Cited by 237Dementia and Cognitive Impairment ResearchAdipokines, Inflammation, and Metabolic DiseasesNutrition and Health in Aging

Adiposity indices and dementia

Gustafson, Deborah·2006·The Lancet Neurology

Abstract

Indicators of adiposity, such as body-mass index (BMI), may be markers for changes in energy metabolism that influence dementia risk, progression, and ultimately death. Cross-sectional studies show that people with dementia have a lower BMI than those without dementia, which is potentially due to a greater rate of BMI decline occurring during the years immediately preceding dementia onset. However, a high BMI can also increase the risk for dementia when measured before clinical dementia onset, which might be due to vascular disorders or bioactive hormonal compounds that are secreted by adipose tissue. In this personal view, I consider how dementia is associated with BMI by looking at the role of BMI and obesity syndromes, mechanisms associated with adiposity, and the potential for hypothalamic dysregulation during the life course. Understanding the life course of adiposity by use of common surrogate measures, such as BMI, among those who do and do not develop dementia is relevant for understanding the causes of dementia and for shaping possible treatment options.

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Crossref · 10.1016/s1474-4422(06)70526-9

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82 of 82 references verified0 citation errors · 0 not checkable

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  • The point in the life course at which a dementia risk factor is measured affects whether and how its association is observed.

    “Thus, when in the life course a risk factor for dementia is measured determines if and how the association is characterized 12, 13.”

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Authors
Gustafson, D.
Affiliations
Medical College of Wisconsin (US)
Corresponding author
Gustafson, Deborah
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2006-08
Volume
5
Issue
8
Pages
713-720
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2101922440
Cited by
237
References
82
Citations by year
2026: 5 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 14 · 2015: 8 · 2014: 20 · 2013: 15 · 2012: 20
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Swedish Brain Power
  • National Institutes of Health (5r03ag026098-02)
  • National Institute on Aging (1R03AG026098-01A1)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
adiposity, dementia, body mass index, obesity, energy metabolism, adipose tissue hormones, vascular risk, life course, dementia risk
MeSH terms
Age Factors, Dementia, Humans, Hypothalamus, Obesity, Risk, Body Mass Index, Adiposity

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