filtering and as a DAC and duty cycle controller for the biphasic neural stimulator. The SoC has been validated in the early detection and abortion of seizures in freely moving rodents on-line and in early seizure detection in humans off-line.
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It is common for multiple amplifier channels to share a single ADC or output driver in a time-multiplexed sequence.
“For example, it is common for multiple amplifier channels to share a single ADC or output driver in a time-multiplexed sequence [1, 51, 73, 94].”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [1]
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- Authors
- Abdelhalim, K., Jafari, H. M., Kokarovtseva, L., Velazquez, J. L. P., & Genov, R.
- Affiliations
- University of Toronto (CA)
- ORCID
- Genov, Roman
- Venue
- IEEE Journal of Solid-State Circuits
- Published
- 2013-10
- Volume
- 48
- Issue
- 10
- Pages
- 2494-2510
- ISSN
- 0018-9200 (ISSN-L)
- 1558-173X
- OpenAlex
- W2091665061
- Cited by
- 124
- References
- 40
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 7 · 2018: 15 · 2017: 14 · 2016: 18 · 2015: 12 · 2014: 8
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Journal of Solid-State Circuits (publishedVersion)
- Funders
- CMC Microsystems
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- closed-loop neurostimulation, system-on-chip, FIR filtering, CORDIC processor, seizure detection, epilepsy, CMOS integrated circuit
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