The DOI matches its Crossref record; 225 of the 227 references it cites were found in a registry or an index.
Nutritional iron turned inside out: intestinal stress from a gut microbial perspective
Open accessAbstract
Iron is abundantly present on earth, essential for most microorganisms and crucial for human health.Human iron deficiency that is nevertheless highly prevalent in developing regions of the world can be effectively treated by oral iron administration.Accumulating evidence indicates that excess of unabsorbed iron that enters the colonic lumen causes unwanted side effects at the intestinal host-microbiota interface.The chemical properties of iron, the luminal environment and host iron withdrawal mechanisms, especially during inflammation, can turn the intestine in a rather stressful milieu.Certain pathogenic enteric bacteria can, however, deal with this stress at the expense of other members of the gut microbiota, while their virulence also seems to be stimulated in an iron-rich intestinal environment.This review covers the multifaceted aspects of nutritional iron stress with respect to growth, composition, metabolism and pathogenicity of the gut microbiota in relation to human health.We aim to present an unpreceded view on the dynamic effects and impact of oral iron administration on intestinal host-microbiota interactions to provide leads for future research and other applications. Summary and scope of this reviewIron is a highly abundant metal on earth and is vital for virtually all organisms, including most bacterial species.Nonetheless, iron deficiency is the most prevalent human nutrition disorder worldwide and is generally treated by oral iron administration.Notably, accumulating evidence suggests that unabsorbed iron can stimulate growth and virulence of bacterial pathogens in the intestinal environment.Simultaneously, host iron status influences the local defence against pathogens.Salmonella enterica serovar Typhimurium, a highly prevalent intestinal pathogen around the world, is one example of a pathogenic bacterial species that can deal with the stress of iron limitation, iron abundance and host defence factors.It is able to adapt to these environmental triggers and exploit the environment to thrive at the expense of other bacterial species.In this review, we will thoroughly discuss many different factors that are involved in iron-mediated host-pathogen interactions in the intestinal tract at the molecular level.We will first give a concise introduction in gut microbiology and nutritional stress.The central part of this review will present current knowledge about the effects of luminal iron on gut immunology and on the gut microbiota with respect to bacterial composition, pathogenicity and metabolism.These and other factors will also be related to pathogen stress in the gut lumen and are summarised in Fig. 1.Furthermore, we will mostly focus on S. Typhimurium and its ways to deal with environmental stress and to turn the external situation in favour of its own growth and colonisation.Finally, we will place the topics we discussed in the context of serious threats that persist in tropical Africa, such as infectious diarrhoea and S. Typhimurium infection that is often associated with invasive disease in this region. General introduction Gut microbiology and healthThe human gut is the natural habitat for a unique large and dynamic bacterial community that greatly
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In particular, proliferation and activity of the bacterium Escherichia coli is facilitated by the presence of iron in the colonic lumen, suggesting enhanced pathogenicity in the setting of unregulated iron availability.”
From Overview of lunar dust toxicity risk (2022) · cites this paper as [52]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Interestingly, although sufficient iron may be present in the gastrointestinal tract, more specifically the colonic lumen, mostly due to excess dietary iron, it may have limited availability to microbiota. This is due to dietary molecules such as polyphenol and phytate as well as metabolic by-products that sequester available iron (reviewed by Kortman et al., 2014).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Kortman et al., 2014
The cited source says what the claim attributes to it.
In the citing paper
“recent studies suggest that the high availability of iron in the gastrointestinal tract may enhance expression of virulent factors in pathogenic bacteria52.”
