Cited by 335Gut microbiota and healthT-cell and B-cell ImmunologyImmune Response and Inflammation

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Intestinal IgA production and its role in host-microbe interaction

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Gutzeit, Cindy, Magri, Giuliana, Cerutti, Andrea·2014·Immunological Reviews

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Abstract

Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo-responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non-inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host-microbe interaction.

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Authors: Gutzeit, C., Magri, G., & Cerutti, A.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Barcelona Biomedical Research Park (ES)
Institució Catalana de Recerca i Estudis Avançats (ES)
Corresponding author: Cerutti, Andrea
ORCID: Gutzeit, Cindy
Magri, Giuliana
Cerutti, Andrea
Venue: Immunological Reviews
Publisher: Wiley
Published: 2014-06-19
Volume: 260
Issue: 1
Pages: 76-85
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12189
PMC: PMC4174397
OpenAlex: W2004499885
Cited by: 332
References: 101
Citations by year: 2026: 21 · 2025: 24 · 2024: 43 · 2023: 31 · 2022: 29 · 2021: 33 · 2020: 41 · 2019: 29 · 2018: 24 · 2017: 25 · 2016: 18 · 2015: 8 · 2014: 5
FWCI: 1.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI96187, AI95613, AI61093)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: intestinal immunoglobulin A, IgA production, host-microbe interactions, gut microbiota, mucosal immunity, commensal tolerance, pathogen defense, epithelial cells, dendritic cells, lymphocytes, mucosal protection
MeSH terms: Animals, Antibody Formation, Homeostasis, Humans, Immunoglobulin A, Immune System, Intestinal Mucosa, Signal Transduction, T-Lymphocyte Subsets, Immunity, Mucosal, Microbiota

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Intestinal IgA production and its role in host-microbe interaction

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