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Cited by 142Hepatitis C virus researchTreatment of Major DepressionTryptophan and brain disorders

Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C

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RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J. +5 more·2007·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2007.03316.x
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Abstract

SUMMARY: Background Whether antidepressants prevent depression during interferon‐alpha/ribavirin treatment for hepatitis C virus infection has yet to be established. Aim To investigate the use of paroxetine in a prospective, double‐blind, placebo‐controlled study for this indication. Methods Sixty‐one hepatitis C virus‐infected patients were randomly assigned to the antidepressant, paroxetine (n = 28), or placebo (n = 33), begun 2 weeks before and continued for 24 weeks during interferon‐alpha/ribavirin treatment. Primary endpoints included development of major depression and severity of depressive symptoms measured by the Montgomery Asberg Depression Rating Scale (MADRS). Results Rates of major depression during the study were low (17%) and did not differ between groups. Nevertheless, using published MADRS cut‐off scores, the percent of subjects who met criteria for mild, moderate or severe depression during interferon‐alpha/ribavirin therapy was significantly lower in paroxetine‐ vs. placebo‐treated subjects (P = 0.02, Fisher’s exact test). Assignment to paroxetine was also associated with significantly reduced depressive symptom severity. This effect was largely accounted for by participants with depression scores above the median (MADRS > 3) at baseline in whom paroxetine was associated with a maximal reduction in MADRS scores of 10.3 (95% CI: 2.1–18.5) compared with placebo at 20 weeks (P < 0.01). Study limitations included a small sample size and high drop‐out rate. Conclusion This double‐blind, placebo‐controlled trial provides preliminary data in support of antidepressant pre‐treatment in hepatitis C virus patients with elevated depressive symptoms at baseline.

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  • SSRIs alleviate cytokine-induced depression, with depressive and anxiety symptoms most responsive, while fatigue and neurovegetative symptoms are less responsive.

    “Interestingly, selective serotonin (5-HT) reuptake inhibitors (SSRIs) have been shown to alleviate cytokine-induced depression (Musselman et al., 2001a, Raison et al., 2007), and depressive and anxiety symptoms appear to be most responsive, while fatigue and neurovegetative symptoms are less responsive (Capuron et al., 2002, Raison et al., 2005b, McNutt et al., 2012).”

    From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Raison et al., 2007

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Authors
RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J., HENDERSON, M. A., REINUS, J. F., EVANS, D. L., ASNIS, G. M., & MILLER, A. H.
Affiliations
  • Emory University (US)
  • University of Pennsylvania (US)
  • Rush University Medical Center (US)
  • Kaiser Permanente (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
MILLER, A. H.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2007-03-20
Volume
25
Issue
10
Pages
1163-1174
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2007.03316.x
OpenAlex
W1482765914
Cited by
142
References
60
Citations by year
2025: 1 · 2024: 1 · 2022: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 23 · 2012: 17
FWCI
10.96
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • Pfizer
  • National Institutes of Health
  • National Institute of Mental Health (MH-00680, K23MH064619, MH 60723, MH 64619, R01MH060723, MH060723)
  • National Center for Research Resources (M01-RR00039, M01RR000039)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
paroxetine, antidepressant prophylaxis, depression prevention, interferon-alpha, ribavirin, hepatitis C, depressive symptoms, antiviral therapy adverse effects, Montgomery-Asberg Depression Rating Scale
MeSH terms
Adolescent, Adult, Aged, Antiviral Agents, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Ribavirin, Interferon-alpha, Paroxetine, Hepatitis C, Chronic

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