From Overview of lunar dust toxicity risk (2022) · cites this paper as [52]
In the citing paper
“It leads to a more diverse oral microbial community [23]”
From High iron-mediated increased oral fungal burden, oral-to-gut transmission, and changes to pathogenicity of Candida albicans in oropharyngeal candidiasis (2022) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Stowman, K. (1949) · The Milbank Memorial Fund Quarterly · doi:10.2307/3348165 · Cited by 2,962
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625
Iron Metabolism in Pathogenic Bacteria
Ratledge, C., & Dover, L. G. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.881 · Cited by 1,539
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509
Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation
Ragsdale, S. W., & Pierce, E. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.08.012 · Cited by 1,409
Zimmermann, M. B., & Hurrell, R. F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61235-5 · Cited by 1,405
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310
Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288
Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271
Weinberg, E. D. (1978) · Microbiological Reviews · doi:10.1128/mmbr.42.1.45-66.1978 · Cited by 1,254
Iron in infection and immunity
Cassat, J. E., & Skaar, E. P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.04.010 · Cited by 1,214
Iron Transport and Storage Proteins
Aisen, P., & Listowsky, I. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002041 · Cited by 1,179
Diarrhoea: why children are still dying and what can be done
Wardlaw, T., Salama, P., Brocklehurst, C., Chopra, M., & Mason, E. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61798-0 · Cited by 1,097
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
Feasey, N., Dougan, G., Kingsley, R. A., Heyderman, R. S., & Gordon, M. A. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61752-2 · Cited by 1,049
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
Perspectives on the use of organic acids and short chain fatty acids as antimicrobials
Ricke, S. C. (2003) · Poultry Science · doi:10.1093/ps/82.4.632 · Cited by 1,032
Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019
Montagné, L., Pluske, J. R., & Hampson, D. J. (2003) · Animal Feed Science and Technology · doi:10.1016/s0377-8401(03)00163-9 · Cited by 999
Sazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970
Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Schlemmer, U., Frølich, W., Prieto, R., & Grases, F. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900099 · Cited by 910
Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868
The role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786
Zoetendal, E. G., Raes, J., van den Bogert, B., Arumugam, M., Booijink, C. C. G. M., Troost, F. J., Bork, P., Wels, M., de Vos, W. M., & Kleerebezem, M. (2012) · The ISME Journal · doi:10.1038/ismej.2011.212 · Cited by 722
Iron and Its Relation to Immunity and Infectious Disease
Oppenheimer, S. J. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.616s · Cited by 695
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692 · cited 1×
“…the evidence for the toxicity of products originated from protein fermentation shown in multiple in vitro studies, we need to note that evidence for the in vivo toxicity is limited and a recent trial did not support a role of protein fermentation in human gut toxicity (Windey et al., 2012a, b).”
Role of iron in regulation of virulence genes
Litwin, C. M., & Calderwood, S. B. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.2.137 · Cited by 651
The iron-oxidizing proteobacteria
Hedrich, S., Schlömann, M., & Johnson, D. B. (2011) · Microbiology · doi:10.1099/mic.0.045344-0 · Cited by 647
Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01281.x · Cited by 632
Jaeggi, T., Kortman, G. A. M., Moretti, D., Chassard, C., Holding, P., Dostal, A., Boekhorst, J., Timmerman, H. M., Swinkels, D. W., Tjalsma, H., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307720 · Cited by 622
Self-citationCowland, J. B., & Borregaard, N. (1997) · Genomics · doi:10.1006/geno.1997.4896 · Cited by 619
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
Thiennimitr, P., Winter, S., Winter, M. G., Byndloss, M. X., Tolstikov, V., Huseby, D. L., Sterzenbach, T., Tsolis, R. M., Roth, J. R., & Bäumler, A. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107857108 · Cited by 611
Intestinal colonization resistance
Lawley, T. D., & Walker, A. W. (2013) · Immunology · doi:10.1111/j.1365-2567.2012.03616.x · Cited by 610
The role of microbiota in infectious disease
Stecher, B., & Hardt, W. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2007.12.008 · Cited by 547
Lack of a role for iron in the Lyme disease pathogen
Posey, J. E., & Gherardini, F. C. (2000) · Science · doi:10.1126/science.288.5471.1651 · Cited by 538
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525
Self-citationZimmermann, M. B., Chassard, C., Rohner, F., N'Goran, E. K., Nindjin, C., Dostal, A., Utzinger, J., Ghattas, H., Lacroix, C., & Hurrell, R. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004564 · Cited by 520
Short-Chain Fatty Acids in the Human Colon: Relation to Gastrointestinal Health and Disease
Mortensen, P. B., & Clausen, M. R. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094568 · Cited by 513
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501
Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora
Miller, T. L., & Wolin, M. J. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.5.1589-1592.1996 · Cited by 481
Bajaj, V., Lucas, R. L., Hwang, C., & Lee, C. A. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.d01-1718.x · Cited by 477
Intestinal microbiota, diet and health
Power, S. E., O'Toole, P. W., Stanton, C., Ross, R. P., & Fitzgerald, G. F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002560 · Cited by 476
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
Donofrio, A. E., Crawford, J. M., Stewart, E. J., Witt, K., Gavrish, E., Epstein, S. S., Clardy, J., & Lewis, K. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.02.010 · Cited by 457
The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacy
Immerseel, F. V., Russell, J. B., Flythe, M. D. D., Gantois, I., Timbermont, L., Pasmans, F., Haesebrouck, F., & Ducatelle, R. (2006) · Avian Pathology · doi:10.1080/03079450600711045 · Cited by 434
Why do bacteria use so many enzymes to scavenge hydrogen peroxide?
