The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Senescence-associated lncRNAs: senescence-associated long noncoding RNAs
Open accessAbstract
Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally. Here, we sought to identify lncRNAs differentially expressed during replicative senescence. We compared lncRNAs expressed in proliferating, early-passage, 'young' human diploid WI-38 fibroblasts [population doubling (PDL) 20] with those expressed in senescent, late-passage, 'old' fibroblasts (PDL 52) by RNA sequencing (RNA-Seq). Numerous transcripts in all lncRNA groups (antisense lncRNAs, pseudogene-encoded lncRNAs, previously described lncRNAs and novel lncRNAs) were validated using reverse transcription (RT) and real-time, quantitative (q)PCR. Among the novel senescence-associated lncRNAs (SAL-RNAs) showing lower abundance in senescent cells, SAL-RNA1 (XLOC_023166) was found to delay senescence, because reducing SAL-RNA1 levels enhanced the appearance of phenotypic traits of senescence, including an enlarged morphology, positive β-galactosidase activity, and heightened p53 levels. Our results reveal that the expression of known and novel lncRNAs changes with senescence and suggests that SAL-RNAs play direct regulatory roles in this important cellular process.
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Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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“Since senescent cells accumulate in tissues as the organism ages, their metabolic behavior and their signature gene expression profile have been linked to a number of age-related physiologic and pathologic changes (Tyner et al., 2002; Baker et al., 2011).”
BackgroundRegulation of mRNA Translation and Stability by microRNAs
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“…the stability of target mRNAs [e.g., 1/2-sbsRNAs, lincRNA-p21 (Gong & Maquat, 2011; Yoon et al., 2012)], while lncRNAs that do not basepair can affect precursor mRNA splicing and translation by acting as cofactors, competitors, or decoys of RBPs or microRNAs [e.g., lincMD1 (Cesana et al., 2011)].”
BackgroundOncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
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“Finally, cellular senescence is characterized by the presence of factors that govern tumor suppression networks, including the p53/p21 and the pRB/p16 tumor suppressor pathways (Kuilman et al., 2010).”
BackgroundInfluentialFour faces of cellular senescence
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“Many senescent cells also display a characteristic senescence-associated secretory phenotype (SASP; Rodier & Campisi, 2011; Tominaga-Yamanaka et al., 2012); among the secreted factors are numerous cytokines and chemokines [e.g., granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin…”
BackgroundImproving RNA-Seq expression estimates by correcting for fragment bias
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Backgroundp16INK4a Translation Suppressed by miR-24
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“The second comprises miRNAs, a large group of small (~22 nt), noncoding RNAs that are differentially expressed during senescence and control numerous senescence traits in cultured cells as well as in animal models (Lal et al., 2008; Maes et al., 2009; Marasa et al., 2010; Bonifacio & Jarstfer, 2010; Wang et al., 2011;…”
BackgroundSelf-citation
Cited by
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
History, Discovery, and Classification of lncRNAs
Jarroux, J., Morillon, A., & Pinskaya, M. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-5203-3_1 · Cited by 865
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 295
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
Bhan, A., & Mandal, S. S. (2014) · ChemMedChem · doi:10.1002/cmdc.201300534 · Cited by 279
Metadata
- Authors
- Abdelmohsen, K., Panda, A., Kang, M.-J., Xu, J., Selimyan, R., Yoon, J.-H., Martindale, J. L., De, S., Wood, W. H., Becker, K. G., & Gorospe, M.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2013-07-14
- Volume
- 12
- Issue
- 5
- Pages
- 890-900
- ISSN
- 1474-9718 (ISSN-L)
- OpenAlex
- W2005258788
- Cited by
- 208
- References
- 14
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Abdelmohsen, K., Panda, A., Kang, M.-J., Xu, J., Selimyan, R., Yoon, J.-H., Martindale, J. L., De, S., Wood, W. H., Becker, K. G., & Gorospe, M. (2013). Senescence-associated lncRNAs: senescence-associated long noncoding RNAs. Aging Cell. https://doi.org/10.1111/acel.12115
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