Moderate‐intensity treadmill running promotes expansion of the satellite cell pool in young and old mice
Open accessAbstract
Satellite cells, the myogenic progenitors located at the myofibre surface, are essential for the repair of adult skeletal muscle. There is ample evidence for an age‐linked decline in the number of satellite cells and performance in limb muscles. Hence, an effective means of activating and expanding the satellite cell pool may enhance muscle maintenance and reduce the impact of age‐associated muscle deterioration (sarcopaenia). Accordingly, in the present study, we explored the beneficial effects of endurance exercise on satellite cells in young and old mice. Animals were subjected to an 8‐week moderate‐intensity treadmill‐running approach that does not inflict apparent muscle damage (0° inclination, 11.5 m·min−1 for 30 min·day−1, 6 days·week−1). Myofibres of extensor digitorum longus muscles were then isolated from exercised and sedentary mice and used for monitoring the number of satellite cells, as well as for harvesting individual satellite cells for clonal growth assays. We specifically focused on satellite cell pools of single myofibres, with the view that daily wear of muscles probably affects individual myofibres rather than causing overall muscle damage. We found an expansion of the satellite cell pool in the exercised groups compared to the sedentary groups, with the same increase (~ 1.6‐fold) in both ages. The results of the present study are in agreement with our findings obtained using rat gastrocnemius, indicating the consistent effect of exercise on satellite cell expansion in limb muscles. The experimental paradigm established in the present study is useful for investigating satellite cell dynamics at the myofibre niche, as well as for broader investigations of the impact of physiologically and pathologically relevant factors on adult myogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Muscle cells can regenerate through satellite mesenchymal progenitor cells, but their numbers fall with age, contributing to reduced muscle function.
“While muscle cells can regenerate through satellite mesenchymal progenitor cells, their numbers decline with age, which contributes to reduced muscle function88,89.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [88]
The Introduction describes satellite cells as myogenic progenitors essential for skeletal-muscle repair and reports an age-associated decline in their numbers. It says this decline *may* contribute to muscle deterioration, rather than establishing that it does; it also calls the cells myogenic, not mesenchymal. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAging-induced myosteatosis promotes lipotoxicity and contributes to inflammation.
“Furthermore, aging-induced myosteatosis promotes lipotoxicity (Lptx) and contributes to inflammation [49, 50].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Endurance exercise is protective for mice with mitochondrial myopathy
Wenz, T., Diaz, F., Hernandez, D., & Moraes, C. T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91571.2008 · Cited by 78 · see citing works
RetractedSATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646 · see citing works
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449 · see citing works
Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A., & Morgan, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.05.010 · Cited by 1,445 · see citing works
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,201 · see citing works
Lepper, C., Partridge, T. A., & Fan, C.-M. (2011) · Development · doi:10.1242/dev.067595 · Cited by 1,105 · see citing works
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A. (2011) · Development · doi:10.1242/dev.067587 · Cited by 939 · see citing works
Muscle satellite cells adopt divergent fates
Zammit, P. S., Golding, J. P., Nagata, Y., Hudon, V., Partridge, T. A., & Beauchamp, J. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312007 · Cited by 924 · see citing works
Self-renewal and expansion of single transplanted muscle stem cells
Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S., & Blau, H. M. (2008) · Nature · doi:10.1038/nature07384 · Cited by 901 · see citing works
Relaix, F., & Zammit, P. S. (2012) · Development · doi:10.1242/dev.069088 · Cited by 888 · see citing works
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · see citing works
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works
Sarcopenia: origins and clinical relevance
Rosenberg, I. H. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.003 · Cited by 786 · see citing works