Mishra, S., & Imlay, J. A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.04.014 · Cited by 433
Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract
Barman, M., Unold, D., Shifley, K., Amir, E., Hung, K.-C., Bos, N. A., & Salzman, N. H. (2007) · Infection and Immunity · doi:10.1128/iai.01432-07 · Cited by 428
Stecher, B., Chaffron, S., Käppeli, R., Hapfelmeier, S., Freedrich, S., Weber, T. C., Kirundi, J., Suar, M., McCoy, K. D., von Mering, C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000711 · Cited by 427
Iron uptake mechanisms of pathogenic bacteria
Wooldridge, K. G., & WILLIAMS, P. H. (1993) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1993.tb00026.x · Cited by 426
Nielsen, B. S., Borregaard, N., Bundgaard, J. R., Timshel, S., Sehested, M., & Kjeldsen, L. (1996) · Gut · doi:10.1136/gut.38.3.414 · Cited by 422
Kehl-Fie, T. E., Chitayat, S., Hood, M. I., Damo, S., Restrepo, N., Garcia, C., Munro, K. A., Chazin, W. J., & Skaar, E. P. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.07.004 · Cited by 419
Macfarlane, G. T., & Macfarlane, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31822fecfe · Cited by 406
Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Müller, A. J., Heikenwälder, M. F., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1675 · Cited by 394
Wang, X., Ouyang, Y., Liu, J., & Zhao, G. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300278x · Cited by 391
Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors
Figueira, R., & Holden, D. W. (2012) · Microbiology · doi:10.1099/mic.0.058115-0 · Cited by 377
Hantke, K., Nicholson, G., Rabsch, W., & Winkelmann, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737682100 · Cited by 359
Siderophore uptake in bacteria and the battle for iron with the host; a bird’s eye view
Chu, B. C. H., Garcia-Herrero, A., Johanson, T. H., Krewulak, K. D., Lau, C. K. Y., Peacock, R. S., Slavinskaya, Z., & Vogel, H. J. (2010) · BioMetals · doi:10.1007/s10534-010-9361-x · Cited by 352
Vuyst, L. D., & Leroy, F. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.03.003 · Cited by 349
The dynamics of gut‐associated microbial communities during inflammation
Winter, S., Lopez, C. A., & Bäumler, A. J. (2013) · EMBO Reports · doi:10.1038/embor.2013.27 · Cited by 335
Soofi, S., Cousens, S., Iqbal, S. P., Akhund, T., Khan, J., Ahmed, I., Zaidi, A. K., & Bhutta, Z. A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60437-7 · Cited by 330 · cited 2×
“In Pakistan, a significant increase in severe and bloody diarrhoea and respiratory disease was reported, and in Ghana, there was an increased number of hospitalisations that was possibly partly due to diarrhoea (Soofi et al., 2013; Zlotkin et al., 2013).”
BackgroundLiu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328
Self-citationThe Footprints of Gut Microbial–Mammalian Co-Metabolism
Zheng, X., Xie, G., Zhao, A., Zhao, L., Yao, C., Chiu, N. H. L., Zhou, Z., Bao, Y., Jia, W., Nicholson, J. K., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr2007945 · Cited by 321
Contribution of Salmonella typhimurium Virulence Factors to Diarrheal Disease in Calves
Tsolis, R. M., Adams, L. G., Ficht, T. A., & Bäumler, A. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4879-4885.1999 · Cited by 319
Raqib, R., Sarker, P., Bergman, P., Ara, G., Lindh, M., Sack, D. A., Islam, K., Gudmundsson, G. H., Andersson, J., & Agerberth, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602888103 · Cited by 317
Bacterial Mechanisms to Overcome Inhibitory Effects of Dietary Tannins
Smith, A. H., Zoetendal, E. G., & Mackie, R. I. (2005) · Microbial Ecology · doi:10.1007/s00248-004-0180-x · Cited by 314
Effect of iron supplementation on incidence of infectious illness in children: systematic review
Gera, T., & Sachdev, H. P. S. (2002) · BMJ · doi:10.1136/bmj.325.7373.1142 · Cited by 311
Salmonella- the ultimate insider.Salmonellavirulence factors that modulate intracellular survival
Ibarra, J. A., & Steele‐Mortimer, O. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01368.x · Cited by 308
Bachman, M. A., Oyler, J. E., Burns, S. H., Caza, M., Lepine, F. L., Dozois, C. M., & Weiser, J. N. (2011) · Infection and Immunity · doi:10.1128/iai.05114-11 · Cited by 308
Lawley, T. D., Bouley, D. M., Hoy-Schulz, Y. E., Gerke, C., Relman, D. A., & Monack, D. M. (2007) · Infection and Immunity · doi:10.1128/iai.01189-07 · Cited by 303
Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis
Werner, T., Wagner, S. J., Martínez, I., Walter, J., Chang, J.-S., Clavel, T., Kisling, S., Schuemann, K., & Haller, D. (2011) · Gut · doi:10.1136/gut.2010.216929 · Cited by 299
