The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats
Abstract
The goal of this study was to design, fabricate, and test arrays of hollow microneedles for minimally invasive and continuous delivery of insulin in vivo. As a simple, robust fabrication method suitable for inexpensive mass production, we developed a modified-LIGA process to micromachine molds out of polyethylene terephthalate using an ultraviolet laser, coated those molds with nickel by electrodepostion onto a sputter-deposited seed layer, and released the resulting metal microneedle arrays by selectively etching the polymer mold. Mechanical testing showed that these microneedles were sufficiently strong to pierce living skin without breaking. Arrays containing 16 microneedles measuring 500 microm in length with a 75 microm tip diameter were then inserted into the skin of anesthetized, diabetic, hairless rats. Insulin delivery through microneedles caused blood glucose levels to drop steadily to 47% of pretreatment values over a 4-h insulin delivery period and were then approximately constant over a 4-h postdelivery monitoring period. Direct measurement of plasma insulin levels showed a peak value of 0.43 ng/ml. Together, these data suggest that microneedles can be fabricated and used for in vivo insulin delivery.
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Cites
McAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859
Self-citationSilicon micromachined hollow microneedles for transdermal liquid transport
Gardeniers, H. J. G. E., Luttge, R., Berenschot, E. J. W., de Boer, M. J., Yeshurun, S. Y., Hefetz, M., van-t Oever, R., & van den Berg, A. (2003) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2003.820293 · Cited by 413
Cited by
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
Precise Microinjection into Skin Using Hollow Microneedles
Wang, P. M., Cornwell, M., Hill, J., & Prausnitz, M. R. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700150 · Cited by 332
Self-citationSuprachoroidal drug delivery to the back of the eye using hollow microneedles
Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0271-y · Cited by 330
Self-citationAdvances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Gill, H. S., & Prausnitz, M. R. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100517 · Cited by 164
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Metadata
- Authors
- Davis, S. P., Martanto, W., Allen, M. G., & Prausnitz, M. R.
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2005-05
- Volume
- 52
- Issue
- 5
- Pages
- 909-915
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2132780556
- Cited by
- 406
- References
- 2
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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