Sarcopenia: etiology, clinical consequences, intervention, and assessment
Lang, T., Streeper, T., Cawthon, P. M., Baldwin, K., Taaffe, D. R., & Harris, T. B. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1059-y · Cited by 780 · see citing works
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777 · see citing works
AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES
Faulkner, J. A., Larkin, L. M., Claflin, D. R., & Brooks, S. V. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04752.x · Cited by 764 · see citing works
Neural stem and progenitor cells in nestin‐GFP transgenic mice
Mignone, J., Kukekov, V. G., Chiang, A., Steindler, D. A., & Enikolopov, G. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.10964 · Cited by 705 · see citing works
Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners
Christov, C., Chrétien, F. C., Abou-Khalil, R., Bassez, G., Vallet, G., Authier, F., Bassaglia, Y., Shinin, V., Tajbakhsh, S., Chazaud, B., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0693 · Cited by 702 · see citing works
HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells
Tatsumi, R., Anderson, J. E., Nevoret, C. J., Halevy, O., & Allen, R. E. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8803 · Cited by 685 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · Cited by 589 · see citing works
Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle
Shefer, G., de Mark, D. P. V., Richardson, J. B., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.022 · Cited by 506 · see citing works
Self-citationNavarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 464 · see citing works
Yablonka‐Reuveni, Z., & Rivera, A. J. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1226 · Cited by 454 · see citing works
Self-citationMuscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417 · see citing works
Proliferation of muscle satellite cells on intact myofibers in culture
Bischoff, R. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90234-4 · Cited by 403 · see citing works
Age‐related differences in absolute numbers of skeletal muscle satellite cells
Gibson, M. C., & Schultz, E. (1983) · Muscle & Nerve · doi:10.1002/mus.880060807 · Cited by 321 · see citing works
A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging
Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0372 · Cited by 320 · see citing works
Regenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 318 · see citing works
Brack, A. S., Bildsoe, H., & Hughes, S. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02602 · Cited by 308 · see citing works
Tatsumi, R., Hattori, A., Ikeuchi, Y., Anderson, J. E., & Allen, R. E. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0062 · Cited by 279 · see citing works
Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 273 · see citing works
Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269 · see citing works
Age‐associated Changes in the Response of Skeletal Muscle Cells to Exercise and Regenerationa
Grounds, M. D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09894.x · Cited by 264 · see citing works
The biochemistry of aging muscle
Carmeli, E., Coleman, R., & Reznick, A. Z. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00220-0 · Cited by 257 · see citing works
Day, K., Shefer, G., Shearer, A., & Yablonka-Reuveni, Z. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.01.006 · Cited by 254 · see citing works
Self-citationRelative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses
Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works
Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging
Brack, A. S., & Rando, T. A. (2007) · Stem Cell Reviews · doi:10.1007/s12015-007-9000-2 · Cited by 238 · see citing works
Age-related muscle dysfunction
Thompson, L. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.003 · Cited by 226 · see citing works
Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells
Day, K. R., Shefer, G., Richardson, J. B., Enikolopov, G., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.026 · Cited by 222 · see citing works
Self-citationYablonka‐Reuveni, Z., Seger, R., & Rivera, A. J. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700104 · Cited by 215 · see citing works
Self-citationKästner, S., Elias, M. C., Rivera, A. J., & Yablonka‐Reuveni, Z. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800805 · Cited by 214 · see citing works
Self-citationShefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 211 · see citing works
Self-citationTreadmill Locomotion in the Intact and Spinal Mouse
