A review of applications of tea tree oil in dermatology

Pazyar, Nader; Yaghoobi, Reza; Bagherani, Nooshin; Kazerouni, Afshin

doi:10.1111/j.1365-4632.2012.05654.x

Cited by 252Essential Oils and Antimicrobial ActivityAcne and Rosacea Treatments and EffectsMedicinal Plant Research

A review of applications of tea tree oil in dermatology

Pazyar, Nader, Yaghoobi, Reza, Bagherani, Nooshin, Kazerouni, Afshin·2013·International Journal of Dermatology

DOI 10.1111/j.1365-4632.2012.05654.x

Open this paper in CoChat — free account

Abstract

Tea tree oil (TTO) is an essential oil, steam‐distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen‐4‐ol and a maximum content of 1, 8‐cineole. Terpinen‐4‐ol is a major TTO component which exhibits strong antimicrobial and anti‐inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad‐spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa. Several studies have suggested the uses of TTO for the treatment of acne vulgaris, seborrheic dermatitis, and chronic gingivitis. It also accelerates the wound healing process and exhibits anti‐skin cancer activity. This review opens up new horizons for dermatologists in the use of this herbal agent.

Integrity signals

Registry

Crossref · 10.1111/j.1365-4632.2012.05654.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Alternative therapies such as tea tree oil have been reported for SD and dandruff.
“Alternative therapies have been reported as well, such as tea tree oil [40,41].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [40]
Pazyar et al. review on tea tree oil in dermatology was classified as Level IV evidence and most cited studies were small-scale or not replicated.
“According to the Oxford evidence hierarchy, this would fall under the category of Level IV evidence. Additionally, the paper could benefit from a more critical analysis of the potential risks and side effects associated with the use of tea tree oil in dermatology.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [14]

