Wnt/β-catenin signalling in adrenal physiology and tumour development
Abstract
Wnt/β-catenin signalling plays essential roles during embryonic development and in adult tissue homeostasis. Canonical signalling through Wnt secreted ligands relies on the control of β-catenin cytoplasmic accumulation and translocation to the nucleus. In this compartment, β-catenin serves as a transcription coactivator for transcription factors such as Lef/Tcf or some nuclear receptors. Constitutive Wnt signalling resulting from inactivation of inhibitors of the pathway or from activating mutations in β-catenin, triggers tumour development in a number of tissues. Analysis of patients' samples and genetically engineered mouse models has shown that Wnt signalling was involved in adrenal development and tumourigenesis. This review will summarise all these recent findings and will focus on some of the mechanisms that may lead to aberrant accumulation of β-catenin in adrenocortical tumours.
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High-grade ACCs are enriched for mutations of TP53 and/or CTNNB1, and these mutations tend to be mutually exclusive.
“High-grade ACCs are enriched for mutations of TP53 (14, 140–142) and/or CTNNB1 (143–149), and these mutations tend to be mutually exclusive (reviewed in Ref. 150).”
From Adrenocortical carcinoma (2014) · cites this paper as [144]
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Adrenocortical cancer and IGF2: is the game over or our experimental models limited?
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Self-citation
- Authors
- Berthon, A., Martinez, A., Bertherat, J., & Val, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Val, Pierre
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 351
- Issue
- 1
- Pages
- 87-95
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2012008624
- Cited by
- 125
- References
- 117
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 14 · 2014: 17 · 2013: 16 · 2012: 6
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- Wnt/β-catenin signaling, adrenal development, adrenocortical tumors, β-catenin nuclear accumulation, TCF/LEF transcription factors, nuclear receptors, tumourigenesis, genetic mouse models, adrenal physiology
- MeSH terms
- Adrenal Gland Neoplasms, Animals, Cell Nucleus, Cell Transformation, Neoplastic, Cytoplasm, Humans, Neoplasm Proteins, Neoplasms, Experimental, Active Transport, Cell Nucleus, Wnt Proteins, beta Catenin, Mice, TCF Transcription Factors, Wnt Signaling Pathway
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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