CoChat
Sign Up
Cited by 40

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Effectiveness of low-carbohydrate diets for long-term weight loss in obese individuals: a meta-analysis of randomized controlled trials

Silverii, Giovanni Antonio, Cosentino, Claudia, Santagiuliana, Federica, Rotella, Francesco, Benvenuti, Federica, Mannucci, Edoardo, Cresci, Barbara·2022·Diabetes, Obesity and Metabolism
DOI 10.1111/dom.14709PMC PMC9546386
Open this paper in CoChat — free account

Abstract

Aim: To assess whether low‐carbohydrate (LC) diets are associated with differences in weight loss and well‐being in people with obesity, and their cardiovascular and renal safety. Materials and Methods: A meta‐analysis of randomized controlled trials longer than 3 months, retrieved through an extensive search on MedLine and Embase databases, comparing weight loss with LC and control diets in people with body mass index (BMI) greater than 30 kg/m 2 , was conducted. Results: We retrieved 25 trials. Compared with controls, LC diets were associated with significant reduction of body weight at 3‐4 (MD −2.59 [−3.93, −1.25] kg) and 6‐8 months (MD −2.64 [−4.32, −0.95]), but no difference at 10‐14 and 18‐30 months, and significantly greater BMI reduction at 3‐4 months (−1.66 [−2.70, −0.61] kg/m 2 ), but not at other time points. Because only four trials reported data on renal function and psychological variables, renal safety and impact on well‐being could not be assessed. Differences in fasting plasma glucose at any time point were not statistically significant. No significant differences in total or LDL cholesterol or blood pressure were found in the long term, whereas a long‐term reduction of triglycerides (23.26 [−45.53, −0.98] mg/dl at 18‐30 months), and increase of HDL cholesterol (MD 4.94 [0.30, 9.57] mg/dl at 18‐30 months), were observed. Conclusion: LC diets are associated with greater short‐term weight loss than non‐carbohydrate–restricted diets and a longer term favourable effect on cardiovascular risk factors. Further evidence on long‐term efficacy and renal safety is needed before LC diets can be recommended as the preferred diets in obese people.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/dom.14709

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several systematic reviews and meta-analyses over the past decade have unanimously shown that low-carbohydrate diets produce superior weight loss to low-fat diets, with mean differences ranging 1.01-2.64 kg.

    “Several systematic reviews and meta-analyses over the past decade have examined the effects of LCDs, unanimously showing superior weight loss to LFDs [136,138–145], with mean differences ranging 1.01–2.64 kg.”

    From International Society of Sports Nutrition position stand: diets for body weight reduction (2026) · cites this paper as [143]

    The Results (Weight loss; page not provided) report greater weight loss with low-carbohydrate diets at 3–4 and 6–8 months, including a mean difference of 2.64 kg. But the comparison was with non-carbohydrate-restricted diets, not specifically low-fat diets, and the advantage was not significant at later time points. The copy does not establish unanimous findings across reviews or the lower end of the stated 1.01–2.64 kg range. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • A systematic review and meta-analysis of 25 RCTs by Silverii et al. reported that, compared to control diets, low-carbohydrate diets statistically reduced body weight at 3-4 and 6-8 months, but the difference was no longer statistically significant at 10-14 and 18-30 months.

    “In a systematic review and meta-analysis of 25 RCTs, Silverii et al. [143] reported that, compared to control diets, LCDs statistically reduced body weight at 3–4 and 6–8 months, but the difference was no longer statistically significant at 10–14 and 18–30 months.”

