Collaborative Approach in the Development of High‐Performance Brain–Computer Interfaces for a Neuroprosthetic Arm: Translation from Animal Models to Human Control
Open accessAbstract
Our research group recently demonstrated that a person with tetraplegia could use a brain–computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able‐bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short‐term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real‐world clinical situations.
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EEG-based BCIs aimed at restorative arm and hand interventions are among the least effective BCI systems.
“electroencephalography (EEG) based BCIs targeting such restorative interventions are some of the least effective (12, 13).”
From Noninvasive neuroimaging enhances continuous neural tracking for robotic device control (2019) · cites this paper as [12]
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- Authors
- Collinger, J. L., Kryger, M. A., Barbara, R., Betler, T., Bowsher, K., Brown, E. H. P., Clanton, S. T., Degenhart, A. D., Foldes, S. T., Gaunt, R. A., Gyulai, F. E., Harchick, E. A., Harrington, D., Helder, J. B., Hemmes, T., Johannes, M. S., Katyal, K. D., Ling, G. S. F., McMorland, A. J. C., Palko, K., Para, M. P., Scheuermann, J., Schwartz, A. B., Skidmore, E. R., Solzbacher, F., Srikameswaran, A. V., Swanson, D. P., Swetz, S., Tyler‐Kabara, E. C., Velliste, M., Wang, W., Weber, D. J., Wodlinger, B., & Boninger, M. L.
- Affiliations
- Veterans Health Administration (US)
- Department of Physical Medicine & Rehabilitation
- University of Pittsburgh (US)
- United States Food and Drug Administration (US)
- Johns Hopkins University Applied Physics Laboratory (US)
- Defense Advanced Research Projects Agency (US)
- Systems Neuroscience Institute
- University of Utah (US)
- Research Conduct and Compliance Office
- McGowan Institute for Regenerative Medicine (US)
- Corresponding author
- Boninger, Michael L.
- ORCID
- Venue
- Clinical and Translational Science
- Publisher
- Wiley
- Published
- 2013-08-27
- Volume
- 7
- Issue
- 1
- Pages
- 52-59
- ISSN
- 1752-8054 (ISSN-L)
- 1752-8062
- PMC
- PMC3929226
- OpenAlex
- W1796170220
- Cited by
- 68
- References
- 65
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- public-domain
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- Locations
- Clinical and Translational Science (publishedVersion)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000005, KL2TR000146)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- brain-computer interface, tetraplegia, robotic arm control, animal-to-human translation, epilepsy monitoring unit, multidisciplinary collaboration, clinical trial design
- MeSH terms
- Adult, Animals, Artificial Limbs, Cooperative Behavior, Electroencephalography, Humans, Male, Primates, Prosthesis Design, Quadriplegia, Robotics, Software, Spinal Cord Injuries, User-Computer Interface, Models, Animal, Translational Research, Biomedical, Brain-Computer Interfaces
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