Cited by 78Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesGenetic and Kidney Cyst Diseases

Plasma monocyte chemoattractant protein‐1 (MCP‐1) and macrophage inflammatory protein‐1α are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment

Glintborg, Dorte, Andersen, Marianne, Richelsen, Bjørn, Bruun, Jens M.·2009·Clinical Endocrinology

Abstract

OBJECTIVE: Hirsutism is most often caused by polycystic ovary syndrome (PCOS). PCOS patients are characterized by insulin resistance, abdominal obesity and low-grade inflammation. Insulin sensitizing treatment reduces the inflammatory state, but the effect on serum levels of migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha have not been evaluated before in PCOS. RESEARCH DESIGN AND METHODS: Plasma chemokine levels (MCP-1, MIP-1alpha and MIF) were measured in two study designs. (i) 51 hirsute patients and 63 matched controls and (ii) 30 PCOS patients before and after randomized treatment with 30 mg pioglitazone/placebo for 16 weeks. Clinical evaluations and whole body DXA-scans were performed in all participants. RESULTS: Hirsute patients (n = 51) had significantly increased MCP-1 [121 (15-950) vs. 81 (18-365) pg/ml; P < 0.05] and MIP-1alpha[179 (8-4202) vs. 103 (4-1598) pg/ml; P < 0.05] than controls of matched body composition [geometric mean (-2SD to +2SD)]. In PCOS (n = 30), MCP-1, MIP-1alpha and MIF correlated positively with central fat mass. A BMI independent positive association was found between MIF and free testosterone (r = 0.49, P = 0.01) in PCOS. Pioglitazone treatment significantly improved insulin sensitivity without affecting testosterone, body composition, MCP-1, MIP-1alpha and MIF levels. CONCLUSIONS: Chemokine levels were significantly increased and showed close associations with measures of adiposity in PCOS patients, but were unchanged during insulin sensitizing treatment with pioglitazone. Our data suggests a fat mass independent association between testosterone and MIF levels in PCOS and the effect of anti-androgen treatment on chemokine levels needs to be examined.

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Crossref · 10.1111/j.1365-2265.2009.03523.x

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Authors
Glintborg, D., Andersen, M., Richelsen, B., & Bruun, J. M.
Affiliations
  • Odense University Hospital (DK)
  • Aarhus University Hospital (DK)
Corresponding author
Glintborg, Dorte
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2009-10-05
Volume
71
Issue
5
Pages
652-658
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
OpenAlex
W2049363219
Cited by
78
References
50
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 11 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 3
FWCI
6.28
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, MCP-1, macrophage inflammatory protein-1alpha, chemokines, adiposity, pioglitazone, insulin resistance, hirsutism, free testosterone, low-grade inflammation
MeSH terms
Pioglitazone, Cholesterol, Female, Humans, Hypoglycemic Agents, Lipoproteins, HDL, Macrophage Migration-Inhibitory Factors, Polycystic Ovary Syndrome, Radioimmunoassay, Testosterone, Triglycerides, Chemokine CCL2, Intramolecular Oxidoreductases, Thiazolidinediones, Adiposity, Chemokine CCL3

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