The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Detection of somatic β-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
Open accessAbstract
BACKGROUND: Primary pigmented nodular adrenocortical disease (PPNAD) leads to Cushing syndrome (CS) and is often associated with Carney complex (CNC). Genetic alterations of the type 1-alpha regulatory subunit of cAMP-dependent protein kinase A (PRKAR1A) and phosphodiesterase 11A4 (PDE11A) genes have been found in PPNAD. Recent studies have demonstrated that beta-catenin mutations are frequent in adrenocortical adenomas and carcinomas and that the Wnt-signalling pathway is involved in PPNAD tumorigenesis. We hypothesized that adrenocortical adenomas that form in the context of PPNAD may harbour beta-catenin mutations. METHODS: We studied 18 patients with CS secondary to PPNAD who were screened for germline PRKAR1A and PDE11A mutations. Tumor DNA was extracted from pigmented adrenocortical adenoma and nodular adrenal hyperplasia. Mutation analysis of exons 3 and 5 of beta-catenin was performed using polymerase chain reaction and direct sequencing. Sections from formalin-fixed, paraffin-embedded tumour samples were studied by immunohistochemistry with an antibody against beta-catenin. RESULTS: Nine patients were carrying germline PRKAR1A mutations and one patient had a PDE11A mutation. We found somatic beta-catenin mutations in 2 of 18 patients (11%). In both cases, the mutations occurred in relatively large adenomas that had formed in the background of PPNAD. Tumor DNA analysis revealed a heterozygous ACC-to-GCC missense mutation in codon 41 (T41A) and a TCT-to-CCT missense mutation in codon 45 (S45P) of exon 3 of the beta-catenin gene that was confirmed at the cDNA level. There were no alterations in the DNA of PPNAD-adjacent tissues and lymphocytes from the patients, indicating somatic events. Immunohistochemistry showed nuclear accumulation of beta-catenin in more than 90% of cells in adenomatous tissue whereas no nuclear immunoreactivity was detected in adjacent PPNAD nodular cells. Nuclear translocation of beta-catenin protein in the PPNAD adenoma suggests activation of the Wnt-beta-catenin pathway in PPNAD. CONCLUSIONS: We report, for the first time, beta-catenin mutations in adenomas associated with PPNAD, further implicating Wnt-beta-catenin signalling in tumorigenesis linked to bilateral adrenal hyperplasias.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“mutational analysis of the effector of the canonical Wnt pathway, the β-catenin gene, CTNNB1, has identified activating point mutations in over 25% of both ACAs and ACCs in children and adults (149, 206–208).”
From Adrenocortical carcinoma (2014) · cites this paper as [207]
In the citing paper
“Furthermore, mutational analysis of the β-catenin gene CTNNB1 identified activating point mutations in both ACAs and ACCs (149, 206–208).”
From Adrenocortical carcinoma (2014) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Kirschner, L. S., Carney, J. A., Pack, S. D., Taymans, S. E., Giatzakis, C., Cho, Y. S., Cho-Chung, Y. S., & Stratakis, C. A. (2000) · Nature Genetics · doi:10.1038/79238 · Cited by 1,153
Self-citationStratakis, C. A., Kirschner, L. S., & Carney, J. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7903 · Cited by 805
Self-citationWnt signaling in the intestinal epithelium: from endoderm to cancerPreprint
Gregorieff, A., & Clevers, H. C. (2005) · Genes & Development · doi:10.1101/gad.1295405 · Cited by 692
β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628
β-Catenin mutations in cell lines established from human colorectal cancers
Ilyas, M., Tomlinson, I. P. M., Rowan, A., Pignatelli, M. N., & Bodmer, W. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10330 · Cited by 494
Cited by
Sorted by citations
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892
Berthon, A. S., Sahut‐Barnola, I., Lambert-Langlais, S., de Joussineau, C., Damon‐Soubeyrand, C., Louiset, E., Taketo, M. M., Tissier, F., Bertherat, J. Y., Lefrançois‐Martinez, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq029 · Cited by 263
Berthon, A. S., Drelon, C., Ragazzon, B., Boulkroun, S., Tissier, F., Amar, L., Samson-Couterie, B., Zennaro, M., Plouin, P., Skah, S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt484 · Cited by 223
Gadelha, M. R., Gatto, F., Wildemberg, L. E., & Fleseriu, M. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01961-x · Cited by 183
Heaton, J. H., Wood, M. A., Kim, A. C., Lima, L. O., Barlaskar, F. M., Almeida, M. Q., Fragoso, M. C. B. V., Kuick, R., Lerario, A. M., Simon, D. P., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.05.026 · Cited by 173
