Cited by 385Quantum Dots Synthesis And PropertiesNanoparticles: synthesis and applicationsPhotodynamic Therapy Research Studies

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On the Cyto‐Toxicity Caused by Quantum Dots

Shiohara, Amane, Hoshino, Akiyoshi, Hanaki, Ken‐ichi, Suzuki, Kazuo, Yamamoto, Kenji·2004·Microbiology and Immunology

DOI 10.1111/j.1348-0421.2004.tb03478.x

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Abstract

Quantum dots (QDs) such as CdSe QDs have been introduced as new fluorophores. The QDs conjugated with antibody are starting to be widely used for immunostaining. However there is still not sufficient analysis of the toxicity of QDs in the literature. Therefore we evaluated the cell damage caused by the quantum dots for biological applications. We performed cell viability assay to determine the difference in cell damage depending on the sizes and colors of mercapto‐undecanoic acid (MUA) QDs and the cell types. The results showed that the cell viability decreased with increasing concentration of MUA‐QDs. But in the case of Vero cell (African green monkey's kidney cell) with red fluorescence QD (QD640), the cell damage was less than for the others. Furthermore through the flow cytometry assay we found that this cell damage caused by MUA‐QD turned out to be cell death after 4‐6‐hr incubation. From the two assays described above, we found that there is a range of concentration of MUA‐QDs where the cell viability decreased without cell death occurring and thus we conclude that attention should be given when MUA‐QDs are applied to living organisms even in low concentrations.

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Authors: Shiohara, A., Hoshino, A., Hanaki, K., Suzuki, K., & Yamamoto, K.
Affiliations: National Institute of Infectious Diseases (JP)
Department of Medical Ecology and Informatics, Research Institute International Medical Center of Japan Shinjuku‐ku Tokyo 162‐8655 Japan
Corresponding author: Yamamoto, Kenji
ORCID: Hoshino, Akiyoshi
Hanaki, Ken‐ichi
Suzuki, Kazuo
Yamamoto, Kenji
Venue: Microbiology and Immunology
Publisher: Wiley
Published: 2004-09
Volume: 48
Issue: 9
Pages: 669-675
ISSN: 0385-5600 (ISSN-L)
1348-0421
DOI: 10.1111/j.1348-0421.2004.tb03478.x
OpenAlex: W2050289957
Semantic Scholar: ed1ee35465dc4e717235d9a635cb06e15cacd4ce
Cited by: 385
References: 31
Citations by year: 2026: 4 · 2025: 2 · 2024: 9 · 2023: 12 · 2022: 6 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 22 · 2014: 21 · 2013: 18 · 2012: 28
FWCI: 12.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3361 d)
Locations: Microbiology and Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords: quantum dots, cytotoxicity, CdSe quantum dots, cell viability, cell death, Vero cells, immunostaining, nanoparticle toxicity
MeSH terms: Animals, Cadmium, Cell Survival, Chlorocebus aethiops, Flow Cytometry, Fluorescent Dyes, HeLa Cells, Humans, Selenium, Sulfhydryl Compounds, Vero Cells, Cell Death, Hepatocytes, Quantum Dots

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On the Cyto‐Toxicity Caused by Quantum Dots

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