Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus
Open accessAbstract
Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age‐dependent decline of hippocampal neurogenesis are yet not fully understood. The progressive loss of neural stem cells (NSCs) is a main factor, but the true neurogenic output depends initially on the actual number of activated NSCs in each given time point. Because the fraction of activated NSCs remains constant relative to the total population, the real number of activated NSCs declines in parallel to the total NSC pool. We investigated aging‐associated changes in NSCs and found that there are at least two distinct populations of NSCs. An alpha type, which maintains the classic type‐1 radial morphology and accounts for most of the overall NSC mitotic activity; and an omega type characterized by increased reactive‐like morphological complexity and much lower probability of division even under a pro‐activation challenge. Finally, our results suggest that alpha‐type NSCs are able to transform into omega‐type cells overtime and that this phenotypic and functional change might be facilitated by the chronic inflammation associated with aging.
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IFNα has an overall negative impact on the brain, and chronic inflammation and IFNα convert αNSCs into ΩNSCs, which are more quiescent.
“Although IFNγ can also have positive effects, IFNα has an overall negative impact on the brain137. Chronic inflammation and IFNα convert αNSCs into ΩNSCs, which are more quiescent138.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [138]
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Gasperini, C., Tuntevski, K., Pelizzoli, R., Van, A. L., Mangoni, D., Cossu, R. M., Pascarella, G., Bianchini, P., Bielefeld, P., Scarpato, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.15.297739 · Cited by 7 · see citing works
Pastor-Alonso, O., Zahra, A. S., Kaske, B., García‐Moreno, F., Tetzlaff, F., Bockelmann, E., Grunwald, V., Martín‐Suárez, S., Riecken, K., Witte, O. W., et al. (2023) · The EMBO Journal · doi:10.1038/s44318-023-00011-2 · Cited by 5 · see citing works
Self-citationRuiz-Clavijo, L., & Martín‐Suárez, S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1186256 · Cited by 5 · see citing works
Self-citationMouse Models for Studying Hippocampal Adult Neural Stem Cell Biology
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Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability
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Tertiary damage: Hippocampal and brain changes after spinal cord injury
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Isolation of Adult Hippocampal Neural Stem Cells
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Self-citationSex‐Specific Neurogenic and Cognitive Responses in a Murine Model of Accelerated Aging
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Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate GyrusPreprint
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Comparison of the Neural Stem Cell Heterogeneity Model for Radiation Research
Glebov, A. A., Kolesnikova, E. A., & Bugay, A. N. (2026) · Physics of Particles and Nuclei Letters · doi:10.1134/s1547477126700834
- Authors
- Martín‐Suárez, S., Valero, J., Muro‐García, T., & Encinas, J. M.
- Affiliations
- Achucarro Basque Center for Neuroscience (ES)
- Ikerbasque (ES)
- Corresponding author
- Encinas, Juan Manuel
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2019-04-15
- Volume
- 18
- Issue
- 4
- Pages
- e12958-e12958
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC6612636
- OpenAlex
- W2940381893
- Cited by
- 58
- References
- 46
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 2 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Hispana (publishedVersion, other-oa)
- Hispana (submittedVersion, cc-by)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Gredos (University of Salamanca) (submittedVersion, other-oa)
- Funders
- Eusko Jaurlaritza (PI-2016-0011)
- Ministerio de Economía y Competitividad (BFU2015-66689, RyC-2012-11137, SAF-2015-70866)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neural stem cells, hippocampus, adult neurogenesis, aging, stem cell heterogeneity, stem cell activation, mitotic activity, chronic inflammation, stem cell differentiation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Differentiation, Inflammation, Mice, Transgenic, Minocycline, Mitosis, Phenotype, Cellular Senescence, Dentate Gyrus, Mice, Neurogenesis, Neural Stem Cells
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