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Cited by 40Effects and risks of endocrine disrupting chemicalsNeuroendocrine regulation and behaviorSexual Differentiation and Disorders

Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole

Engell, Miles Dean, Godwin, John, Young, Larry J., Vandenbergh, John G.·2006·Neurotoxicology and Teratology
DOI 10.1016/j.ntt.2005.10.002
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Abstract

Endocrine-disrupting chemicals (EDCs) are synthetic chemicals that arise from sources such as pesticides and have the ability to mimic or inhibit gonadal steroid hormones. The objective of this research was to examine the effects of EDCs on the behaviors associated with monogamy and the expression of related neuropeptide receptors. Pine voles, a novel experimental mammal, were chosen because they display strong monogamous pair bonding. Female pine voles were orally administered estrogenic diethylstilbestrol (DES) and methoxychlor (MXC) or oil control throughout gestation and lactation of pups. Exposed pups were tested as adults. Preference for the mate and maternal behaviors were assessed. While the ability to form partner preferences was intact, DES-exposed females showed increased aggression toward a stranger, while MXC exposed females showed a strong trend toward spending more time alone. Oxytocin (OT) receptor binding in the brain was assessed for possible effects on this behaviorally important neuropeptide signaling system. The cingulate cortex showed a reduction in OT binding in the MXC group. These findings demonstrate that exposure to EDCs during pre- and neonatal development can alter female adult neural phenotype and behavior related to monogamous behavior traits.

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  • In the socially monogamous pine vole, perinatal oral exposure to approximately 2,000 μg/kg bw methoxychlor produced some offspring effects, but only in females.

    “In the socially monogamous pine vole, perinatal oral exposure to approximately 2,000 µg/kg bw methoxychlor produced some offspring effects, but only in females (75).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [75]

  • OTR binding was unchanged in LS but reduced in the cingulate of methoxychlor-exposed females compared to unexposed controls.

    “OTR binding was unchanged in LS but reduced in the cingulate of the exposed females compared to unexposed controls.”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [75]

Cites

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Research works printed but not linked: 2

  1. Gray, 1992, Chemical induced alterations of sexual differentiation: a review of effects in humans and rodents, 203
  2. Wolf, 2000, Effects of prenatal testosterone propionate on the sexual development of male and female rats, Biol. Reprod., 62, 247

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Authors
Engell, M. D., Godwin, J., Young, L. J., & Vandenbergh, J. G.
Affiliations
  • North Carolina State University (US)
  • Emory University (US)
Corresponding author
Vandenbergh, John G.
ORCID
Godwin, John
Venue
Neurotoxicology and Teratology
Publisher
Elsevier BV
Published
2006-01
Volume
28
Issue
1
Pages
103-110
ISSN
0892-0362 (ISSN-L)
DOI
10.1016/j.ntt.2005.10.002
OpenAlex
W2147376662
Semantic Scholar
15f987967046b24d29e6563f272ae00333ecc36d
Cited by
40
References
76
Citations by year
2025: 2 · 2024: 2 · 2021: 2 · 2020: 1 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurotoxicology and Teratology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
endocrine disruptors, perinatal exposure, diethylstilbestrol, methoxychlor, pine vole, monogamy, pair bonding, maternal behavior, aggression, oxytocin receptor, cingulate cortex, neuropeptide signaling, female behavior, neurobehavioral development
MeSH terms
Aggression, Animals, Animals, Newborn, Behavior, Animal, Binding, Competitive, Brain, Arvicolinae, Diethylstilbestrol, Disease Models, Animal, Female, Gyrus Cinguli, Methoxychlor, Pair Bond, Pregnancy, Prenatal Exposure Delayed Effects, Social Behavior, Receptors, Oxytocin, Estradiol Congeners

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