Dietary intake of fat and fibre according to reference values relates to higher gut microbiota richness in overweight pregnant women
Open accessAbstract
The diet-microbiota-metabolism relationships during pregnancy are mostly unknown. We explored the effect of the habitual diet and adherence to the dietary reference values on gut microbiota composition and diversity. Further, the association of gut microbiota with serum lipidomics and low-grade inflammation was evaluated. Overweight and obese women (BMI 30·7 (sd 4·4) kg/m2, n 100) were studied at early pregnancy (≤17 weeks). Intakes of nutrients were calculated from 3-d food diaries. Faecal microbiota composition was analysed using 16S rRNA gene sequencing. Fasting serum lipidomic profiles were determined by NMR. High-sensitivity C-reactive protein, glycoprotein acetylation (GlycA) and lipopolysaccharide activity were used as markers for low-grade inflammation. The recommended dietary intake of fibre and fat was related to higher gut microbiota richness and lower abundance of Bacteroidaceae. Correlations were observed between gut microbiota richness and GlycA and between a few microbiota genera and serum lipoprotein particles. As a conclusion, adherence to the dietary reference intake of fat and fibre was associated with beneficial gut microbiota composition, which again contributed to lipidomic profile. Higher gut microbiota richness and nutrient intakes were linked to a lower level of low-grade inflammation marker GlycA. This finding offers novel insights and opportunities for dietary modification during pregnancy with potential of improving the health of the mother and the child.
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High SFA intake is associated with reduction in total bacterial abundance in humans and in microbial diversity and richness, as well as an increase in proinflammatory bacteria (e.g., Bilophila wadsworthia) in mice.
“For example, high SFA intake has been shown to be associated with reduction in total bacterial abundance in humans (95) and in microbial diversity and richness (95,96), as well as an increase in proinflammatory bacteria (e.g., Bilophila wadsworthia) (96)(97)(98) in mice.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [95]
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- Authors
- Röytiö, H., Mokkala, K., Vahlberg, T., & Laitinen, K.
- Affiliations
- University of Turku (FI)
- Corresponding author
- Laitinen, Kirsi
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-09-13
- Volume
- 118
- Issue
- 5
- Pages
- 343-352
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2754154071
- Cited by
- 128
- References
- 42
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 19 · 2020: 19 · 2019: 13 · 2018: 12 · 2017: 2
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-09-13)
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Kulttuurirahasto
- Juho Vainion Säätiö
- Päivikki ja Sakari Sohlbergin Säätiö
- Turun Yliopistollinen Keskussairaala
- Varsinais-Suomen Rahasto
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, dietary fat intake, dietary fiber intake, dietary reference values, overweight in pregnancy, maternal obesity, microbiome diversity, Bacteroidaceae, serum lipidomics, lipoprotein particles, low-grade inflammation, C-reactive protein, early pregnancy, maternal nutrition
- MeSH terms
- Gastrointestinal Microbiome, Adult, C-Reactive Protein, Cholesterol, Diet, Dietary Fats, Dietary Fiber, Feces, Female, Glycoproteins, Humans, Inflammation, Obesity, Patient Compliance, Pregnancy, Reference Values, Triglycerides, Biomarkers, Diet Records, Body Mass Index, Randomized Controlled Trials as Topic, Overweight
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