Cited by 93Telomeres, Telomerase, and SenescenceExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins

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Ludlow, Andrew T., Ludlow, Lindsay W., Roth, Stephen M.·2013·BioMed Research International

Abstract

Aging is associated with a tissue degeneration phenotype marked by a loss of tissue regenerative capacity. Regenerative capacity is dictated by environmental and genetic factors that govern the balance between damage and repair. The age-associated changes in the ability of tissues to replace lost or damaged cells is partly the cause of many age-related diseases such as Alzheimer's disease, cardiovascular disease, type II diabetes, and sarcopenia. A well-established marker of the aging process is the length of the protective cap at the ends of chromosomes, called telomeres. Telomeres shorten with each cell division and with increasing chronological age and short telomeres have been associated with a range of age-related diseases. Several studies have shown that chronic exposure to exercise (i.e., exercise training) is associated with telomere length maintenance; however, recent evidence points out several controversial issues concerning tissue-specific telomere length responses. The goals of the review are to familiarize the reader with the current telomere dogma, review the literature exploring the interactions of exercise with telomere phenotypes, discuss the mechanistic research relating telomere dynamics to exercise stimuli, and finally propose future directions for work related to telomeres and physiological stress.

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Authors
Ludlow, A. T., Ludlow, L. W., & Roth, S. M.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Southern Methodist University (US)
  • University of Maryland, College Park (US)
Corresponding author
Roth, Stephen M.
Venue
BioMed Research International
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-15
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W2154785470
Cited by
93
References
120
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 8 · 2015: 13 · 2014: 4
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Cancer Institute (CA12433404)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
telomere length, exercise training, physiological stress, aging, age-related diseases, telomere dynamics
MeSH terms
Aging, Alzheimer Disease, Cardiovascular Diseases, Humans, Stress, Physiological, Exercise, Telomere, Telomere Homeostasis

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