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374 · see citing works
Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
Carson, C. F., Hammer, K. A., & Riley, T. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.50-62.2006 · Cited by 1,429 · see citing works
A review of the toxicity of Melaleuca alternifolia (tea tree) oil
Hammer, K. A., Carson, C. F., Riley, T. V., et al. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.09.001 · Cited by 313 · see citing works
A comparative study of tea‐tree oil versus benzoylperoxide in the treatment of acne
Bassett, I. B., Barnetson, R. S. C., & Pannowitz, D. L. (1990) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1990.tb126150.x · Cited by 286 · see citing works
Inhibition of Oxidation of Human Low-Density Lipoproteins by Phenolic Substances in Different Essential Oils Varieties
Teissèdre, P., & Waterhouse, A. L. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990921x · Cited by 249 · see citing works
Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture.
Schnitzler, P., Schön, K., & Reichling, J. (2001) · PubMed · Cited by 233 · see citing works
Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials
Martin, K. W. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg087 · Cited by 226 · see citing works
In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp.
Hammer, K., Carson, C., & Riley, T. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.5.591 · Cited by 223 · see citing works
In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species
Mondello, F., Bernardis, F. D., Girolamo, A., et al. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-158 · Cited by 222 · see citing works
In vitro and in vivo killing of ocular Demodex by tea tree oil
Gao, Y.-Y. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.072363 · Cited by 212 · see citing works
Evaluation of Antioxidant Activity of Australian Tea Tree (Melaleuca alternifolia) Oil and Its Components
Kim, H., Chen, F., Wu, C., Wang, X., Chung, H. Y., & Jin, Z. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035377d · Cited by 206 · see citing works
Clinical Treatment of Ocular Demodecosis by Lid Scrub With Tea Tree Oil
Gao, Y., Pascuale, M. A. D., Elizondo, A., et al. (2007) · Cornea · doi:10.1097/01.ico.0000244870.62384.79 · Cited by 203 · see citing works
Tea tree oil reduces histamine-induced skin inflammation
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05034.x · Cited by 185 · see citing works
Adverse and beneficial effects of plant extracts on skin and skin disorders.
Mantle, D., Gok, M. A., & Lennard, T. W. J. (2001) · PubMed · Cited by 180 · see citing works
Acaricidal Activity of Melaleuca alternifolia (Tea Tree) Oil
Walton, S. F., McKinnon, M., Pizzutto, S. J., Dougall, A. M., Williams, E., & Currie, B. J. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.5.563 · Cited by 178 · see citing works
The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: A randomized, double-blind placebo-controlled study
Jooya, A., Siadat, A., Iraji, F., & Enshaieh, S. (2007) · Indian Journal of Dermatology, Venereology and Leprology · doi:10.4103/0378-6323.30646 · Cited by 165 · see citing works
Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis
Walton, S. F., Myerscough, M. R., & Currie, B. J. (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90454-1 · Cited by 162 · see citing works
Cooling the burn wound: evaluation of different modalites
Jandera, V., Hudson, D. A., Wet, P. M. D., et al. (2000) · Burns · doi:10.1016/s0305-4179(99)00133-3 · Cited by 157 · see citing works
In vitro Effect of Essential Oils and Isolated Mono- and Sesquiterpenes on Leishmania major and Trypanosoma brucei
Mikus, J., Harkenthal, M., Steverding, D., et al. (2000) · Planta Medica · doi:10.1055/s-2000-8548 · Cited by 154 · see citing works
Treatment of dandruff with 5% tea tree oil shampoo
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.122734 · Cited by 152 · see citing works
Inhibition of acetylcholinesterase by Tea Tree oil
Mills, C., Cleary, B., Walsh, J. J., & Gilmer, J. F. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022773 · Cited by 151 · see citing works
Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree) oil and clotrimazole
Buck, D. S., Nidorf, D. M., & Addino, J. G. (1998) · Complementary Therapies in Medicine · doi:10.1016/s0965-2299(98)80022-8 · Cited by 138 · see citing works
Natural variation in the essential oil content of Melaleuca alternifolia Cheel (Myrtaceae)
Homer, L. E., Leach, D. N., Lea, D., et al. (2000) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(99)00071-x · Cited by 138 · see citing works
Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis
Carson, C. F. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.3.450 · Cited by 127 · see citing works
The effects of a tea tree oil-containing gel on plaque and chronic gingivitis.
