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Honey bee neurogenomic responses to affiliative and agonistic social interactions
Abstract
Social interactions can be divided into two categories, affiliative and agonistic. How neurogenomic responses reflect these opposing valences is a central question in the biological embedding of experience. To address this question, we exposed honey bees to a queen larva, which evokes nursing, an affiliative alloparenting interaction, and measured the transcriptomic response of the mushroom body brain region at different times after exposure. Hundreds of genes were differentially expressed at distinct time points, revealing a dynamic temporal patterning of the response. Comparing these results to our previously published research on agonistic aggressive interactions, we found both shared and unique transcriptomic responses to each interaction. The commonly responding gene set was enriched for nuclear receptor signaling, the set specific to nursing was enriched for olfaction and neuron differentiation, and the set enriched for aggression was enriched for cytoskeleton, metabolism, and chromosome organization. Whole brain histone profiling after the affiliative interaction revealed few changes in chromatin accessibility, suggesting that the transcriptomic changes derive from already accessible areas of the genome. Although only one stimulus of each type was studied, we suggest that elements of the observed transcriptomic responses reflect molecular encoding of stimulus valence, thus priming individuals for future encounters. This hypothesis is supported by behavioral analyses showing that bees responding to either the affiliative or agonistic stimulus exhibited a higher probability of repeating the same behavior but a lower probability of performing the opposite behavior. These findings add to our understanding of the biological embedding at the molecular level.
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“For species with an extensive repertoire of social behavior, experience and exposure to specific social stimuli can be recorded quantitatively as changes in the gene expression profile (98), much like an odometer records distance.”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [98]
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Cited by
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
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Metadata
- Authors
- Shpigler, H. Y., Saul, M. C., Murdoch, E. E., Corona, F., Cash‐Ahmed, A. C., Seward, C. H., Chandrasekaran, S., Stubbs, L. J., & Robinson, G. E.
- Affiliations
- Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana‐Champaign (UIUC) Urbana Illinois
- Department of Biomedical Engineering University of Michigan Michigan
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2018-09-04
- Volume
- 18
- Issue
- 1
- ISSN
- 1601-1848
- 1601-183X
- Cited by
- 29
- References
- 67
- Language
- en
- Funders
- Simons Foundation (SFLife 291812)
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