BAROREFLEX‐GOVERNED SYMPATHETIC OUTFLOW TO MUSCLE VASCULATURE IS INCREASED IN HYPOTHYROIDISM
Abstract
SUMMARY: Microelectrode recording of muscle nerve sympathetic activity (MSA), which is baroreflex‐governed and involved in cardiovascular homeostasis, was made in five patients with hypothyroidism and in seven patients with hyperthyroidism prior to treatment and after recovery to euthyroidism. Patients with hypothyroidism had a higher level of MSA when hypothyroid than after recovery (mean |Mp SEM 39.3 |Mp 7.1 and 26.8 |Mp 7.9 bursts/min, respectively, P < 0.05), whereas hyperthyroidism was not accompanied by a change in the number of sympathetic bursts/min. The response of MSA to manouvres known to influence the neural outflow via baroreceptors and other receptor inputs was not changed with altered thyroid function. The findings provide direct evidence of an increased sympathetic activity in hypothyroidism, but suggest that other physiological properties of MSA are intact in thyroid disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
General Characteristics of Sympathetic Activity in Human Muscle Nerves
Delius, W., Hagbarth, K. ‐., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05157.x · Cited by 831 · see citing works
Mark, A. L., Victor, R. G., Nerhed, C., & Wallin, B. G. (1985) · Circulation Research · doi:10.1161/01.res.57.3.461 · Cited by 748 · see citing works
Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age
Sundlöf, G., & Wallin, B. G. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012170 · Cited by 601 · see citing works
Effects of the cold pressor test on muscle sympathetic nerve activity in humans.
Victor, R. G., Leimbach, W. N., Seals, D. R., Wallin, B. G., & Mark, A. L. (1987) · Hypertension · doi:10.1161/01.hyp.9.5.429 · Cited by 519 · see citing works
The variability of muscle nerve sympathetic activity in resting recumbent man
Sundlöf, G., & Wallin, B. G. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012050 · Cited by 442 · see citing works
Bilezikian, J. P., & Loeb, J. N. (1983) · Endocrine Reviews · doi:10.1210/edrv-4-4-378 · Cited by 354 · see citing works
Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man
WALLIN, B. G., SUNDLÖF, G., ERIKSSON, B., DOMINIAK, P., GROBECKER, H., & LINDBLAD, L. E. (1981) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1981.tb06706.x · Cited by 316 · see citing works
Manoeuvres affecting sympathetic outflow in human muscle nerves
Delius, W., Hagbarth, K. ‐., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05158.x · Cited by 316 · see citing works
Peripheral Sympathetic Neural Activity in Conscious Humans
Wallin, B. G., & Fagius, J. (1988) · Annual Review of Physiology · doi:10.1146/annurev.ph.50.030188.003025 · Cited by 293 · see citing works
Self-citationRespiratory modulation of muscle sympathetic and vagal cardiac outflow in man.
Eckberg, D. L., Nerhed, C., & Wallin, B. G. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015766 · Cited by 278 · see citing works
Plasma Noradrenaline and Adrenaline in Patients with Thyrotoxicosis and Myxoedema
Christensen, N. J. (1973) · Clinical Science · doi:10.1042/cs0450163 · Cited by 208 · see citing works
SYMPATHETIC OUTFLOW IN MAN AFTER ANAESTHESIA OF THE GLOSSOPHARYNGEAL AND VAGUS NERVES
Fagius, J., Wallin, B. G., Sundlöf, G., Nerhed, C., & Englesson, S. (1985) · Brain · doi:10.1093/brain/108.2.423 · Cited by 182 · see citing works
Self-citationFagius, J., Karhuvaara, S., & Sundlöf, G. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08760.x · Cited by 174 · see citing works
Self-citationBaroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans
Eckberg, D. L., Rea, R. F., Andersson, O., Hedner, T., Pernow, J., Lundberg, J. M., & Wallin, B. G. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08401.x · Cited by 171 · see citing works
COULOMBE, P., DUSSAULT, J. H., & WALKER, P. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-6-1185 · Cited by 170 · see citing works
Plasma catecholamines in hypothyroidism and hyperthyroidism
STOFFER, S. S., JIANG, N.-S., GORMAN, C. A., & PIKLER, G. M. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-3-587 · Cited by 137 · see citing works
Plasma catecholamine concentrations in hyperthyroidism and hypothyroidism
Coulombe, P., Dussault, J. H., & Walker, P. (1976) · Metabolism · doi:10.1016/0026-0495(76)90126-8 · Cited by 132 · see citing works
The diving response in man: effects on sympathetic activity in muscle and skin nerve fascicles.
