Cited by 26Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeural and Behavioral Psychology Studies

The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex

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Gil‐Miravet, Isis, Guarque‐Chabrera, Julian, Carbo‐Gas, Maria, Olucha‐Bordonau, Francisco, Miquel, Marta·2019·European Journal of Neuroscience

Abstract

Drug‐induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug‐related memory depends on persistent changes in dopamine‐glutamate interactions in the medial prefrontal cortex (mPFC), basolateral amygdala, nucleus accumbens core and hippocampus. Recent evidence from our laboratory indicated that the cerebellum is also a relevant node for drug‐cue associations. In the present study, we tested the role that specific regions of the cerebellum and mPFC play in the acquisition of cocaine‐induced preference conditioning. Quinolinic acid was used to manage a permanent deactivation of lobule VIII in the vermis prior to conditioning. Additionally, lidocaine was infused into the prelimbic and infralimbic (IL) cortices for reversible deactivation before every training session. The present findings show, for the first time, that the cerebellum and mPFC might act together in order to acquire drug‐cue Pavlovian associations. Either a dorsal lesion in lobule VIII or an IL deactivation encouraged cocaine‐induced preference conditioning. Moreover, simultaneous IL‐cerebellar deactivation prevented the effect of either of the separate deactivations. Therefore, similar to the IL cortex, neural activity in the cerebellum may be crucial for ensuring inhibitory control of the expression of cocaine‐related memories.

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Crossref · 10.1111/ejn.14187

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  • Ethanol, nicotine, cocaine, and heroin alter the intensity or number of PNNs in various brain regions.

    “Several classes of drugs, including ethanol, nicotine, cocaine, and heroin, alter the intensity or number of PNNs in various brain regions, including the mPFC [154, 155], anterior cingulate cortex [131], orbitofrontal cortex [156], barrel cortex [157], insula [158], hypothalamus [159, 160], ventral tegmental area [156], and cerebellum [161–164].”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [155]

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Authors
Gil‐Miravet, I., Guarque‐Chabrera, J., Carbo‐Gas, M., Olucha‐Bordonau, F., & Miquel, M.
Affiliations
  • Universitat Jaume I (ES)
  • Área de Psicobiología Universitat Jaume I Castellón de la Plana Spain
  • UP Medicina Universitat Jaume I Castellón de la Plana Spain
Corresponding author
Miquel, Marta
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2018-10-24
Volume
50
Issue
3
Pages
2613-2622
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2895536619
Cited by
26
References
71
Citations by year
2025: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Repositori UJI (Universitat Jaume I) (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, public-domain)
Funders
  • Universitat Jaume I (PREDOC2014/11, UJI (14I307.01/1))
  • Ministerio de Economía y Competitividad (PSI2015‐68600‐P)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cerebellum, medial prefrontal cortex, classical conditioning, infralimbic cortex, prelimbic cortex, quinolinic acid lesion, lidocaine inactivation, drug addiction, dopamine-glutamate interaction
MeSH terms
Animals, Association Learning, Cerebellum, Cocaine, Conditioning, Classical, Cues, Injections, Intraventricular, Male, Memory, Neural Pathways, Rats, Sprague-Dawley, Prefrontal Cortex, Dopamine Uptake Inhibitors, Rats

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