The Wnt/beta-catenin pathway in adrenocortical development and cancer
El Wakil, A., & Lalli, E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.014 · Cited by 134
Bonnet, S., Gaujoux, S., Launay, P., Baudry, C., Chokri, I., Ragazzon, B., Libé, R., René-Corail, F., Audebourg, A., Vacher-Lavenu, M.-C., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1885 · Cited by 133
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
Drelon, C., Berthon, A., Sahut-Barnola, I., Mathieu, M., Dumontet, T., Rodriguez, S., Batisse-Lignier, M., Tabbal, H., Tauveron, I., Lefrançois-Martinez, A.-M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12751 · Cited by 128
Self-citationWnt/β-catenin signalling in adrenal physiology and tumour development
Berthon, A., Martinez, A., Bertherat, J., & Val, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.009 · Cited by 125
Salpea, P., & Stratakis, C. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.022 · Cited by 121
Self-citationGaujoux, S., Pinson, S., Gimenez‐Roqueplo, A., Amar, L., Ragazzon, B., Launay, P., Méatchi, T., Libé, R., BERTAGNA, X. Y., Audebourg, A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1497 · Cited by 121
Clinical and molecular genetics of Carney complex
Rothenbühler, A., & Stratakis, C. A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.03.003 · Cited by 110
Self-citationNew targets and therapeutic approaches for endocrine malignancies☆
Fassnacht, M., Kreissl, M. C., Weismann, D., & Allolio, B. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.013 · Cited by 104
Bourdeau, I., El Ghorayeb, N., Gagnon, N., & Lacroix, A. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0296 · Cited by 98
Self-citationMEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics
Schernthaner-Reiter, M. H., Trivellin, G., & Stratakis, C. A. (2015) · Neuroendocrinology · doi:10.1159/000371819 · Cited by 98
Self-citationRodríguez, F. J., Stratakis, C. A., & Evans, D. G. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0935-7 · Cited by 84
Self-citationSteroidogenesis—Adrenal Cell Signal Transduction
Gallo‐Payet, N., & Battista, M. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130050 · Cited by 87
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Almeida, M. Q., & Stratakis, C. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.018 · Cited by 85
Self-citationAnselmo, J., Medeiros, S., Carneiro, V., Greene, E., Levy, I., Nesterova, M., Lyssikatos, C., Horvath, A., Carney, J. A., & Stratakis, C. A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2244 · Cited by 81
Self-citationGenetics of tumors of the adrenal cortex
Bonnet-Serrano, F., & Bertherat, J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0361 · Cited by 80
Carney complex and other conditions associated with micronodular adrenal hyperplasias
Almeida, M. Q., & Stratakis, C. A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.006 · Cited by 80
Self-citationAlmeida, M. Q., Azevedo, M. F., Xekouki, P., Bimpaki, E. I., Horvath, A., Collins, M. T., Karaviti, L. P., Jeha, G. S., Bhattacharyya, N., Cheadle, C., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3000 · Cited by 72
Self-citationAdrenocortical tumorigenesis: Lessons from genetics
Kamilaris, C. D. C., Hannah‐Shmouni, F., & Stratakis, C. A. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101428 · Cited by 71
Self-citationde Krijger, R. R., & Papathomas, T. G. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1166-y · Cited by 67
REVIEW PAPER: Origin and Molecular Pathology of Adrenocortical Neoplasms
Bielińska, M., Parviainen, H., Kiiveri, S., Heikinheimo, M., & Wilson, D. B. (2009) · Veterinary Pathology · doi:10.1354/vp.08-vp-0179-w-rev · Cited by 68
Juhlin, C. C., Bertherat, J. Y., Giordano, T. J., Hammer, G. D., Sasano, H., & Mete, Ö. (2021) · Endocrine Pathology · doi:10.1007/s12022-021-09667-0 · Cited by 63
The cAMP pathway and the control of adrenocortical development and growth
de Joussineau, C., Sahut‐Barnola, I., Levy, I., Saloustros, E. S., Val, P., Stratakis, C. A., & Martinez, A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.006 · Cited by 62
Self-citationAlmeida, M. Q., Muchow, M., Boikos, S. A., Bauer, A. J., Griffin, K., Tsang, K. M., Cheadle, C., Watkins, T., Wen, F., Starost, M. F., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq014 · Cited by 59
Self-citationPathogenesis of adrenocortical cancer
Bertherat, J. Y., & BERTAGNA, X. Y. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.006 · Cited by 55
Cushing Syndrome in Carney Complex
Lowe, K. M., Young, W. F., Lyssikatos, C., Stratakis, C. A., & Carney, J. A. (2016) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000748 · Cited by 54
