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Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis
Abstract
OBJECTIVE: Epicardial adipose tissue (EAT) is a part of visceral fat deposited around the heart between the pericardium and myocardium along the distribution of coronary arteries. EAT thickness is reported to be associated with coronary atherosclerosis; however, no study has measured EAT volume in patients with type 2 diabetes or investigate its association with coronary artery disease. DESIGN: A hospital-based case control study. PATIENTS: A total of 49 patients with type 2 diabetes mellitus (T2DM) and 78 nondiabetic controls were studied. MEASUREMENTS: Cardiac multislice computed tomography was used to measure EAT volume, Gensini score, coronary artery calcium score and, coronary lesions. The relationships between EAT volume, markers of coronary atherosclerosis and anthropometric and biochemical parameters of metabolic syndrome (MetS) were investigated. RESULTS: EAT volume was significantly higher in patients with T2DM than in nondiabetic subjects (166.1 +/- 60.6 cm(3) vs. 123.4 +/- 41.8 cm(3), P < 0.0001). Logistic regression analysis revealed independent and significant associations between EAT and diabetic status. EAT volume was significantly associated with components of MetS (BMI, waist circumference, fasting serum glucose, total cholesterol, HDL-cholesterol, and triglycerides levels), Gensini score, coronary lesions, coronary disease and coronary calcium scores. Univariate, multivariate and trend analyses confirmed that EAT volume was associated with MetS component clustering and the coronary atherosclerosis index. CONCLUSIONS: The analytical results indicate that EAT volume is increased in T2DM patients and is associated with unfavourable components of MetS and coronary atherosclerosis. The close anatomical relationship between EAT and the coronary arteries, combined with other evidence indicating that EAT is a biologically active adipokine-secreting tissue, suggest that EAT participates in the pathogenesis of diabetic coronary atherosclerosis.
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“On the other hand, diabetic patients often exhibit an abnormally expanded EAT, usually in association with obesity and metabolic syndrome in both T2DM and T1DM [19,20,21,22].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [21]
In the citing paper
“Various studies indicate that an enlarged EAT mass in T2DM is associated with obesity and metabolic syndrome and its components [21,56].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [21]
Citations
Cites
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
A more meaningful scoring system for determining the severity of coronary heart disease
Gensini, G. G. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80105-2 · Cited by 2,198
Human epicardial adipose tissue is a source of inflammatory mediators
Mazurek, T., Zhang, L., Zalewski, A., Mannion, J. D., Diehl, J. T., Arafat, H., Sarov-Blat, L., O’Brien, S., Keiper, E. A., Johnson, A. G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000099542.57313.c5 · Cited by 1,966
Epicardial adipose tissue: Anatomic, biomolecular and clinical relationships with the heart
Iacobellis, G., Corradi, D., & Sharma, A. M. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0319 · Cited by 1,015
Human epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 986
Iacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842
Chen, M., Chung, F., Chang, D., Tsai, J. C. ‐., Huang, H.-F., Shin, S., & Lee, Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1475 · Cited by 660
Self-citationTherapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
Matsuzawa, Y. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0380 · Cited by 434
Echocardiographic Epicardial Fat Thickness and Coronary Artery Disease
Jeong, J., Jeong, M. H., Yun, K. H., Oh, S. K., Park, E., Kim, Y. K., Rhee, S. J., Lee, E. M., Lee, J., Yoo, N. J., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.536 · Cited by 384
Production of Chemokines by Perivascular Adipose Tissue
Henrichot, E., Juge-Aubry, C. E., Pernin, A., Pache, J., Velebit, V., Dayer, J., Meda, P., Chizzolini, C., & Meier, C. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000188508.40052.35 · Cited by 383
Cheng, K.-H., Chu, C.-S., Lee, K.-T., Lin, T.-H., Hsieh, C.-C., Chiu, C.-C., Voon, W. ‐., Sheu, S. ‐., & Lai, W.-T. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803726 · Cited by 365
Self-citationRelationship of epicardial adipose tissue by echocardiography to coronary artery disease
Ahn, S. G., Lim, H., Joe, D.-Y., Kang, S.-J., Choi, B.-J., Choi, S.-Y., Yoon, M. H., Hwang, G., Tahk, S. J., & Shin, J.-H. (2007) · Heart · doi:10.1136/hrt.2007.118471 · Cited by 315
Screening for coronary artery disease in patients with diabetes