The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria
Behnsen, J., Jellbauer, S., Wong, C. P., Edwards, R. A., George, M. D., Ouyang, W., & Raffatellu, M. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.003 · Cited by 279
Self-citationNyangale, E. P., Mottram, D. S., & Gibson, G. R. (2012) · Journal of Proteome Research · doi:10.1021/pr300637d · Cited by 275
Intestinal antimicrobial peptides during homeostasis, infection, and disease
Muniz, L. R., Knosp, C. A., & Yeretssian, G. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00310 · Cited by 275
P HYSIOLOGY AND M OLECULAR B IOLOGY OF D IETARY I RON A BSORPTION
Miret, S., Simpson, R. J., & McKie, A. T. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073139 · Cited by 274
The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
den Abbeele, P. V., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00270.x · Cited by 273
Iron and infection: the heart of the matter
Bullen, J. J., Rogers, H. J., Spalding, P. B., & Ward, C. G. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.11.010 · Cited by 273
Rist, V. T. S., Weiss, E., Eklund, M., & Mosenthin, R. (2013) · Animal · doi:10.1017/s1751731113000062 · Cited by 269
Out of the iron age: new insights into the critical role of manganese homeostasis in bacteria
Jakubovics, N. S., & Jenkinson, H. F. (2001) · Microbiology · doi:10.1099/00221287-147-7-1709 · Cited by 267
A precious metal: Iron, an essential nutrient for all cells
Cairo, G., Bernuzzi, F., & Recalcati, S. (2006) · Genes & Nutrition · doi:10.1007/bf02829934 · Cited by 261
Iron acquisition in microbial pathogenesis
Payne, S. M. (1993) · Trends in Microbiology · doi:10.1016/0966-842x(93)90036-q · Cited by 259
Th17 Cytokines and the Gut Mucosal Barrier
Blaschitz, C., & Raffatellu, M. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9368-7 · Cited by 258
Self-citationHepcidin in Human Iron Disorders: Diagnostic Implications
Kroot, J. J., Tjalsma, H., Fleming, R. E., & Swinkels, D. W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2009.140053 · Cited by 246
Self-citationLund, E. K., Wharf, S. G., Fairweather‐Tait, S. J., & Johnson, I. T. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.2.250 · Cited by 241
Janakiraman, A., & Slauch, J. M. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01783.x · Cited by 233
Grass, G., Otto, M., Fricke, B., Haney, C. J., Rensing, C., Nies, D. H., & Munkelt, D. (2005) · Archives of Microbiology · doi:10.1007/s00203-004-0739-4 · Cited by 233
Boyer, E., Bergevin, I., Malo, D., Gros, P., & Cellier, M. F. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.6032-6042.2002 · Cited by 230
Dostal, A., Chassard, C., Hilty, F. M., Zimmermann, M. B., Jaeggi, T., Rossi, S., & Lacroix, C. (2011) · Journal of Nutrition · doi:10.3945/jn.111.148643 · Cited by 229
Functions of Bacterial Flagella
Moens, S., & Vanderleyden, J. (1996) · Critical Reviews in Microbiology · doi:10.3109/10408419609106456 · Cited by 215
Adu‐Afarwuah, S., Lartey, A. A., Brown, K. H., Zlotkin, S. H., Briend, A., & Dewey, K. G. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.929 · Cited by 211
Naikare, H. K., Palyada, K., Panciera, R. J., Marlow, D. D., & Stintzi, A. P. (2006) · Infection and Immunity · doi:10.1128/iai.00052-06 · Cited by 204
Motility allows S. Typhimurium to benefit from the mucosal defence
Stecher, B., Barthel, M., Schlumberger, M. C., Haeberli, L., Rabsch, W., Kremer, M., & Hardt, W. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01118.x · Cited by 198
De‐Regil, L. M., Jefferds, M. E., Sylvetsky, A. C., & Dowswell, T. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009085.pub2 · Cited by 197
Kortman, G. A. M., Boleij, A., Swinkels, D. W., & Tjalsma, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029968 · Cited by 195 · cited 5×
“…hand, in vitro studies have shown that freely available iron can directly induce the expression of virulence genes in S. Typhimurium; especially, bacterial adhesion to intestinal epithelial cells seems to be stimulated when iron is highly available (Bjarnason et al., 2003; Kortman et al., 2012).”
BackgroundInfluentialSelf-citationMechanisms of infectious diarrhea
Navaneethan, U., & Giannella, R. A. (2008) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep1264 · Cited by 190
The role of the intestinal microbiota in enteric infection
Sekirov, I., & Finlay, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172742 · Cited by 188
Seril, D. N., Liao, J., Ho, K.-L. K., Warsi, A., Yang, C. S., & Yang, G.-Y. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1015362228659 · Cited by 183
The critical role of iron in host-bacterial interactions.