Self-citationAdrenal cortex tissue homeostasis and zonation: A WNT perspective
Drelon, C., Berthon, A. S., Mathieu, M., Martinez, A., & Val, P. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.014 · Cited by 64
Almeida, M. Q., Harran, M. D., Bimpaki, E. I., Hsiao, H., Horvath, A., Cheadle, C., Watkins, T., Nesterova, M., & Stratakis, C. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2420 · Cited by 51
Self-citationAdrenocortical hyperplasia: A multifaceted disease
Bourdeau, I., Parisien-La Salle, S., & Lacroix, A. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101386 · Cited by 48
Self-citationGenetic aspects of adrenocortical tumours and hyperplasias
Mazzuco, T. L., Durand, J., Chapman, A., Crespigio, J., & Bourdeau, I. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04403.x · Cited by 47
Self-citationRole of unilateral adrenalectomy in bilateral adrenal hyperplasias with Cushing’s syndrome
Meloche‐Dumas, L., Mercier, F., & Lacroix, A. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101486 · Cited by 47
Pathophysiological aspects of Wnt-signaling in endocrine disease
Schinner, S., Willenberg, H. S., Schott, M., & Scherbaum, W. A. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0831 · Cited by 47
Funder, J. W. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12935 · Cited by 46
The Genetics of Adrenocortical Tumors
Espiard, S., & Bertherat, J. Y. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.004 · Cited by 47
Stratakis, C. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.015 · Cited by 38
Self-citationVezzosi, D., Tenenbaum, F., Cazabat, L., Tissier, F., Bienvenu, M., Carrasco, C. A., Laloi-Michelin, M., Barrande, G., Lefèbvre, H., Hiéronimus, S., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2174 · Cited by 38
Molecular Genetic and Genomic Alterations in Cushing’s Syndrome and Primary Aldosteronism
Kamilaris, C. D. C., Stratakis, C. A., & Hannah‐Shmouni, F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.632543 · Cited by 36
Self-citationAlterations of Phosphodiesterases in Adrenocortical Tumors
Hannah‐Shmouni, F., Faucz, F. R., & Stratakis, C. A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00111 · Cited by 36
Self-citationMolecular Basis of Primary Aldosteronism and Adrenal Cushing Syndrome
Vaduva, P., Bonnet-Serrano, F., & Bertherat, J. Y. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa075 · Cited by 35
The molecular basis of adrenocortical cancer
Lehmann, T. P., & Wrzesiński, T. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.02.009 · Cited by 34
Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia
Penny, M. K., Finco, I., & Hammer, G. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.005 · Cited by 31
Bilateral Adrenal Hyperplasia: Pathogenesis and Treatment
Chevalier, B., Vantyghem, M., & Espiard, S. (2021) · Biomedicines · doi:10.3390/biomedicines9101397 · Cited by 30
Adrenocortical carcinoma in patients with MEN1: a kindred report and review of the literature
Wang, W., Han, R., Ye, L., Xie, J., Tao, B., Sun, F., Zhuo, R., Chen, X., Deng, X., Ye, C., et al. (2019) · Endocrine Connections · doi:10.1530/ec-18-0526 · Cited by 29
Identification of Genetic Alterations of AXIN2 Gene in Adrenocortical Tumors
Chapman, A., Durand, J., Ouadi, L., & Bourdeau, I. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2987 · Cited by 28
Self-citationHofland, J., de Herder, W. W., Derks, L., Hofland, L. J., van Koetsveld, P. M., de Krijger, R. R., van Nederveen, F. H., Horvath, A., Stratakis, C. A., de Jong, F. H., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0594 · Cited by 26
Self-citationGenetics of micronodular adrenal hyperplasia and Carney complex
Tirosh, A., Valdés, N., & Stratakis, C. A. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.07.005 · Cited by 26
Self-citationCastro, M. A., & Marazuela, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.913253 · Cited by 23
Phosphodiesterases and Adrenal Cushing in Mice and Humans
Szarek, E., & Stratakis, C. A. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1389916 · Cited by 21
Self-citationMitsui, Y., Yasumoto, H., Nagami, T., Hiraki, M., Arichi, N., Ishikawa, N., Araki, A., Maruyama, R., Tanaka, Y., Dahiya, R., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1889 · Cited by 20
Genetic Alterations in Benign Adrenal Tumors
Pitsava, G., & Stratakis, C. A. (2022) · Biomedicines · doi:10.3390/biomedicines10051041 · Cited by 20
Self-citationUpdate on primary micronodular bilateral adrenocortical diseases
Maillet, M., Bourdeau, I., & Lacroix, A. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000538 · Cited by 17