Leblond, H., L'esperance, M., Orsal, D., & Rossignol, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11411.2003 · Cited by 201 · see citing works
Lu, Q. L., Morris, G. E., Wilton, S. D., Ly, T., Artem'yeva, O. V., Strong, P. N., & Partridge, T. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.985 · Cited by 196 · see citing works
Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD
Kanisicak, O., Mendez, J. J., Yamamoto, S., Yamamoto, M., & Goldhamer, D. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.554 · Cited by 192 · see citing works
Isolation and Culture of Skeletal Muscle Myofibers as a Means to Analyze Satellite Cells
Keire, P. A., Shearer, A. M., Shefer, G., & Yablonka‐Reuveni, Z. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-128-8_28 · Cited by 187 · see citing works
Self-citationLeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., & Brown, T. A. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp068 · Cited by 180 · see citing works
Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176 · see citing works
The Skeletal Muscle Satellite Cell
Yablonka‐Reuveni, Z. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411426780 · Cited by 164 · see citing works
Self-citationMotor Unit Number Estimates in Masters Runners
Power, G. A., Dalton, B. H., Behm, D. G., Vandervoort, A. A., Doherty, T. J., & Rice, C. L. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181d6f9e9 · Cited by 161 · see citing works
Jackson, J. R., Mula, J., Kirby, T. J., Fry, C. S., Lee, J. D., Ubele, M. F., Campbell, K. S., McCarthy, J. J., Peterson, C. A., & Dupont‐Versteegden, E. E. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00207.2012 · Cited by 158 · see citing works
Systemic and mitochondrial adaptive responses to moderate exercise in rodents
Boveris, A., & Navarro, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.015 · Cited by 151 · see citing works
Wozniak, A. C., & Anderson, J. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21012 · Cited by 145 · see citing works
Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process
Adamo, M. L., & Farrar, R. P. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.05.001 · Cited by 126 · see citing works
Endurance training improves fitness and strength in patients with Becker muscular dystrophy
Sveen, M., Jeppesen, T. D., Hauerslev, S., Køber, L., Krag, T. O. B., & Vissing, J. (2008) · Brain · doi:10.1093/brain/awn189 · Cited by 125 · see citing works
Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 119 · see citing works
Catoire, M., Mensink, M., Boekschoten, M. V., Hangelbroek, R., Müller, M., Schrauwen, P., & Kersten, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051066 · Cited by 116 · see citing works
New records in aerobic power among octogenarian lifelong endurance athletes
Trappe, S. W., Hayes, E., Galpin, A. J., Kaminsky, L. A., Jemioło, B., Fink, W., Trappe, T. A., Jansson, A., Gustafsson, T. P., & Tesch, P. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01107.2012 · Cited by 111 · see citing works
Reduced Satellite Cell Numbers with Spinal Cord Injury and Aging in Humans
Verdijk, L. B., Dirks, M. L., Snijders, T., Prompers, J. J., Beelen, M., Jonkers, R. A. M., Thijssen, D. H. J., Hopman, M. T. E., & van Loon, L. J. C. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182667c2e · Cited by 107 · see citing works
Neal, A., Boldrin, L., & Morgan, J. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037950 · Cited by 99 · see citing works
Starkey, J. D., Yamamoto, M., Yamamoto, S., & Goldhamer, D. J. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.956995 · Cited by 95 · see citing works
Eccentric Exercise Increases Satellite Cell Content in Type II Muscle Fibers
Cermak, N. M., Snijders, T., McKay, B. R., Parise, G., Verdijk, L. B., Tarnopolsky, M. A., Gibala, M. J., & van Loon, L. J. C. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318272cf47 · Cited by 95 · see citing works
Sveen, M., Jeppesen, T. D., Hauerslev, S., Krag, T. O. B., & Vissing, J. (2007) · Neurology · doi:10.1212/01.wnl.0000250358.32199.24 · Cited by 87 · see citing works
Physical activity, exercise, and sarcopenia – future challenges
Freiberger, E., Sieber, C. C., & Pfeifer, K. (2011) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-011-0001-z · Cited by 82 · see citing works
Exercise Training Improves Plantar Flexor Muscle Function in mdx Mice
Baltgalvis, K. A., Call, J. A., COCHRANE, G. D., et al. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31825703f0 · Cited by 72 · see citing works
