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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis

Fan, Shou‐Zen, Lin, Cheng‐Sheng, Wei, Yu‐Wen, Yeh, Sheng‐Rong, Tsai, Yi‐Hsuan, Lee, Andrew Chengyu, Lin, Wei‐Sheng, Wang, Pei‐Yu·2021·Aging Cell
DOI 10.1111/acel.13510PMC PMC8672782
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Abstract

Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood. Here, we report that dietary supplementation with citrate significantly reduces energy status and extends lifespan in Drosophila melanogaster. Our genetic studies in fruit flies implicate a molecular mechanism associated with AMP‐activated protein kinase (AMPK), target of rapamycin (TOR), and ketogenesis. Mice fed a high‐fat diet that supplemented with citrate or the ketone body β‐hydroxybutyrate (βOHB) also display improved metabolic health and memory. These results suggest that dietary citrate supplementation may prove to be a useful intervention in the future treatment of age‐related dysfunction.

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Metadata

Authors
Fan, S., Lin, C., Wei, Y., Yeh, S., Tsai, Y., Lee, A. C., Lin, W., & Wang, P.
Affiliations
  • Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan
  • Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
  • Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan
ORCID
Wang, Pei‐Yu
Venue
Aging Cell
Publisher
Wiley
Published
2021-10-31
Volume
20
Issue
12
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1111/acel.13510
PMC
PMC8672782
Cited by
63
References
9
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Ministry of Science and Technology, Taiwan (107‐2410‐H‐002‐118, 108‐2314‐B‐002‐092, 108‐2410‐H‐002‐102, 109‐2311‐B‐002‐007)

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