Payne, S. M., & Finkelstein, R. A. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109062 · Cited by 180
Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse
Tsolis, R. M., Bäumler, A. J., Heffron, F., & Stojiljkovic, I. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4549-4556.1996 · Cited by 174
Bjarnason, J., Southward, C. M., & Surette, M. G. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.16.4973-4982.2003 · Cited by 173
Llamas, M. A., Sparrius, M., Kloet, R., Jiménez, C. R., Vandenbroucke‐Grauls, C. M. J. E., & Bitter, W. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.5.1882-1891.2006 · Cited by 171
Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation
Rivera-Chávez, F., Winter, S., Lopez, C. A., Byndloss, M. X., Winter, M. G., Nuccio, S., Russell, J. M., Laughlin, R. C., Lawhon, S. D., Sterzenbach, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003267 · Cited by 170
Chemistry for an essential biological process: the reduction of ferric iron
Pierre, J. L., Fontecave, M., & Crichton, R. R. (2002) · Biometals · doi:10.1023/a:1020259021641 · Cited by 163
Godinez, I., Raffatellu, M., Chu, H., da Paixão, T. A., Haneda, T., Santos, R. L., Bevins, C. L., Tsolis, R. M., & Bäumler, A. J. (2008) · Infection and Immunity · doi:10.1128/iai.00933-08 · Cited by 163
Self-citationHemodialysis-associated Hemosiderosis in the Era of Erythropoiesis-stimulating Agents: A MRI Study
Rostoker, G., Griuncelli, M., Loridon, C., Couprie, R., Benmaadi, A., Bounhiol, C., Roy, M., Machado, G., Janklewicz, P., Drahi, G., et al. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.01.015 · Cited by 161
Modification of iron regulation by the inflammatory response
WEISS, G. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.001 · Cited by 161
Ellermeier, J. R., & Slauch, J. M. (2008) · Journal of Bacteriology · doi:10.1128/jb.00926-07 · Cited by 160
Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Crichton, R. R. (2009) · Cited by 159
Wang, L., Johnson, E. E., Shi, H. N., Walker, W. A., Wessling-Resnick, M., & Cherayil, B. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2723 · Cited by 159
(2007) · Food and Nutrition Bulletin · doi:10.1177/15648265070284s414 · Cited by 157
Tako, E., Glahn, R. P., Welch, R. M., Lei, X. G., Yasuda, K., & Miller, D. D. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507825128 · Cited by 156
Carrano, C. J., & Raymond, K. N. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00512a047 · Cited by 155
Zlotkin, S., Newton, S., Aimone, A. M., Azindow, I., Amenga-Etego, S., Tchum, K., Mahama, E., Thorpe, K. E., & Owusu-Agyei, S. (2013) · JAMA · doi:10.1001/jama.2013.277129 · Cited by 154
Lee, T. W., Kolber, M. R., Fedorak, R. N., & van Zanten, S. V. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.09.010 · Cited by 153
Boleij, A., & Tjalsma, H. (2012) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2012.00218.x · Cited by 153
Self-citationGodinez, I., Haneda, T., Raffatellu, M., George, M. D., da Paixão, T. A., Rolán, H. G., Santos, R. L., Dandekar, S., Tsolis, R. M., & Bäumler, A. J. (2008) · Infection and Immunity · doi:10.1128/iai.01691-07 · Cited by 153
Self-citationEvaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective
Zhu, A. L., Kaneshiro, M., & Kaunitz, J. D. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1108-6 · Cited by 151
Krebs, N. F., Sherlock, L. G., Westcott, J., Culbertson, D., Hambidge, K. M., Feazel, L. M., Robertson, C. E., & Frank, D. N. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.01.024 · Cited by 149
Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis
Diaz-Ochoa, V. E., Jellbauer, S., Klaus, S., & Raffatellu, M. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00002 · Cited by 129
Self-citationDostal, A., Fehlbaum, S., Chassard, C., Zimmermann, M. B., & Lacroix, C. (2013) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2012.01461.x · Cited by 129
Kaye, P., Abdulla, K., Wood, J., James, P., Foley, S., Ragunath, K., & Atherton, J. C. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03081.x · Cited by 124
Ijssennagger, N., Derrien, M., van Doorn, G. M., Rijnierse, A., van den Bogert, B., Müller, M. M., Dekker, J. P., Kleerebezem, M., & van der Meer, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049868 · Cited by 124
Justino, P. F. C., Melo, L. F. M., Nogueira, A. F., Costa, J. V. G., Silva, L. M. N., Santos, C. M., Mendes, W. D. O., Costa, M. R., Franco, Á. X., Lima, A. Â. M., et al. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513004248 · Cited by 118
Iron requirement and search for siderophores in lactic acid bacteria
Pandey, A., Bringel, F., & Meyer, J.-M. (1994) · Applied Microbiology and Biotechnology · doi:10.1007/bf00173337 · Cited by 117
Stojiljković, I., Cobeljić, M., & Hantke, K. (1993) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1993.tb06082.x · Cited by 111
Crichton, R. R. (2009) · Wiley eBooks · doi:10.1002/9780470010303 · Cited by 111
Prebiotics and Iron Bioavailability—Is There a Connection?
