Risk‐preferring rats make worse decisions and show increased incubation of craving after cocaine self‐administration

Ferland, Jacqueline‐Marie N.; Winstanley, Catharine A.

doi:10.1111/adb.12388

Cited by 72Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

Risk‐preferring rats make worse decisions and show increased incubation of craving after cocaine self‐administration

Ferland, Jacqueline‐Marie N., Winstanley, Catharine A.·2017·Addiction Biology

DOI 10.1111/adb.12388

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Abstract

Maladaptive decision‐making may play an integral role in the development and maintenance of an addiction. Substance‐dependent individuals make riskier choices on the Iowa Gambling Task, and these deficits persist during withdrawal and are predictive of relapse. However, it is unclear from clinical studies whether this cognitive impairment is a cause or consequence of drug use. We trained male Long‐Evans rats on the rat Gambling Task, a rodent analogue of the Iowa Gambling Task, to determine how choice preference influenced, and was influenced by, cocaine self‐administration, withdrawal and incubation of craving. Rats that exhibited a preference for the risky, disadvantageous options at baseline were uniquely and adversely affected by cocaine self‐administration. Risky choice was exacerbated in these rats when decision‐making was assessed during the same diurnal period as cocaine self‐administration, whereas the choice pattern of optimal decision‐makers was unaffected. This decision‐making deficit was maintained during 30 days of withdrawal and correlated with greater cue‐induced incubation of craving. Risk‐preferring rats also made more drug‐seeking responses during cocaine self‐administration. These data demonstrate that poor decision‐making prior to contact with addictive drugs is associated with a pro‐addictive behavioural phenotype, characterized by further increased risky choice and heightened responding for drug both during cocaine self‐administration and withdrawal. Such findings indicate that the elevated risky decision‐making observed in substance‐dependent populations is not merely circumstantial, but makes an important contribution to addiction vulnerability and severity that can now be effectively modelled in laboratory rats.

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Risk-preferring animals in the rodent gambling task make more drug-seeking responses and show greater cue-induced incubation of craving after cocaine self-administration.
“While the majority of animals learn to choose the safe and advantageous options, a small proportion tend to be more risk-preferring, and these risk-preferring animals make more drug-seeking responses and show greater cue-induced incubation of craving after cocaine self-administration (Ferland & Winstanley, 2016).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Ferland & Winstanley, 2016

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Authors: Ferland, J. N., & Winstanley, C. A.
Affiliations: University of British Columbia (CA)
Corresponding author: Ferland, Jacqueline‐Marie N.
ORCID: Ferland, Jacqueline‐Marie N.
Winstanley, Catharine A.
Venue: Addiction Biology
Publisher: Wiley
Published: 2016-03-22
Volume: 22
Issue: 4
Pages: 991-1001
ISSN: 1355-6215 (ISSN-L)
1369-1600
DOI: 10.1111/adb.12388
OpenAlex: W2309365610
Cited by: 72
References: 54
Citations by year: 2026: 5 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 3
FWCI: 6.17
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Addiction Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Michael Smith Health Research BC
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: risk preferences, risky decision making, cocaine self-administration, cocaine withdrawal, cue-induced craving, drug-seeking behavior, addiction vulnerability, relapse
MeSH terms: Animals, Behavior, Animal, Cocaine, Decision Making, Disease Models, Animal, Male, Risk, Self Administration, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats, Long-Evans, Rats, Craving

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Risk‐preferring rats make worse decisions and show increased incubation of craving after cocaine self‐administration

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