Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke
Abstract
An increase in cerebrospinal fluid (CSF)-total-tau, and recently also in CSF-phospho-tau, has been found in Alzheimer's disease (AD). However, the mechanisms for these changes are not known. We examined longitudinal CSF samples from nine patients with acute stroke. As compared with baseline levels (day 0-1), CSF-total-tau showed an increase at day 2-3 (179%; P=0.018), day 7-9 (257%; P=0.003), and after 3 weeks (425%; P=0.002) and returned to normal levels after 3-5 months (140%; NS). In contrast, there was no significant change in CSF-phospho-tau. These findings suggest that total tau and phospho-tau in CSF reflect different pathogenic processes in the brain; total-tau the degree of neuronal damage and phospho-tau the phosphorylation state of tau and thus possibly the formation of neurofibrillary tangles.
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There is a marked temporary increase in T-tau, with no change in P-tau, in traumatic brain injury and stroke that correlates with the severity of neuronal damage.
“There is a marked temporary increase in T-tau, with no change in P-tau, in traumatic brain injury and stroke that correlates with the severity of neuronal damage [146,147].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [146]
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- Authors
- Hesse, C., Rosengren, L., Andreasen, N., Davidsson, P., Vanderstichele, H., Vanmechelen, E., & Blennow, K.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Fujirebio (Belgium) (BE)
- Corresponding author
- Blennow, Kaj
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 297
- Issue
- 3
- Pages
- 187-190
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2049943618
- Cited by
- 450
- References
- 1
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 23 · 2021: 20 · 2020: 37 · 2019: 27 · 2018: 27 · 2017: 18 · 2016: 23 · 2015: 18 · 2014: 18 · 2013: 23 · 2012: 28
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- total tau, phosphorylated tau, cerebrospinal fluid biomarkers, acute stroke, tau phosphorylation, neurofibrillary tangles, neuronal injury, Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Longitudinal Studies, Male, Phosphorylation, Predictive Value of Tests, Biomarkers, tau Proteins, Disease Progression, Stroke
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