The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats
Abstract
The goal of this study was to design, fabricate, and test arrays of hollow microneedles for minimally invasive and continuous delivery of insulin in vivo. As a simple, robust fabrication method suitable for inexpensive mass production, we developed a modified-LIGA process to micromachine molds out of polyethylene terephthalate using an ultraviolet laser, coated those molds with nickel by electrodepostion onto a sputter-deposited seed layer, and released the resulting metal microneedle arrays by selectively etching the polymer mold. Mechanical testing showed that these microneedles were sufficiently strong to pierce living skin without breaking. Arrays containing 16 microneedles measuring 500 microm in length with a 75 microm tip diameter were then inserted into the skin of anesthetized, diabetic, hairless rats. Insulin delivery through microneedles caused blood glucose levels to drop steadily to 47% of pretreatment values over a 4-h insulin delivery period and were then approximately constant over a 4-h postdelivery monitoring period. Direct measurement of plasma insulin levels showed a peak value of 0.43 ng/ml. Together, these data suggest that microneedles can be fabricated and used for in vivo insulin delivery.
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Citations
Cites
Microneedles for transdermal drug delivery
Prausnitz, M. R. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.023 · Cited by 1,521
Self-citationMicrofabricated Microneedles: A Novel Approach to Transdermal Drug Delivery
Henry, S., McAllister, D. V., Allen, M. G., & Prausnitz, M. R. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980042+ · Cited by 1,346
Self-citation(2010) · Wiley eBooks · doi:10.1002/9780470602638 · Cited by 1,219
Davis, S. P., Landis, B. J., Adams, Z. H., Allen, M. G., & Prausnitz, M. R. (2004) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2003.12.010 · Cited by 934
Self-citationMcAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859
Self-citationLack of Pain Associated with Microfabricated Microneedles
Kaushik, S., Hord, A. H., Denson, D. D., McAllister, D. V., Smitra, S., Allen, M. G., & Prausnitz, M. R. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200102000-00041 · Cited by 576
Self-citationTransdermal Delivery of Insulin Using Microneedles in Vivo
Martanto, W., Davis, S. P., Holiday, N. R., Wang, J., Gill, H. S., & Prausnitz, M. R. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000029282.44140.2e · Cited by 521
Self-citationSilicon micromachined hollow microneedles for transdermal liquid transport
Gardeniers, H. J. G. E., Luttge, R., Berenschot, E. J. W., de Boer, M. J., Yeshurun, S. Y., Hefetz, M., van-t Oever, R., & van den Berg, A. (2003) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2003.820293 · Cited by 413
Mikszta, J. A., Alarcon, J. B., Brittingham, J. M., Sutter, D. E., Pettis, R. J., & Harvey, N. G. (2002) · Nature Medicine · doi:10.1038/nm0402-415 · Cited by 398
Standing, O. (2002) · Cited by 351
Cited by
Microneedles for drug and vaccine delivery
Kim, Y.-C., Park, J.-H., & Prausnitz, M. R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.04.005 · Cited by 1,760
Self-citationLarrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
Microneedles: A New Frontier in Nanomedicine Delivery
Larrañeta, E., McCrudden, M. T. C., Courtenay, A. J., & Donnelly, R. F. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1885-5 · Cited by 339
Precise Microinjection into Skin Using Hollow Microneedles
Wang, P. M., Cornwell, M., Hill, J., & Prausnitz, M. R. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700150 · Cited by 332
Self-citationSuprachoroidal drug delivery to the back of the eye using hollow microneedles
Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0271-y · Cited by 330
Self-citationAdvances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Gill, H. S., & Prausnitz, M. R. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100517 · Cited by 164
Self-citation
Metadata
- Authors
- Davis, S. P., Martanto, W., Allen, M. G., & Prausnitz, M. R.
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2005-05
- Volume
- 52
- Issue
- 5
- Pages
- 909-915
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2132780556
- Cited by
- 406
- References
- 21
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