Soukoulis, S., & Hirsch, R. S. (2004) · Australian dental journal · doi:10.1111/j.1834-7819.2004.tb00054.x · Cited by 120 · see citing works
Role of Antifungal Agents in the Treatment of Seborrheic Dermatitis
Gupta, A. K., Nicol, K., & Batra, R. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405060-00006 · Cited by 109 · see citing works
Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells
Loughlin, R. G., Gilmore, B., McCarron, P. A., & Tunney, M. M. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02334.x · Cited by 108 · see citing works
Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream
Syed, T. A., Qureshi, Z. A., Ali, S. M., Ahmad, S., & Ahmad, S. (1999) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1999.00396.x · Cited by 105 · see citing works
Role of the MexAB-OprM Efflux Pump of Pseudomonas aeruginosa in Tolerance to Tea Tree ( Melaleuca alternifolia ) Oil and Its Monoterpene Components Terpinen-4-ol, 1,8-Cineole, and α-Terpineol
Papadopoulos, C. J., Carson, C. F., Chang, B. J., et al. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02334-07 · Cited by 101 · see citing works
Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: A randomized, placebo‐controlled, blinded study
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002) · Australasian Journal of Dermatology · doi:10.1046/j.1440-0960.2002.00590.x · Cited by 81 · see citing works
Tea tree oil reduces histamine-induced oedema in murine ears
Brand, C., Townley, S. L., Finlay‐Jones, J. J., & Hart, P. H. (2002) · Inflammation Research · doi:10.1007/pl00000305 · Cited by 77 · see citing works
The influence of essential oils on the process of wound healing: a review of the current evidence
Woollard, A., Tatham, K. C., & Barker, S. (2007) · Journal of Wound Care · doi:10.12968/jowc.2007.16.6.27064 · Cited by 71 · see citing works
A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a "suffocation" product
Barker, S. C., & Altman, P. M. (2010) · BMC Dermatology · doi:10.1186/1471-5945-10-6 · Cited by 63 · see citing works
Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling
Henley, D. V., & Korach, K. S. (2010) · HORMONES · doi:10.14310/horm.2002.1270 · Cited by 62 · see citing works
Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies
Khalil, Z. G., Pearce, A., Satkunanathan, N., Storer, E., Finlay‐Jones, J. J., & Hart, P. H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23407.x · Cited by 61 · see citing works
Tea Tree Oil: Cutaneous Effects of the Extracted Oil of Melaleuca alternifolia
Crawford, G. H., Sciacca, J. R., & James, W. D. (2004) · Dermatitis · doi:10.2310/6620.2004.04003 · Cited by 59 · see citing works
Interaction of Tea Tree Oil with Model and Cellular Membranes
Giordani, C., Molinari, A., Toccacieli, L., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060228i · Cited by 46 · see citing works
Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms
Kunicka‐Styczyńska, A., Sikora, M., & Kalemba, D. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00582.x · Cited by 46 · see citing works
Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil
Greay, S. J., Ireland, D. J., Kissick, H. T., et al. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1267-3 · Cited by 45 · see citing works
Tea Tree Oil Might Combat Melanoma
Bozzuto, G., Colone, M., Toccacieli, L., et al. (2010) · Planta Medica · doi:10.1055/s-0030-1250055 · Cited by 39 · see citing works
In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin
van de Sande, W. W. J., Fahal, A. H., Riley, T. V., Verbrugh, H. A., & van Belkum, A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl526 · Cited by 33 · see citing works
Essential Oils for Management of Symptoms in Critically Ill Patients
Halm, M. A. (2008) · American Journal of Critical Care · doi:10.4037/ajcc2008.17.2.160 · Cited by 28 · see citing works
[Effect of mouthwashing with tea tree oil on plaque and inflammation].
Saxer, U. P., Stäuble, A., Szabó, S., et al. (2003) · PubMed · Cited by 26 · see citing works
Successful topical treatment of hand warts in a paediatric patient with tea tree oil (Melaleuca alternifolia)
Millar, B. C., & Moore, J. E. (2008) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2008.05.003 · Cited by 25 · see citing works
Tea Tree Oil as a Novel Antipsoriasis Weapon
Pazyar, N., & Yaghoobi, R. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000337936 · Cited by 23 · see citing works
Self-citation
A randomized controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol
Thompson, G., Blackwood, B., McMullan, R., et al. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-161 · Cited by 21 · see citing works
Medicated shampoos for the treatment of seborrheic dermatitis.
Waldroup, W., & Scheinfeld, N. S. (2008) · PubMed · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