Yeung, C. K., Glahn, R. E., Welch, R. M., & Miller, D. D. (2005) · Journal of Food Science · doi:10.1111/j.1365-2621.2005.tb09984.x · Cited by 105
Salmonella T3SSs: successful mission of the secret(ion) agents
Moest, T., & Méresse, S. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.11.006 · Cited by 105
Ferrioxamine-Mediated Iron(III) Utilization by Salmonella enterica
Kingsley, R. A., Reissbrodt, R., Rabsch, W., Ketley, J. M., Tsolis, R. M., Everest, P. H., Gordon Dougan, B., Bäumler, A. J., Roberts, M., & WILLIAMS, P. H. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.4.1610-1618.1999 · Cited by 105
KANG, D. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.10.008 · Cited by 102
On the Iron Requirement of Lactobacilli Grown in Chemically Defined Medium
Imbert, M., & Blondeau, R. (1998) · Current Microbiology · doi:10.1007/s002849900339 · Cited by 102
Frawley, E. R., Crouch, M.-L. V., Bingham-Ramos, L. K., Robbins, H. F., Wang, W., Wright, G. D., & Fang, F. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218274110 · Cited by 101
Troxell, B., Sikes, M. L., Fink, R. C., Vazquez-Torres, A., Jones-Carson, J., & Hassan, H. M. (2011) · Journal of Bacteriology · doi:10.1128/jb.00942-10 · Cited by 99
Drechsel, H., Thieken, A., Reissbrodt, R., Jung, G., & Winkelmann, G. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.9.2727-2733.1993 · Cited by 98
Petry, N., Egli, I. M., Chassard, C., Lacroix, C., & Hurrell, R. F. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.035717 · Cited by 98
Zaharik, M. L., Vallance, B. A., Puente, J. L., Gros, P., & Finlay, B. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252415599 · Cited by 96
Hultén, L., Gramatkovski, E., Gleerup, A., & Hallberg, L. (1995) · PubMed · Cited by 95
Saini, S., Slauch, J. M., Aldridge, P. D., & Rao, C. V. (2010) · Journal of Bacteriology · doi:10.1128/jb.00624-10 · Cited by 94
Nontyphoidal salmonellosis in Africa
Graham, S. M. (2010) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32833dd25d · Cited by 91
Lund, E. K., Fairweather‐Tait, S. J., Wharf, S. G., & Johnson, I. T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2928 · Cited by 90
Misselwitz, B., Kreibich, S. K., Samuel, R., Stecher, B., Periaswamy, B., & Hardt, W. (2010) · Infection and Immunity · doi:10.1128/iai.00581-10 · Cited by 86
Salmonella Pathogenicity Island 1(SPI-1) at Work
Que, F., Wu, S., & Huang, R. (2013) · Current Microbiology · doi:10.1007/s00284-013-0307-8 · Cited by 84
Effect of pH on bile salt degradation by mixed fecal cultures
Macdonald, I. A., Singh, G., Mahony, D. E., & Meier, C. E. (1978) · Steroids · doi:10.1016/0039-128x(78)90009-0 · Cited by 83
Tompkins, G. R., O’Dell, N. L., Bryson, I. T., & Pennington, C. B. (2001) · Current Microbiology · doi:10.1007/s002840010257 · Cited by 81
Iron Supplementation May Aggravate Inflammatory Status of Colitis in a Rat Model
Reifen, R. M., Matas, Z., Zeidel, L., Berkovich, Z., & Bujanover, Y. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005437331967 · Cited by 80
Low levels of faecal lactobacilli in women with iron-deficiency anaemia in south India
Ramadass, B., Mary, R. R., Chittaranjan, S. P., Hepsiba, J., Devi, R. S., & Ramakrishna, B. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510001637 · Cited by 79
Windey, K., Preter, V. D., Louat, T., Schuit, F. C., Herman, J., Vansant, G. A. A. M., & Verbeke, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052387 · Cited by 79
Noguchi, N., Ohashi, T., Shiratori, T., Narui, K., Hagiwara, T., Ko, M., Watanabe, K., Miyahara, T., Taira, S., Moriyasu, F., et al. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2012-5 · Cited by 79
Diet and faecal flora in the newborn: lactoferrin.