Fagius, J., & Sundlöf, G. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016196 · Cited by 131 · see citing works
Self-citationSympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans
Wallin, B. G., & Eckberg, D. L. (1982) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1982.242.2.h185 · Cited by 119 · see citing works
Increased Levels of Plasma Noradrenaline in Hypothyroidism
Christensen, N. J. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-3-359 · Cited by 114 · see citing works
Landsberg, L., & Axelrod, J. (1968) · Circulation Research · doi:10.1161/01.res.22.5.559 · Cited by 107 · see citing works
Sympathetic outflow to muscles during treatment of hypertension with metoprolol
Wallin, B. G., Sundlöf, G., Strömgren, E., & Aberg, H. (1984) · Hypertension · doi:10.1161/01.hyp.6.4.557 · Cited by 86 · see citing works
Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man
Mörlin, C., Wallin, B. G., & Eriksson, B. M. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb07315.x · Cited by 85 · see citing works
Sympathetic Outflow in Human Muscle Nerves Increases During Hypoglycemia
Fagius, J., Niklasson, F., & Berne, C. (1986) · Diabetes · doi:10.2337/diab.35.10.1124 · Cited by 71 · see citing works
Self-citationMICRONEUROGRAPHIC EVIDENCE OF EXCESSIVE SYMPATHETIC OUTFLOW IN THE GUILLAIN-BARRÉ SYNDROME
Fagius, J., & Wallin, B. G. (1983) · Brain · doi:10.1093/brain/106.3.589 · Cited by 67 · see citing works
Self-citationProspective study of symptoms after human microneurography
Eckberg, D. L., Wallin, B. G., Fagius, J., Lundberg, L. E. R., & Torebjörk, H. E. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08804.x · Cited by 51 · see citing works
Self-citationIncreased sympathetic tone in forearm subcutaneous tissue in primary hypothyroidism
Nielsen, H. V., Hasselström, K., Feldt‐Rasmussen, U., Mehlsen, J., Siersbæk‐Nielsen, K., Friis, T., Haunsø, S., & Trap‐Jensen, J. (1987) · Clinical Physiology · doi:10.1111/j.1475-097x.1987.tb00172.x · Cited by 19 · see citing works
SECTION VIII. TRH IN SHOCK AND SPINAL TRAUMA: Effects of TRH on Blood flow and the Microcirculation
Koskinen, L. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb46657.x · Cited by 16 · see citing works
Tsunoda, S.-I., Shiozawa, Z., & Mano, T. (1988) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(88)90095-1 · Cited by 13 · see citing works
Effects of thyroid replacement therapy on catecholamine plasma levels
Mannelli, M., Gheri, R. G., Feo, M. L. D., et al. (1983) · Journal of Endocrinological Investigation · doi:10.1007/bf03347596 · Cited by 7 · see citing works
CHANGES IN BLOOD PRESSURE AND PLASMA NORADRENALINE IN SHORT‐TERM HYPOTHYROIDISM
Brown, R. T., Lakshmanan, M. C., Baucom, C. E., & Polinsky, R. J. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00268.x · Cited by 5 · see citing works
[Plasma noradrenaline in hyperthyroidism and hypothyroidism].
Premel-Cabic, A., Gétin, F., Turcant, A., et al. (1986) · PubMed · Cited by 5 · see citing works
Ratge, D., Barthels, U., Wisser, H., et al. (1987) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1987.25.7.393 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- 10.1111/j.1749-6632.1989.tb54503.x · DOI
- Premal‐Cabic A., 1986, Noradrénaline plasmatique dans l'hyperthyroïde et l'hypothyroïdie, Presse Médicale, 15, 1625
- Utiger R. D., 1989, Endocrinology, 702
Cited by
Sorted by citations
Fagius, J., & Wallin, B. G. (1993) · Clinical Autonomic Research · doi:10.1007/bf01826234 · Cited by 227 · see citing works
Self-citation
- Authors
- FAGIUS, J., WESTERMARK, K., & KARLSSON, A.
- Affiliations
- Uppsala University Hospital (SE)
- Corresponding author
- FAGIUS, JAN
- ORCID
- FAGIUS, JAN
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1990-08
- Volume
- 33
- Issue
- 2
- Pages
- 177-186
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2052733400
- Semantic Scholar
- 87a300fbc1da1988730cf3a9be4b6dc5d9f63d3e
- Cited by
- 30
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- hypothyroidism, hyperthyroidism, baroreflex, sympathetic outflow, thyroid function, cardiovascular homeostasis
- MeSH terms
- Adult, Aged, Electrocardiography, Female, Heart Rate, Humans, Hyperthyroidism, Hypothyroidism, Male, Microelectrodes, Middle Aged, Muscles, Pressoreceptors, Sympathetic Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
