Cited by 2,955Birth, Development, and HealthPrenatal Substance Exposure EffectsPregnancy and preeclampsia studies

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The origins of the developmental origins theory

Barker, D. J. P.·2007·Journal of Internal Medicine

DOI 10.1111/j.1365-2796.2007.01809.x

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Abstract

Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, function and metabolism in ways that lead to coronary heart disease in later life. The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward.

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Authors: Barker, D. J. P.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Barker, D. J. P.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 2007-04-10
Volume: 261
Issue: 5
Pages: 412-417
ISSN: 0954-6820 (ISSN-L)
1365-2796
DOI: 10.1111/j.1365-2796.2007.01809.x
OpenAlex: W2143847855
Cited by: 2,955
References: 39
Citations by year: 2026: 174 · 2025: 216 · 2024: 219 · 2023: 263 · 2022: 258 · 2021: 247 · 2020: 209 · 2019: 165 · 2018: 170 · 2017: 160 · 2016: 135 · 2015: 123 · 2014: 103 · 2013: 99 · 2012: 115
FWCI: 10.12
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: coronary artery disease, developmental origins of health and disease, low birth weight, intrauterine undernutrition, fetal origins of disease, coronary heart disease prevention
MeSH terms: Adult, Coronary Disease, England, Female, Humans, Infant Mortality, Infant, Low Birth Weight, Infant, Newborn, Life Style, Male, Pregnancy, Prenatal Exposure Delayed Effects, Social Conditions, Wales, Fetal Development, Fetal Nutrition Disorders

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