Cited by 499Dermatology and Skin DiseasesContact Dermatitis and AllergiesAsthma and respiratory diseases

New insights into the epidemiology of childhood atopic dermatitis

Open access
Flohr, C., Mann, J.·2014·Allergy

Abstract

There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis ( AD ). Trend data on the burden of AD suggest that the picture in the developing world may soon resemble that of wealthier nations, where AD affects over 20% of children. This, combined with significant variations in prevalence within countries, emphasizes the importance of environmental factors. Many hypotheses have been explored, from the modulation of immune priming by hygiene, gut microbiota diversity, and exposure to endotoxins through farm animals to the effects of pollution, climate, and diet. The discovery of the filaggrin skin barrier gene and its importance in AD development and severity has brought the focus on gene–environment interactions and the identification of environmental factors that impact on skin barrier function. This article reviews our current understanding of the epidemiology of AD , with an emphasis on the findings reported in the international literature over the last 5 years.

Integrity signals

Registry

Crossref · 10.1111/all.12270

Cites

179 of 179 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Flohr, C., & Mann, J.
Affiliations
  • Guy's Hospital (GB)
  • Medway NHS Foundation Trust (GB)
Corresponding author
Flohr, C.
Venue
Allergy
Publisher
Wiley
Published
2013-11-21
Volume
69
Issue
1
Pages
3-16
ISSN
  • 0105-4538 (ISSN-L)
  • 1398-9995
OpenAlex
W2018916159
Cited by
499
References
179
Citations by year
2026: 14 · 2025: 23 · 2024: 32 · 2023: 31 · 2022: 29 · 2021: 54 · 2020: 52 · 2019: 48 · 2018: 49 · 2017: 46 · 2016: 53 · 2015: 41 · 2014: 25 · 2013: 1 · 2012: 1
FWCI
6.62
Type
journal article
Language
en
Open access
Locations
  • Allergy (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
pediatric atopic dermatitis, environmental risk factors, hygiene hypothesis, gut microbiota, endotoxin exposure, farm animal exposure, pollution, climate, diet, filaggrin, skin barrier function, gene-environment interaction, immune priming
MeSH terms
Filaggrin Proteins, Child, Dermatitis, Atopic, Environment, Humans, Risk Factors, Global Health, Prevalence, Gene-Environment Interaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review