Bax, J. J., Young, L. H., Frye, R. L., Bonow, R. O., Steinberg, H. O., & Barrett, E. J. (2007) · Diabetes Care · doi:10.2337/dc07-9927 · Cited by 251
Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus
Scognamiglio, R., Negut, C., Ramondo, A., Tiengo, A., & Avogaro, A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.008 · Cited by 249
Marchington, J. M., & Pond, C. M. (1990) · PubMed · Cited by 239
Iacobellis, G., Leonetti, F., Singh, N., & M Sharma, A. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.04.016 · Cited by 224
de Vos, A. M., Prokop, M., Roos, C. J., Meijs, M. F. L., van der Schouw, Y. T., Rutten, A., Gorter, P. M., Cramer, M. J., Doevendans, P. A., Rensing, B. J. W. M., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm564 · Cited by 223
Formation of the epicardium studied with the scanning electron microscope
Ho, E., & Shimada, Y. (1978) · Developmental Biology · doi:10.1016/0012-1606(78)90263-4 · Cited by 220
Diabetes Mellitus and Macrovascular Disease: Mechanisms and Mediators
Boyle, P. J. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.07.003 · Cited by 153
Abbara, S., Desai, J. C., Cury, R. C., Butler, J., Nieman, K., & Reddy, V. Y. (2006) · European Journal of Radiology · doi:10.1016/j.ejrad.2005.12.030 · Cited by 153
Wheeler, G. L., Shi, R., Beck, S. R., Langefeld, C. D., Lenchik, L., Wagenknecht, L. E., Freedman, B. I., Rich, S. S., Bowden, D. W., Chen, M. Y., et al. (2005) · Investigative Radiology · doi:10.1097/00004424-200502000-00007 · Cited by 149
Arsenault, B. J. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.14.1518 · Cited by 144
Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy
Chung, F., Tsai, J. C. ‐., Chang, D., Shin, S., & Lee, Y. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1710 · Cited by 116
Self-citationThe Role of Periadventitial Fat in Atherosclerosis
Vela, D. C., Buja, L. M., Madjid, M., Burke, A., Naghavi, M., Willerson, J. T., Casscells, S. W., & Litovsky, S. H. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-481-tropfi · Cited by 93
Malavazos, A. E., Ermetici, F., Coman, C., Corsi, M. M., Morricone, L., & Ambrosi, B. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.08.061 · Cited by 86
BARBER, M. C., Ward, R. J., Richards, S. E., Salter, A. M., BUTTERY, P. J., Vernon, R. G., & Travers, M. T. (2000) · Journal of Animal Science · doi:10.2527/2000.78162x · Cited by 81
Sons, H. U., & Hoffmann (1986) · PubMed · Cited by 45
Insulin Resistance and Type 2 Diabetes - An Adipocentric View
Cederberg, A., & Enerbäck, S. (2003) · Current Molecular Medicine · doi:10.2174/1566524033361573 · Cited by 29
Wang, C.-P., Chung, F., Shin, S., & Lee, Y. (2007) · The Review of Diabetic Studies · doi:10.1900/rds.2007.4.77 · Cited by 15
Self-citationAlberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
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Echocardiographic epicardial fat: a review of research and clinical applications
Iacobellis, G., & Willens, H. J. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.10.013 · Cited by 700
Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.
Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., & Jazet, I. M. (2012) · International Journal of Endocrinology · doi:10.1155/2012/983814 · Cited by 368
Epicardial Fat: Definition, Measurements and Systematic Review of Main Outcomes
Bertaso, A., Graeff, D. B., Duncan, B. B., & Foppa, M. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130138 · Cited by 283
Perivascular adipose tissue as a cause of atherosclerosis
Verhagen, S. N., & Visseren, F. L. J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.034 · Cited by 266
Ouwens, D. M., Sell, H., Greulich, S., & Eckel, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01141.x · Cited by 238
Metadata
- Authors
- Wang, C., Hsu, H., Hung, W., Yu, T., Chen, Y., Chiu, C., Lu, L., Chung, F., Shin, S., & Lee, Y.
- Affiliations
- E-Da Hospital (TW)
- Cathay General Hospital (TW)
- Kaohsiung Medical University (TW)
- Corresponding author
- Lee, Yau‐Jiunn
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2009-05-13
- Volume
- 70
- Issue
- 6
- Pages
- 876-882
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2053427294
- Cited by
- 229
- References
- 31
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 15 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 18 · 2013: 24 · 2012: 19
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial adipose tissue, type 2 diabetes, metabolic syndrome, coronary artery disease, EAT volume, coronary artery calcium score, Gensini score, visceral fat, adipokines, coronary artery lesions
- MeSH terms
- Adipose Tissue, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Pericardium, Severity of Illness Index, Tomography, X-Ray Computed, Case-Control Studies, Metabolic Syndrome
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