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Convergent regulatory evolution and loss of flight in paleognathous birds

Sackton, Timothy B., Grayson, Phil, Cloutier, Alison, Hu, Zhirui, Liu, Jun S., Wheeler, Nicole E., Gardner, Paul P., Clarke, Julia A., Baker, Allan J., Clamp, Michele, Edwards, Scott V.·2019·Science
DOI 10.1126/science.aat7244
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Abstract

All roads lead to regulation: Species from widely divergent taxa can experience similar changes in traits. What underlying genetic drivers cause these parallel changes remains an open question. Sackton et al. looked across groups of birds that have repeatedly lost flight, the ratites and tinamous, and found that there is convergence in the regulatory regions associated with genes related to flight, but not within the protein coding regions. Changes within these regulatory regions influenced limb development and may represent quick paths toward convergent change across taxa. Science , this issue p. 74

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  • Replicated loss of homologous traits has been the focus of many PhyloG2P studies because it has a high chance of producing replicated genetic changes.

    “Replicated loss of homologous traits has been the focus of many PhyloG2P studies, as it has a high chance of producing replicated genetic changes (Prudent et al. 2016; Sackton et al. 2019).”

    From From Trees to Traits: A Review of Advances in PhyloG2P Methods and Future Directions (2025) · cites this paper as Sackton et al. 2019

  • Relatively few applications of PhyloG2P methods have been followed up by transgenic or knockout experiments to verify the role of genetic elements identified in their analysis.

    “However, relatively few applications of PhyloG2P methods have been followed up by transgenic or knockout experiments to verify the role of genetic elements identified in their analysis (Booker et al. 2016; Sackton et al. 2019; Xu et al. 2021; Okuyama et al. 2025).”

    From From Trees to Traits: A Review of Advances in PhyloG2P Methods and Future Directions (2025) · cites this paper as Sackton et al. 2019

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Metadata

Authors
Sackton, T. B., Grayson, P., Cloutier, A., Hu, Z., Liu, J. S., Wheeler, N. E., Gardner, P. P., Clarke, J. A., Baker, A. J., Clamp, M., & Edwards, S. V.
Affiliations
  • Informatics Group, Harvard University, Cambridge, MA, USA.
  • Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  • Department of Statistics, Harvard University, Cambridge, MA, USA.
  • School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
  • Jackson School of Geosciences, University of Texas, Austin, TX, USA.
  • Department of Natural History, Royal Ontario Museum, Toronto, Ontario, Canada.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-04-05
Volume
364
Issue
6435
Pages
74-78
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aat7244
Cited by
291
References
13
Language
en
Funders
National Science Foundation (DEB-1355343)

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