The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
THE LOCI OF REPEATED EVOLUTION: A CATALOG OF GENETIC HOTSPOTS OF PHENOTYPIC VARIATION: PERSPECTIVE
Abstract
What is the nature of the genetic changes underlying phenotypic evolution? We have catalogued 1008 alleles described in the literature that cause phenotypic differences among animals, plants, and yeasts. Surprisingly, evolution of similar traits in distinct lineages often involves mutations in the same gene ("gene reuse"). This compilation yields three important qualitative implications about repeated evolution. First, the apparent evolution of similar traits by gene reuse can be traced back to two alternatives, either several independent causative mutations or a single original mutational event followed by sorting processes. Second, hotspots of evolution-defined as the repeated occurrence of de novo mutations at orthologous loci and causing similar phenotypic variation-are omnipresent in the literature with more than 100 examples covering various levels of analysis, including numerous gain-of-function events. Finally, several alleles of large effect have been shown to result from the aggregation of multiple small-effect mutations at the same hotspot locus, thus reconciling micromutationist theories of adaptation with the empirical observation of large-effect variants. Although data heterogeneity and experimental biases prevented us from extracting quantitative trends, our synthesis highlights the existence of genetic paths of least resistance leading to viable evolutionary change.
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Cites
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The probability of parallel genetic evolution from standing genetic variation
MacPherson, A., & Nuismer, S. L. (2017) · Journal of Evolutionary Biology · doi:10.1111/jeb.13006 · Cited by 79
Fukushima, K., & Pollock, D. D. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01932-7 · Cited by 55
Podobnik, M., Frohnhöfer, H. G., Dooley, C. M., Eskova, A., Nüsslein-Volhard, C., & Irion, U. (2020) · Nature Communications · doi:10.1038/s41467-020-20021-6 · Cited by 26
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Metadata
- Authors
- Martin, A., & Orgogozo, V.
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-03
- Volume
- 67
- Issue
- 5
- Pages
- n/a-n/a
- ISSN
- 0014-3820 (ISSN-L)
- OpenAlex
- W2115669899
- Cited by
- 497
- References
- 13
- FWCI
- 29.54
- Type
- journal article
- Language
- en
- Open access
- closed
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