Isolation and Culture of Skeletal Muscle Myofibers as a Means to Analyze Satellite Cells
Shefer, G., & Yablonka‐Reuveni, Z. (2004) · Humana Press eBooks · doi:10.1385/1-59259-838-2:281 · Cited by 72 · see citing works
Self-citationSnijders, T., Verdijk, L. B., Beelen, M., McKay, B. R., Parise, G., Kadi, F., & van Loon, L. J. C. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.063313 · Cited by 63 · see citing works
Li, P., Akimoto, T., Zhang, M., Williams, R. S., & Yan, Z. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00532.2005 · Cited by 63 · see citing works
PAX7+ satellite cells in young and older adults following resistance exercise
Walker, D. K., Fry, C. S., Drummond, M. J., Dickinson, J. M., Timmerman, K. L., Gundermann, D. M., Jennings, K., Volpi, E., & Rasmussen, B. B. (2011) · Muscle & Nerve · doi:10.1002/mus.23266 · Cited by 57 · see citing works
Pasini, E., Lahaye, S. L. D., Flati, V., Assanelli, D., Corsetti, G., Speca, S., Bernabei, R., Calvani, R., & Marzetti, E. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.10.003 · Cited by 54 · see citing works
Kurosaka, M., Naıto, H., Ogura, Y., Machida, S., & Katamoto, S. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02381.x · Cited by 54 · see citing works
Joya, J. E., Kee, A. J., Nair‐Shalliker, V., Ghoddusi, M., Nguyen, M.-A. T., Luther, P. K., & Hardeman, E. C. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh285 · Cited by 51 · see citing works
Reconstruction of Cell Lineage Trees in Mice
Wasserstrom, A., Adar, R., Shefer, G., Frumkin, D., Itzkovitz, S., Stern, T., Shur, I., Zangi, L., Kaplan, S., Harmelin, A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001939 · Cited by 48 · see citing works
Self-citationEndurance exercise training in myostatin null mice
Savage, K. J., & McPherron, A. C. (2010) · Muscle & Nerve · doi:10.1002/mus.21688 · Cited by 45 · see citing works
Effects of voluntary wheel running on satellite cells in the rat plantaris muscle.
Kurosaka, M., Naıto, H., Ogura, Y., Kojima, A., Goto, K., & Katamoto, S. (2009) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Jeneson, J. A. L., de Snoo, M. W., Verlinden, N. A. T., Joosten, B. J. L. J., Doornenbal, A., Schot, A., & Everts, M. E. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01680.x · Cited by 27 · see citing works
SVEP1 is a Novel Marker of Activated Pre-determined Skeletal Muscle Satellite Cells
Shefer, G., & Benayahu, D. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9106-9 · Cited by 20 · see citing works
Self-citationThe Ins and Outs of Satellite Cell Myogenesis: The Role of the Ruling Growth Factors
Shefer, G., & Yablonka‐Reuveni, Z. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6768-6_6 · Cited by 15 · see citing works
Self-citationLosing stem cells in the aged skeletal muscle niche
Tajbakhsh, S. (2013) · Cell Research · doi:10.1038/cr.2013.3 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2021) · The FASEB Journal · doi:10.1096/fj.202101096r · Cited by 120 · see citing works
The critical role of oxidative stress in sarcopenic obesity
Gonzalez, A., Simon, F., Achiardi, O., Vilos, C., Cabrera, D., & Cabello-Verrugio, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4493817 · Cited by 79 · see citing works
Tidball, J. G., Flores, I., Welc, S. S., Wehling-Henricks, M., & Ochi, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2020.111200 · Cited by 66 · see citing works
- Authors
- Shefer, G., Rauner, G., Stuelsatz, P., Benayahu, D., & Yablonka‐Reuveni, Z.
- Affiliations
- Tel Aviv University (IL)
- University of Washington (US)
- Corresponding author
- Shefer, Gabi
- Benayahu, Dafna
- Yablonka‐Reuveni, Zipora
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2013-04-12
- Volume
- 280
- Issue
- 17
- Pages
- 4063-4073
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- PMC
- PMC3711960
- OpenAlex
- W2048755325
- Cited by
- 72
- References
- 86
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 4
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Israel Science Foundation
- National Institute on Aging (AG-021566, R01AG021566)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- satellite cells, endurance exercise, sarcopenia, aging, skeletal muscle regeneration, myogenesis, extensor digitorum longus
- MeSH terms
- Animals, Cells, Cultured, Exercise Test, Intermediate Filament Proteins, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Promoter Regions, Genetic, Running, Stem Cells, Muscle Fibers, Skeletal, Muscle Development, Satellite Cells, Skeletal Muscle, Cell Proliferation, Green Fluorescent Proteins, Mice, Nestin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