Self-citationBalderrama-Brondani, V., Lacombe, A. M. F., Mariani, B. M. P., Montenegro, L. R., Soares, I. C., Neto, J. E. B., Tanno, F. Y., Srougi, V., Chambo, J. L., Mendonca, B. B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031238 · Cited by 17
Rare diseases in clinical endocrinology: a taxonomic classification system
Marcucci, G., Cianferotti, L., Beck‐Peccoz, P., Capezzone, M., Cetani, F., Colao, A., Davì, M. V., Uberti, E. C. D., Prato, S. D., Elisei, R., et al. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0202-6 · Cited by 15
Primary Pigmented Nodular Adrenocortical Disease
Carney, J. A., Libé, R., Bertherat, J. Y., & Young, W. F. (2014) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000220 · Cited by 14
Insights into the role of genetic alterations in adrenocortical tumorigenesis
Herbet, M., Feige, J., & Thomas, M. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.010 · Cited by 13
Disorders of the adrenal cortex: Genetic and molecular aspects
Pitsava, G., Maria, A. G., & Faucz, F. R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.931389 · Cited by 13
Sun, J., Ding, L., He, L., Fu, H., Li, R., Feng, J., Dong, J., & Liao, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1356870 · Cited by 12
Azevedo, M. F., & Stratakis, C. A. (2011) · Endocrine Practice · doi:10.4158/ep10412.ra · Cited by 15
Self-citationARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing’s syndrome
Maria, A. G., Tatsi, C., Berthon, A. S., Drougat, L., Settas, N., Hannah‐Shmouni, F., Bertherat, J. Y., Faucz, F. R., & Stratakis, C. A. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0273 · Cited by 12
Self-citationKamilaris, C. D. C., Faucz, F. R., Andriessen, V. C., Nilubol, N., Lee, C. R., Ahlman, M. A., Hannah‐Shmouni, F., & Stratakis, C. A. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab007 · Cited by 10
Self-citationAdrenocortical Growth and Cancer
Lefèvre, L., Bertherat, J. Y., & Ragazzon, B. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140010 · Cited by 12
Treatment of Primary Pigmented Nodular Adrenocortical Disease
Gang, X., Wang, G., Liu, X., Zhang, S., & Guo, Y. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1948-6990 · Cited by 10
Soon, P. S. H., & Sidhu, S. B. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0857-5_11 · Cited by 9
Pusantisampan, T., Sangkhathat, S., Kayasut, K., Kanngurn, S., Jaruratanasirikul, S., Chotsampancharoen, T., & Kritsaneepaiboon, S. (2009) · Pediatric and Developmental Pathology · doi:10.2350/09-07-0683-cr.1 · Cited by 9
Pathogenesis of benign adrenocortical tumors
Vezzosi, D., Bertherat, J. Y., & Groussin, L. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.005 · Cited by 7
Kubo, H., Tsurutani, Y., Sugisawa, C., Sunouchi, T., Hirose, R., & Saito, J. (2022) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2022.j051 · Cited by 5
Molecular and Genetics Perspectives on Primary Adrenocortical Hyperfunction Disorders
Kim, S., Chaudhary, P. K., & Kim, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111341 · Cited by 4
Adrenal Cortex Tumors and Hyperplasias
Pignatelli, D. (2011) · InTech eBooks · doi:10.5772/19108 · Cited by 4
Schwafertz, C., Schinner, S., Kühn, M. C., Haase, M., Asmus, A., Mülders-Opgenoorth, B., Ansurudeen, I., Hornsby, P. J., Morawietz, H., Oetjen, E., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.015 · Cited by 3
PPNAD, Carney Complex, and Other Micronodular Adrenal Hyperplasia
Espiard, S., & Bertherat, J. Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64321-0 · Cited by 3
WNT pathway deregulation in adrenal cortex tumorigenesis
Wilmouth, J., Olabe, J., Roucher‐Boulez, F., & Val, P. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.08.016 · Cited by 2
Pathophysiology and Genetic Landscape of Adrenocortical Tumors and Hyperplasias
Ghorayeb, N. E., Bourdeau, I., & Lacroix, A. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-62470-9_7 · Cited by 2
Self-citationIdentification of Cushing's syndrome (CS) and its history from Harvey Cushing to today
Poirier, J., Martel‐Duguech, L., Bourdeau, I., & Lacroix, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-96100-4.00012-0 · Cited by 1
Self-citationA Novel PRKAR1A Gene Mutation Associated With Primary Pigmented Nodular Adrenocortical Disease
Ran, H., Ma, X., Wang, Q., Xie, Z., & Qin, G. (2014) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000296 · Cited by 1
WNT/β-Catenin Signaling in Adrenocortical Carcinoma
Gaujoux, S., Tissier, F., & Bertherat, J. Y. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_16 · Cited by 1
Quoi de neuf en pathologie corticosurrénalienne bilatérale ?
