Cited by 294Dermatology and Skin DiseasesAsthma and respiratory diseasesContact Dermatitis and Allergies

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The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

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Han, Hongwei, Roan, Florence, Ziegler, Steven F.·2017·Immunological Reviews

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Abstract

Summary: Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell‐derived cytokines such as thymic stromal lymphopoietin ( TSLP ), IL ‐33, and IL ‐25 may drive the progression from atopic dermatitis to asthma and food allergy. This review focuses on current concepts of the role of skin barrier defects and epithelial cell‐derived cytokines in the initiation and maintenance of allergic inflammation and the atopic march.

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Authors: Han, H., Roan, F., & Ziegler, S. F.
Affiliations: Benaroya Research Institute (US)
University of Washington (US)
Corresponding author: Ziegler, Steven F.
ORCID: Han, Hongwei
Ziegler, Steven F.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2017-06-28
Volume: 278
Issue: 1
Pages: 116-130
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12546
PMC: PMC5492959
OpenAlex: W2728647913
Cited by: 285
References: 235
Citations by year: 2026: 18 · 2025: 18 · 2024: 27 · 2023: 25 · 2022: 41 · 2021: 39 · 2020: 42 · 2019: 39 · 2018: 28 · 2017: 8
FWCI: 5.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Foundation for the National Institutes of Health (R01AI068731, R01AI124220, U19AI125378)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: atopic march, atopic dermatitis, skin barrier dysfunction, thymic stromal lymphopoietin, IL-33, IL-25, allergen sensitization, allergic inflammation, asthma, food allergy, animal models
MeSH terms: Allergens, Animals, Dermatitis, Atopic, Environment, Epithelial Cells, Humans, Immune Tolerance, Immunization, Immunotherapy, Skin, Cytokines, Genetic Predisposition to Disease

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The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

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