Adiposity indices and dementia
Abstract
Indicators of adiposity, such as body-mass index (BMI), may be markers for changes in energy metabolism that influence dementia risk, progression, and ultimately death. Cross-sectional studies show that people with dementia have a lower BMI than those without dementia, which is potentially due to a greater rate of BMI decline occurring during the years immediately preceding dementia onset. However, a high BMI can also increase the risk for dementia when measured before clinical dementia onset, which might be due to vascular disorders or bioactive hormonal compounds that are secreted by adipose tissue. In this personal view, I consider how dementia is associated with BMI by looking at the role of BMI and obesity syndromes, mechanisms associated with adiposity, and the potential for hypothalamic dysregulation during the life course. Understanding the life course of adiposity by use of common surrogate measures, such as BMI, among those who do and do not develop dementia is relevant for understanding the causes of dementia and for shaping possible treatment options.
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The point in the life course at which a dementia risk factor is measured affects whether and how its association is observed.
“Thus, when in the life course a risk factor for dementia is measured determines if and how the association is characterized 12, 13.”
From Overweight in midlife and risk of dementia: a 40-year follow-up study (2009) · cites this paper as [12]
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- Authors
- Gustafson, D.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Gustafson, Deborah
- ORCID
- Gustafson, Deborah
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 5
- Issue
- 8
- Pages
- 713-720
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2101922440
- Cited by
- 237
- References
- 82
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- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Brain Power
- National Institutes of Health (5r03ag026098-02)
- National Institute on Aging (1R03AG026098-01A1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- adiposity, dementia, body mass index, obesity, energy metabolism, adipose tissue hormones, vascular risk, life course, dementia risk
- MeSH terms
- Age Factors, Dementia, Humans, Hypothalamus, Obesity, Risk, Body Mass Index, Adiposity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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