Cited by 229Cardiovascular Disease and AdiposityCardiac Imaging and DiagnosticsAdipokines, Inflammation, and Metabolic Diseases

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Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis

Wang, Chao‐Ping, Hsu, Hui‐Ling, Hung, Wei‐Chin, Yu, Teng‐Hung, Chen, Yen‐Hsun, Chiu, Cheng‐An, Lu, Li‐Fen, Chung, Fu‐Mei, Shin, Shyi‐Jang, Lee, Yau‐Jiunn·2009·Clinical Endocrinology

DOI 10.1111/j.1365-2265.2008.03411.x

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Abstract

OBJECTIVE: Epicardial adipose tissue (EAT) is a part of visceral fat deposited around the heart between the pericardium and myocardium along the distribution of coronary arteries. EAT thickness is reported to be associated with coronary atherosclerosis; however, no study has measured EAT volume in patients with type 2 diabetes or investigate its association with coronary artery disease. DESIGN: A hospital-based case control study. PATIENTS: A total of 49 patients with type 2 diabetes mellitus (T2DM) and 78 nondiabetic controls were studied. MEASUREMENTS: Cardiac multislice computed tomography was used to measure EAT volume, Gensini score, coronary artery calcium score and, coronary lesions. The relationships between EAT volume, markers of coronary atherosclerosis and anthropometric and biochemical parameters of metabolic syndrome (MetS) were investigated. RESULTS: EAT volume was significantly higher in patients with T2DM than in nondiabetic subjects (166.1 +/- 60.6 cm(3) vs. 123.4 +/- 41.8 cm(3), P < 0.0001). Logistic regression analysis revealed independent and significant associations between EAT and diabetic status. EAT volume was significantly associated with components of MetS (BMI, waist circumference, fasting serum glucose, total cholesterol, HDL-cholesterol, and triglycerides levels), Gensini score, coronary lesions, coronary disease and coronary calcium scores. Univariate, multivariate and trend analyses confirmed that EAT volume was associated with MetS component clustering and the coronary atherosclerosis index. CONCLUSIONS: The analytical results indicate that EAT volume is increased in T2DM patients and is associated with unfavourable components of MetS and coronary atherosclerosis. The close anatomical relationship between EAT and the coronary arteries, combined with other evidence indicating that EAT is a biologically active adipokine-secreting tissue, suggest that EAT participates in the pathogenesis of diabetic coronary atherosclerosis.

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Authors: Wang, C., Hsu, H., Hung, W., Yu, T., Chen, Y., Chiu, C., Lu, L., Chung, F., Shin, S., & Lee, Y.
Affiliations: E-Da Hospital (TW)
Cathay General Hospital (TW)
Kaohsiung Medical University (TW)
Corresponding author: Lee, Yau‐Jiunn
ORCID: Wang, Chao‐Ping
Hung, Wei‐Chin
Yu, Teng‐Hung
Chung, Fu‐Mei
Shin, Shyi‐Jang
Lee, Yau‐Jiunn
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2009-05-13
Volume: 70
Issue: 6
Pages: 876-882
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/j.1365-2265.2008.03411.x
OpenAlex: W2053427294
Cited by: 229
References: 31
Citations by year: 2026: 7 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 15 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 18 · 2013: 24 · 2012: 19
FWCI: 8.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: epicardial adipose tissue, type 2 diabetes, metabolic syndrome, coronary artery disease, EAT volume, coronary artery calcium score, Gensini score, visceral fat, adipokines, coronary artery lesions
MeSH terms: Adipose Tissue, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Pericardium, Severity of Illness Index, Tomography, X-Ray Computed, Case-Control Studies, Metabolic Syndrome

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Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis

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