Male‐specific alterations in structure of isolation call sequences of mouse pups with 16p11.2 deletion
Open accessAbstract
16p11.2 deletion is one of the most common gene copy variations that increases the susceptibility to autism and other neurodevelopmental disorders. This syndrome leads to developmental delays, including speech impairment and delays in expressive language and communication skills. To study developmental impairment of vocal communication associated with 16p11.2 deletion syndrome, we used the 16p11.2del mouse model and performed an analysis of pup isolation calls (PICs). The earliest PICs at postnatal day 5 from 16p11.2del pups were found altered in a male‐specific fashion relative to wild‐type (WT) pups. Analysis of sequences of ultrasonic vocalizations (USVs) emitted by pups using mutual information between syllables at different positions in the USV spectrograms showed that dependencies exist between syllables in WT mice of both sexes. The order of syllables was not random; syllables were emitted in an ordered fashion. The structure observed in the WT pups was identified and the pattern of syllable sequences was considered typical for the mouse line. However, typical patterns were totally absent in the 16p11.2del male pups, showing on average random syllable sequences, while the 16p11.2del female pups had dependencies similar to the WT pups. Thus, we found that PICs were reduced in number in male 16p11.2 pups and their vocalizations lack the syllable sequence order emitted by WT males and females and 16p11.2 females. Therefore, our study is the first to reveal sex‐specific perinatal communication impairment in a mouse model of 16p11.2 deletion and applies a novel, more granular method of analysing the structure of USVs.
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Male, but not female, 16p11.2+/− mice (Mills) display reduced and altered pup isolation calls, indicating sex-specific communication impairments in perinatal development.
“Male, but not female, 16p11.2+/− mice (Mills) display reduced and altered pup isolation calls, indicating sex-specific communication impairments in perinatal development [74].”
From 16p11.2 Copy Number Variations and Neurodevelopmental Disorders (2020) · cites this paper as [74]
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16p11.2 Copy Number Variations and Neurodevelopmental Disorders
Rein, B., & Yan, Z. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.001 · Cited by 160 · see citing works
- Authors
- Agarwalla, S., Arroyo, N. S., Long, N. E., O'Brien, W. T., Abel, T., & Bandyopadhyay, S.
- Affiliations
- Indian Institute of Technology Kharagpur (IN)
- Weill Cornell Medicine (US)
- University of Pennsylvania (US)
- Department of Pharmacology/ITMAT University of Pennsylvania, School of Medicine Philadelphia Pennsylvania USA
- University of Iowa (US)
- Corresponding author
- Bandyopadhyay, Sharba
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2020-07-06
- Volume
- 19
- Issue
- 7
- Pages
- e12681-e12681
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC7116069
- OpenAlex
- W3036451742
- Cited by
- 26
- References
- 56
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Genes Brain & Behavior (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Indian Institute of Technology Kharagpur (SGIGC‐2015/DMN)
- Ministry of Human Resource Development (Institute Fellowship)
- Simons Foundation Autism Research Initiative (345034)
- The Wellcome Trust DBT India Alliance (IA/I/11/2500270)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
- Keywords
- 16p11.2 deletion syndrome, ultrasonic vocalizations, sex differences, autism spectrum disorder, neurodevelopmental disorders, vocal communication, mouse model, gene copy number variation
- MeSH terms
- Animals, Autistic Disorder, Chromosome Deletion, Chromosomes, Human, Pair 16, Female, Male, Intellectual Disability, Sex Factors, Vocalization, Animal, Chromosome Disorders, Mice
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