Balmer, S. E., Scott, P., & Wharton, B. A. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.12.1685 · Cited by 78
Feldmann, F., Sorsa, L. J., Hildinger, K., & Schubert, S. (2007) · Infection and Immunity · doi:10.1128/iai.00656-06 · Cited by 78
Ijssennagger, N., Rijnierse, A., de Wit, N. J. W., Boekschoten, M. V., Dekker, J. P., Schonewille, A. J., Müller, M. M., & van der Meer, R. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt084 · Cited by 78
Iron: An emerging factor in colorectal carcinogenesis
Chua, A. C. G. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i6.663 · Cited by 77
Hansen, S. L., Ashwell, M. S., Moeser, A. J., Fry, R. S., Knutson, M. D., & Spears, J. W. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-2341 · Cited by 76
Teixidó, L., Carrasco, B., Alonso, J. C., Barbé, J., & Campoy, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019711 · Cited by 75
Dostal, A., Lacroix, C., Pham, V. T., Zimmermann, M. B., Del’Homme, C., Bernalier‐Donadille, A., & Chassard, C. (2014) · British Journal Of Nutrition · doi:10.1017/s000711451400021x · Cited by 75
Carrier, J. C., Aghdassi, E., Jeejeebhoy, K. N., & Allard, J. P. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-005-0011-7 · Cited by 69
Winter, S., & Bäumler, A. J. (2011) · Gut Microbes · doi:10.4161/gmic.2.1.14911 · Cited by 68
Reduction of iron by extracellular iron reductases: implications for microbial iron acquisition
Cowart, R. E. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00012-7 · Cited by 68
Effect of iron on neonatal gut flora during the first three months of life
Mevissen-Verhage, E. A. E., Marcelis, J. H., Harmsen-Van Amerongen, W. C. M., de Vos, N. M., & Verhoef, J. (1985) · European Journal of Clinical Microbiology · doi:10.1007/bf02013651 · Cited by 68
Müller, A., Heseler, K., Schmidt, S. K., Spekker, K., MacKenzie, C. R., & Däubener, W. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00542.x · Cited by 67
Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity
Wang, L., & Cherayil, B. J. (2009) · Journal of Innate Immunity · doi:10.1159/000210016 · Cited by 66
Dostal, A., Gagnon, M., Chassard, C., Zimmermann, M. B., O’Mahony, L., & Lacroix, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093549 · Cited by 66
Expression of iron absorption genes in mouse large intestine
Takeuchi, K., Bjarnason, I., Laftah, A. H., Latunde-Dada, G. O., Simpson, R. J., & McKie, A. T. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510011489 · Cited by 65
CHIERICO, F. D., Vernocchi, P., Bonizzi, L., Carsetti, R., Castellazzi, A. M., Dallapiccola, B., de Vos, W. M., Guerzoni, M. E., Manco, M., Marseglia, G. L., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.02.018 · Cited by 64
Lee, S. H., Shinde, P., Choi, J., Park, M.-S., Ohh, S. H., Kwon, I. K., Pak, S.-I., & Chae, B. J. (2008) · Biological Trace Element Research · doi:10.1007/s12011-008-8209-5 · Cited by 62
Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation
Cherayil, B. J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20910 · Cited by 61
Pumping iron: mechanisms for iron uptake by Campylobacter
Miller, C. E., Williams, P. H., & Ketley, J. M. (2009) · Microbiology · doi:10.1099/mic.0.032425-0 · Cited by 61
Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents
Ettreiki, C. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i21.2619 · Cited by 58
Diet and faecal flora in the newborn: iron.
Balmer, S. E., & Wharton, B. A. (1991) · Archives of Disease in Childhood · doi:10.1136/adc.66.12.1390 · Cited by 58
Acquisition of iron by the non-siderophore-producing Pseudomonas fragi
Champomier‐Vergès, M., Stintzi, A. P., & Meyer, J. (1996) · Microbiology · doi:10.1099/13500872-142-5-1191 · Cited by 57
Treatment of Anemia in Inflammatory Bowel Disease– Systematic Review and Meta-Analysis
Avni, T., Bieber, A., Steinmetz, T., Leibovici, L., & Gafter‐Gvili, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075540 · Cited by 57
Virulence Inhibition by Zinc in Shiga-Toxigenic Escherichia coli
Crane, J. K., Byrd, W., & Boedeker, E. C. (2011) · Infection and Immunity · doi:10.1128/iai.01099-10 · Cited by 56
Combined Impact of pH and Organic Acids on Iron Uptake by Caco-2 Cells
Salovaara, S., Sandberg, A., & Andlid, T. A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030177n · Cited by 55
Influence of dietary catechols on the growth of enteropathogenic bacteria
Freestone, P. P. E., Walton, N. J., Haigh, R., & Lyte, M. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.07.039 · Cited by 54
Genetic modification of iron metabolism in mice affects the gut microbiota
Buhnik-Rosenblau, K., Moshe-Belizowski, S., Danin-Poleg, Y., & Meyron-Holtz, E. G. (2012) · BioMetals · doi:10.1007/s10534-012-9555-5 · Cited by 53
Role of Catecholate Siderophores in Gram-Negative Bacterial Colonization of the Mouse Gut