Tissier, F. (2008) · Annales de Pathologie · doi:10.1016/j.annpat.2008.09.008 · Cited by 1
Genetics of Benign Adrenocortical Tumors
Hannah‐Shmouni, F., & Stratakis, C. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_3 · Cited by 1
Self-citationNew Strategies for the Treatment of Adrenocortical Carcinoma
Kirschner, L. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_30
PDE11A (phosphodiesterase 11A)
Libé, R., & Bertherat, J. Y. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44886
Benign and Malignant Diseases of the Adrenal Cortex
McNicol, A. M. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-1707-2_21
Local Control of Steroid Hormone Biosynthesis
Hofland, J. (2012) · EUR Research Repository (Erasmus University Rotterdam)
Detection of somatic β-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
SCHTEINGART, D. E. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79408-9
Genetics of Adrenocortical Cancers
Assié, G., & Bertherat, J. Y. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_4
21and Malignant Diseases of the Adrenal Cortex
Couvelard, A. (2010)
Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome
Ghorayeb, N. E., Bourdeau, I., & Lacroix, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-45950-9_4
Self-citationSomatic β-Catenin Gene Mutations and WNT Signaling in Adrenal Tumors
Bourdeau, I. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64311-8
Self-citationPhan, A. T., Habra, M. A., Grubbs, E. G., & Moran, C. A. (2012) · Wiley eBooks · doi:10.1002/9781118464557.ch10
Primary Pigmented Nodular Adrenocortical Disease
Nosé, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-52480-3.50088-3
Nosé, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-52480-3.50077-9
Molecular tools for diagnosing diseases of the adrenal cortex
Faucz, F. R., Maria, A. G., & Stratakis, C. A. (2023) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000809
Self-citationThe Hormonal Status Comparison of Unilateral and Bilateral Adrenal Adenomas: Are They the Same?
Özbaş, B., Canpolat, A. G., Özbaş, C., Çorapçıoğlu, D., & Şahi̇n, M. (2023) · European Journal of Therapeutics · doi:10.58600/eurjther665
PPNAD, Carney complex, and other micronodular adrenal hyperplasia
Vaduva, P., Espiard, S., & Bertherat, J. Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00124-2
Adrenal Cortical Nodular Diseases
(2024) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477473-04
Somatic β-catenin gene mutations and WNT signaling in adrenal tumors
Perreault, F., & Bourdeau, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00335-6
Self-citationRôle de la voie Wnt/ßcaténine dans la physiopathologie de la cortico-surrénale
Berthon, A. S. (2012) · theses.fr (ABES) · doi:10.70675/f153e745z2e77z4090zac69zb5d4866fd8bf
Metadata
- Authors
- Tadjine, M., Lampron, A., Ouadi, L., Horvath, A., Stratakis, C. A., & Bourdeau, I.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- National Institutes of Health (US)
- Corresponding author
- Bourdeau, Isabelle
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2008-08-13
- Volume
- 69
- Issue
- 3
- Pages
- 367-373
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- PMC
- PMC3138207
- OpenAlex
- W2089127970
- Cited by
- 108
- References
- 27
- Citations by year
- 2026: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 8
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD000642)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- Cushing's syndrome, Wnt/β-catenin signaling, adrenal adenoma, Carney complex, PRKAR1A mutation, nuclear β-catenin
- MeSH terms
- Adenoma, Adolescent, Adrenal Cortex Diseases, Adrenal Cortex Neoplasms, Adult, Child, Child, Preschool, DNA Mutational Analysis, Female, Genetic Testing, Humans, Male, Middle Aged, Mutation, Phosphoric Diester Hydrolases, Pigmentation Disorders, 3',5'-Cyclic-GMP Phosphodiesterases, beta Catenin, Cyclic AMP-Dependent Protein Kinase RIalpha Subunit, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
