Cited by 125Wnt/β-catenin signaling in development and cancerAdrenal and Paraganglionic TumorsSignaling Pathways in Disease

Wnt/β-catenin signalling in adrenal physiology and tumour development

Berthon, Annabel, Martinez, Antoine, Bertherat, Jérôme, Val, Pierre·2012·Molecular and Cellular Endocrinology

Abstract

Wnt/β-catenin signalling plays essential roles during embryonic development and in adult tissue homeostasis. Canonical signalling through Wnt secreted ligands relies on the control of β-catenin cytoplasmic accumulation and translocation to the nucleus. In this compartment, β-catenin serves as a transcription coactivator for transcription factors such as Lef/Tcf or some nuclear receptors. Constitutive Wnt signalling resulting from inactivation of inhibitors of the pathway or from activating mutations in β-catenin, triggers tumour development in a number of tissues. Analysis of patients' samples and genetically engineered mouse models has shown that Wnt signalling was involved in adrenal development and tumourigenesis. This review will summarise all these recent findings and will focus on some of the mechanisms that may lead to aberrant accumulation of β-catenin in adrenocortical tumours.

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Crossref · 10.1016/j.mce.2011.09.009

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  • High-grade ACCs are enriched for mutations of TP53 and/or CTNNB1, and these mutations tend to be mutually exclusive.

    “High-grade ACCs are enriched for mutations of TP53 (14, 140–142) and/or CTNNB1 (143–149), and these mutations tend to be mutually exclusive (reviewed in Ref. 150).”

    From Adrenocortical carcinoma (2014) · cites this paper as [144]

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Authors
Berthon, A., Martinez, A., Bertherat, J., & Val, P.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Val, Pierre
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2012-03
Volume
351
Issue
1
Pages
87-95
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2012008624
Cited by
125
References
117
Citations by year
2026: 2 · 2025: 4 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 14 · 2014: 17 · 2013: 16 · 2012: 6
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
Wnt/β-catenin signaling, adrenal development, adrenocortical tumors, β-catenin nuclear accumulation, TCF/LEF transcription factors, nuclear receptors, tumourigenesis, genetic mouse models, adrenal physiology
MeSH terms
Adrenal Gland Neoplasms, Animals, Cell Nucleus, Cell Transformation, Neoplastic, Cytoplasm, Humans, Neoplasm Proteins, Neoplasms, Experimental, Active Transport, Cell Nucleus, Wnt Proteins, beta Catenin, Mice, TCF Transcription Factors, Wnt Signaling Pathway

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