Pi, H., Jones, S. A., Mercer, L. E., Meador, J. P., Caughron, J. E., Jordan, L., Newton, S. M., Conway, T., & Klebba, P. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050020 · Cited by 53
Post‐transcriptional regulation of bacterial motility by aconitase proteins
Tang, Y., Guest, J. R., Artymiuk, P. J., Read, R. C., & Green, J. D. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2003.03954.x · Cited by 53
Diet shapes the ability of human intestinal microbiota to degrade phytate - in vitro studies
Markiewicz, L. H., Honke, J., Haros, C. M., Swiatecka, D., & Wróblewska, B. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12204 · Cited by 51
Iron-ascorbate alters the efficiency of Caco-2 cells to assemble and secrete lipoproteins
Courtois, F., Suc, I., Garofalo, C., Ledoux, M., Seidman, E. G., & Levy, E. H. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.1.g12 · Cited by 51
Herold, S., Paton, J. C., Srimanote, P., & Paton, A. W. (2009) · Microbiology · doi:10.1099/mic.0.029454-0 · Cited by 51
Freitas, K. D. C., Amâncio, O. M. S., & de Morais, M. B. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006301 · Cited by 49
Reddy, B. S., Pleasants, J. R., & Wostmann, B. S. (1972) · Journal of Nutrition · doi:10.1093/jn/102.1.101 · Cited by 48
Intraluminal transport of iron from stomach to small-intestinal mucosa
Jacobs, A., & Miles, P. M. (1969) · BMJ · doi:10.1136/bmj.4.5686.778 · Cited by 46
Butcher, J., & Stintzi, A. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079475 · Cited by 45
Romanowski, K. S. S., Zaborin, A., Fernandez, H. T., Poroyko, V. A., Valuckaite, V., Gerdes, S., Liu, D. C., Zaborina, O. Y., & Alverdy, J. C. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-212 · Cited by 43
Ferruzza, S., Scarino, M. L., Gambling, L., Natella, F., & Sambuy, Y. (2003) · PubMed · Cited by 42
Switching aconitase B between catalytic and regulatory modes involves iron‐dependent dimer formation
Tang, Y., Guest, J. R., Artymiuk, P. J., & Green, J. D. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04610.x · Cited by 40
Siderocalin Outwits the Coordination Chemistry of Vibriobactin, a Siderophore of Vibrio cholerae
Allred, B. E., Correnti, C., Clifton, M. C., Strong, R. K., & Raymond, K. N. (2013) · ACS Chemical Biology · doi:10.1021/cb4002552 · Cited by 39
Foster, S. L., Richardson, S. H., & Failla, M. L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1452 · Cited by 39
Utilization of exogenous siderophores by Campylobacter species
Baig, B. H., Wachsmuth, I. K., & Morris, G. K. (1986) · Journal of Clinical Microbiology · doi:10.1128/jcm.23.3.431-433.1986 · Cited by 38
Research works printed but not linked: 1
- Kortman GAM Maathuis AJH Roeselers G et al. (2014) Dietary iron shifts gut microbial metabolism towards a more toxic profile. Abstract Rowett-INRA Gut Microbiology conference.
Cited by
Sorted by citations
Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 563
Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
Dubinkina, V. B., Tyakht, A., Odintsova, V. Y., Yarygin, K. S., Kovarsky, B. A., Pavlenko, A. V., Ischenko, D. S., Popenko, A., Alexeev, D. G., Taraskina, A. Y., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0359-2 · Cited by 472
Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?
Knežević, J., Starchl, C., Tmava‐Berisha, A., & Amrein, K. (2020) · Nutrients · doi:10.3390/nu12061769 · Cited by 368
Paganini, D., & Zimmermann, M. B. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156067 · Cited by 262
Metadata
- Authors
- Kortman, G. A. M., Raffatellu, M., Swinkels, D. W., & Tjalsma, H.
- Affiliations
- Radboud University Medical Center (NL)
- University of California, Irvine (US)
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-11
- Volume
- 38
- Issue
- 6
- Pages
- 1202-1234
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2110302416
- Semantic Scholar
- 12883cc5aa8bb7572bc2d56537b17a16503466ea
- Cited by
- 291
- References
- 227
- Citations by year
- 2026: 26 · 2025: 24 · 2024: 18 · 2023: 38 · 2022: 34 · 2021: 21 · 2020: 21 · 2019: 28 · 2018: 22 · 2017: 34 · 2016: 12 · 2015: 13
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Reviews (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (U54AI065359)
- Dutch Digestive Diseases Foundation (WO 10-53)
- Public Health Service Grants (AI083663, AI105374)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- iron deficiency, oral iron supplementation, gut microbiota, host-microbiota interactions, Salmonella typhimurium, iron limitation, iron acquisition, bacterial virulence, intestinal inflammation, intestinal immunity, colonic lumen, bacterial metabolism, bacterial community composition
- MeSH terms
- Bacteria, Humans, Intestines, Iron, Oxidation-Reduction, Stress, Physiological, Iron, Dietary, Biodiversity, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
