The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Intestinal IgA production and its role in host-microbe interaction
Open accessAbstract
Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo-responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non-inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host-microbe interaction.
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“secretory immunoglobulin A (SIgA), which favors commensal bacteria in the gut (Gutzeit et al., 2014),”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Gutzeit et al., 2014
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Gut Microbial Metabolites Fuel Host Antibody Responses
Kim, M., Qie, Y., Park, J., & Kim, C. H. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.001 · Cited by 893
“This activation induces the production of cytokines, retinoic acid (RA) and other B cell-activating molecules by various cell types (Gutzeit et al., 2014; Kim, 2013; Mora et al., 2006).”
BackgroundProbiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
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Kumar, V., Ramnarayanan, K., Sundar, R., Padmanabhan, N., Srivastava, S., Koiwa, M., Yasuda, T., Koh, V., Huang, K. K., Tay, S. T., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0683 · Cited by 573
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
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Metadata
- Authors
- Gutzeit, C., Magri, G., & Cerutti, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Barcelona Biomedical Research Park (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Cerutti, Andrea
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2014-06-19
- Volume
- 260
- Issue
- 1
- Pages
- 76-85
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC4174397
- OpenAlex
- W2004499885
- Cited by
- 332
- References
- 101
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 43 · 2023: 31 · 2022: 29 · 2021: 33 · 2020: 41 · 2019: 29 · 2018: 24 · 2017: 25 · 2016: 18 · 2015: 8 · 2014: 5
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI96187, AI95613, AI61093)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- intestinal immunoglobulin A, IgA production, host-microbe interactions, gut microbiota, mucosal immunity, commensal tolerance, pathogen defense, epithelial cells, dendritic cells, lymphocytes, mucosal protection
- MeSH terms
- Animals, Antibody Formation, Homeostasis, Humans, Immunoglobulin A, Immune System, Intestinal Mucosa, Signal Transduction, T-Lymphocyte Subsets, Immunity, Mucosal, Microbiota
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