The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The origins of the developmental origins theory
Abstract
Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, function and metabolism in ways that lead to coronary heart disease in later life. The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward.
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“Together, epigenetics—the study of gene–environment interaction and regulation—and DOHaD—the study of how early adverse exposure can impact health across the life course—provide a biosocial framework for understanding how behaviors during pregnancy can impact fetal and infant development (Landecker and Panofsky 2013; Barker 2007).”
From The Politics of Postgenomic Reproduction: Exploring Pregnant Narratives from within a Clinical Trial (2022) · cites this paper as Barker 2007
In the citing paper
“In nutritional and environmental epigenetics and DOHaD research, there is a dearth of information on people's experiences with eating and weight management during pregnancy.2”
From The Politics of Postgenomic Reproduction: Exploring Pregnant Narratives from within a Clinical Trial (2022) · cites this paper as [2]
In the citing paper
“Barker’s foundational work identified associations between undernutrition during gestation, low birth weight and higher rates of ischemic heart and coronary artery disease mortality in adulthood in British children born in the 1920s [38,39,40,41].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [39]
Citations
Cites
Sick individuals and sick populations
Rose, G. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.3.427 · Cited by 3,736
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Self-citationFetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Self-citationINFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
BARKER, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91340-1 · Cited by 2,892
Self-citationSick individuals and sick populations
ROSE, G. (1985) · International Journal of Epidemiology · doi:10.1093/ije/14.1.32 · Cited by 2,701
Phenotypic Plasticity and the Origins of Diversity
West-Eberhard, M. J. (1989) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.20.110189.001341 · Cited by 2,110
Trajectories of growth among children who have coronary events as adults
Barker, D. J. P., Osmond, C., Forsén, T. J., Kajantie, E., & Eriksson, J. G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044160 · Cited by 1,517
Self-citationINEQUALITIES IN DEATH—SPECIFIC EXPLANATIONS OF A GENERAL PATTERN?
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Cited by
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Items 1,001–1,006 of 1,006
Kaspi, A., Khurana, I., Ziemann, M., Connor, T., Spolding, B., Zimmet, P., Walder, K., & El‐Osta, A. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800134 · Cited by 19
Pantaleão, L. C., Inzani, I., Furse, S., Loche, E., Hufnagel, A., Ashmore, T., Blackmore, H. L., Jenkins, B., Carpenter, A. A. M., Wilczynska, A., et al. (2022) · eLife · doi:10.7554/elife.69078 · Cited by 19
Durkin, A. M., Zou, R., Boucher, J. M., Boyles, M. S., van Boxel, J., Bustamante, M., Christopher, E. A., Dadvand, P., Dusza, H. M., van Duursen, M., et al. (2024) · doi:10.2196/preprints.63176 · Cited by 18
Durkin, A. M., Zou, R., Boucher, J. M., Boyles, M. S., van Boxel, J., Bustamante, M., Christopher, E. A., Dadvand, P., Dusza, H. M., van Duursen, M., et al. (2024) · JMIR Research Protocols · doi:10.2196/63176 · Cited by 18
“Disruption by environmental toxicants during this window of heightened susceptibility can have a long-lasting impact on the molecular and physiological phenotype and health later in life [25].”
BackgroundThe Politics of Postgenomic Reproduction: Exploring Pregnant Narratives from within a Clinical Trial
Valdez, N. (2022) · Science, Technology, & Human Values · doi:10.1177/01622439211066759 · Cited by 4
Unpacking developmental programming: a conceptual and historical analysis in the context of DOHaD
Gretchev, A., Temples, H. S., England-Mason, G., Dewey, D., Sarasua, S. M., Farrell, C., & Haley-Zitlin, V. (2026) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174426100518 · Cited by 4
“The authors replicated Barker ’ s finding that the relationship between infant mortality rates and ischemic heart disease persisted after accounting for geographic variation, supporting the robustness of this relationship.”
Influential
Metadata
- Authors
- Barker, D. J. P.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Barker, D. J. P.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-04-10
- Volume
- 261
- Issue
- 5
- Pages
- 412-417
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2143847855
- Cited by
- 2,955
- References
- 39
- Citations by year
- 2026: 174 · 2025: 216 · 2024: 219 · 2023: 263 · 2022: 258 · 2021: 247 · 2020: 209 · 2019: 165 · 2018: 170 · 2017: 160 · 2016: 135 · 2015: 123 · 2014: 103 · 2013: 99 · 2012: 115
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- coronary artery disease, developmental origins of health and disease, low birth weight, intrauterine undernutrition, fetal origins of disease, coronary heart disease prevention
- MeSH terms
- Adult, Coronary Disease, England, Female, Humans, Infant Mortality, Infant, Low Birth Weight, Infant, Newborn, Life Style, Male, Pregnancy, Prenatal Exposure Delayed Effects, Social Conditions, Wales, Fetal Development, Fetal Nutrition Disorders
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