    From International Society of Sports Nutrition position stand: diets for body weight reduction (2026) · cites this paper as [143]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 54

  1. 10.1001/jamanetworkopen.2018.3788 · DOI
  2. 10.1016/S1470‐2045(14)71123‐4 · DOI
  3. 10.1016/j.canep.2016.02.010 · DOI
  4. 10.1016/S0140‐6736(08)60269‐X · DOI · Paper page
  5. 10.1159/000362191 · DOI
  6. 10.1038/s41598‐018‐33563‐z · DOI
  7. 10.1136/bmj.l5584 · DOI · Paper page
  8. 10.1159/000496183 · DOI · Paper page
  9. Amerio ML, 2017, Standard Italiani per la Cura dell'Obesità SIO‐ADI 2016‐2017, SIO (Società Ital Dell'Obesità), 1, 1
  10. 10.1016/j.jand.2015.10.031 · DOI
  11. 10.1503/cmaj.191707 · DOI · Paper page
  12. 10.1016/j.jacc.2013.11.004 · DOI · Paper page
  13. 10.1016/S0939‐4753(04)80052‐8 · DOI
  14. 10.1056/NEJMoa025039 · DOI · Paper page
  15. 10.1001/jama.297.19.2092 · DOI · Paper page
  16. 10.1016/j.eclnm.2011.04.003 · DOI
  17. 10.3390/molecules24132499 · DOI
  18. 10.1007/s13679‐021‐00451‐z · DOI · Paper page
  19. 10.1053/j.jrn.2017.11.008 · DOI
  20. 10.2337/dc21‐1211 · DOI
  21. 10.1093/nutrit/nuaa044 · DOI
  22. 10.1159/000515381 · DOI · Paper page
  23. 10.1093/eurheartj/ehaa575 · DOI · Paper page
  24. 10.1017/S0007114513000548 · DOI · Paper page
  25. 10.1001/jama.2014.10397 · DOI · Paper page
  26. 10.1111/obr.12405 · DOI · Paper page
  27. Italian Society of human nutrition, 2014, LARN: Nutrients and Energy Intake Standard Levels for the Italian Population: 4th revision
  28. 10.2903/j.efsa.2015.3957 · DOI
  29. 10.1016/j.jclinepi.2010.09.011 · DOI · Paper page
  30. 10.1097/OGX.0b013e31821342ba · DOI
  31. 10.7326/M14‐0180 · DOI · Paper page
  32. 10.1002/oby.20320 · DOI
  33. 10.7326/M14‐2358.Effect · DOI
  34. 10.3390/nu13041187 · DOI
  35. 10.1007/s11745‐015‐4113‐x · DOI
  36. 10.1016/j.cmet.2017.04.011 · DOI
  37. 10.1007/s00592‐020‐01568‐8 · DOI
  38. 10.1016/j.clnu.2016.11.007 · DOI
  39. Patsalos O, 2021, Diet, obesity, and depression: a systematic review, J Pers Med, 1
  40. 10.1177/1359105307071741 · DOI · Paper page
  41. 10.1038/ijo.2011.2 · DOI
  42. 10.3945/cdn.117.000703 · DOI
  43. 10.2337/dc08‐0687 · DOI · Paper page
  44. 10.1038/oby.2005.79 · DOI · Paper page
  45. 10.1111/j.1464‐5491.2005.01760.x · DOI
  46. 10.1016/j.jdiacomp.2007.12.006 · DOI
  47. 10.1007/s40618‐015‐0304‐9 · DOI
  48. 10.1186/1475‐2891‐9‐59 · DOI · Paper page
  49. 10.2337/dc12‐1912 · DOI
  50. 10.1111/dom.13915 · DOI
  51. 10.1093/ajcn/61.3.486 · DOI · Paper page
  52. 10.1136/bmjdrc‐2016‐000258 · DOI · Paper page
  53. 10.1111/jhn.12118 · DOI
  54. 10.7326/0003-4819-140-10-200405180-00006 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Silverii, G. A., Cosentino, C., Santagiuliana, F., Rotella, F., Benvenuti, F., Mannucci, E., & Cresci, B.
Affiliations
  • Biomedical Sciences Department Florence University Florence
  • Diabetology Unit Pistoia San Jacopo Hospital Pistoia Italy
  • Diabetology Careggi Hospital Florence Italy
  • Psychiatry Careggi Hospital Florence Italy
ORCID
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2022-05-26
Volume
24
Issue
8
Pages
1458-1468
ISSN
  • 1462-8902
  • 1463-1326
DOI
10.1111/dom.14709
PMC
PMC9546386
Cited by
40
References
17
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review