Essential oils used in aromatherapy: A systemic review
Ali, B., Al‐Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., & Anwar, F. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2015.05.007 · Cited by 1,184 · see citing works
“Cold, fever, flu and chickenpox have called for its use [71,72].”
Background
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 527 · see citing works
“The essential oil from Melaleuca alternifolia also shows antioxidant activities potentially useful in dermatitis and skin cancers [160].”
Background
Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process
Michalak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020585 · Cited by 460 · see citing works
Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398 · see citing works
“Alternative therapies have been reported as well, such as tea tree oil [40,41].”
Skin Wound Healing and Phytomedicine: A Review
Pazyar, N., Yaghoobi, R., Rafiee, E., Mehrabian, A., & Feily, A. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000357477 · Cited by 278 · see citing works
Self-citation
Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases
Orchard, A., & van Vuuren, S. F. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/4517971 · Cited by 273 · see citing works
“alternifolia (terpinen-4-ol) has the ability to hinder tumour necrosis factor (TNF), interleukin1, interleukin-8, and interleukin-10, and prostaglandin E2 [300].”
Background
Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement
Sharma, M., Grewal, K., Jandrotia, R., Batish, D. R., Singh, H. P., & Kohli, R. K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112514 · Cited by 187 · see citing works
Tea tree oil: contact allergy and chemical composition
de Groot, A. C., & Schmidt, E. (2016) · Contact Dermatitis · doi:10.1111/cod.12591 · Cited by 180 · see citing works
Treatment of seborrheic dermatitis: a comprehensive review
Borda, L. J., Perper, M., & Keri, J. E. (2018) · Journal of Dermatological Treatment · doi:10.1080/09546634.2018.1473554 · Cited by 169 · see citing works
“TTO is an essential oil obtained from the leaves of Melaleuca alternifolia in Australia (90).”
Background
Tea tree oil: a promising essential oil
Yadav, E., Kumar, S., Mahant, S., Khatkar, S., & Rao, R. (2016) · Journal of Essential Oil Research · doi:10.1080/10412905.2016.1232665 · Cited by 119 · see citing works
In vitro and in vivo evaluation of gellan gum hydrogel films: Assessing the co impact of therapeutic oils and ofloxacin on wound healing
Mahmood, H., Khan, I. U., Asif, M., Khan, I. U., Asghar, S., Khalid, S. H., Khalid, S. H., Irfan, M., Rehman, F., Shahzad, Y., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.206 · Cited by 116 · see citing works
Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
Labib, R. M., Ayoub, I. M., Michel, H. E., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219561 · Cited by 96 · see citing works
“M . alternifolia essential oil displayed wide applications in dermatology, effectively treating multiple skin diseases and infections [36].”
Tea tree oil nanoemulsions for inhalation therapies of bacterial and fungal pneumonia
Li, M., Zhu, L., Liu, B., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.02.017 · Cited by 88 · see citing works
The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-ResistantCandida albicansStrains
Mertas, A., Garbusińska, A., Szliszka, E., et al. (2015) · BioMed Research International · doi:10.1155/2015/590470 · Cited by 82 · see citing works
“TTO is not mutagenic or genotoxic [34, 35].”
Essential oils pharmacological activity: Chemical markers, biogenesis, plant sources, and commercial products
Mohammed, H. A., Sulaiman, G. M., Khan, R. A., Al‐Saffar, A. Z., Mohsin, M. H., Albukhaty, S., & Ismail, A. (2024) · Process Biochemistry · doi:10.1016/j.procbio.2024.05.021 · Cited by 86 · see citing works
Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation
Amer, S. S., Nasr, M., Abdel-Aziz, R. T. A., Moftah, N. H., ElShaer, A., Polycarpou, E., Mamdouh, W., & Sammour, O. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119092 · Cited by 78 · see citing works
Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing: In-vitro and in-vivo wound healing assessment
Abdellatif, M. M., Elakkad, Y. E., A.EL-Wakeel, A., Allam, R. M., & Mousa, M. R. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.10.004 · Cited by 77 · see citing works
History of Natural Ingredients in Cosmetics
McMullen, R. L., & Dell’Acqua, G. (2023) · Cosmetics · doi:10.3390/cosmetics10030071 · Cited by 77 · see citing works
“As another example, the broadspectrum antimicrobial activity of tea tree oil protects against bacterial, viral, fungal, and protozoal infections of the skin [117].”
Background
Anti-Ulcer Activity of Essential Oil Constituents
Oliveira, F. D. A., Andrade, L. N., de Sousa, É. B. V., et al. (2014) · Molecules · doi:10.3390/molecules19055717 · Cited by 75 · see citing works
“[105], Malaleuca alternifolia Cheel [106], Origanum majorana L [107], as well as other species.”
Background
Rotational spectroscopy and three-wave mixing of 4-carvomenthenol: A technical guide to measuring chirality in the microwave regime
Shubert, V. A., Schmitz, D. W., Medcraft, C., et al. (2015) · The Journal of Chemical Physics · doi:10.1063/1.4921833 · Cited by 75 · see citing works
Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review
Nascimento, T., Gomes, D., Simões, R., & Miguel, M. G. (2023) · Antioxidants · doi:10.3390/antiox12061264 · Cited by 79 · see citing works
“The anti-inflammatory and antibacterial properties of TTO have been described and are mainly due to terpinen-4-ol [111], being widely used and studied in the treatment of acne.”
Background
Spray-by-spray in situ cross-linking alginate hydrogels delivering a tea tree oil microemulsion
Catanzano, O., Straccia, M. C., Miro, A., Ungaro, F., Romano, I., Mazzarella, G., Santagata, G., Quaglia, F., Laurienzo, P., & Malinconico, M. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.09.018 · Cited by 66 · see citing works
Antimicrobial activity of certain natural-based plant oils against the antibiotic-resistant acne bacteria
Esmael, A., Hassan, M. G., Amer, M. M., Abdelrahman, S., Hamed, A. M., Abd-raboh, H. A., & Foda, M. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.11.006 · Cited by 65 · see citing works
Tea tree oil presents in vitro antitumor activity on breast cancer cells without cytotoxic effects on fibroblasts and on peripheral blood mononuclear cells
Assmann, C. E., Cadoná, F. C., Bonadiman, B. D. S. R., Dornelles, E. B., Trevisan, G., & da Cruz, I. B. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.096 · Cited by 59 · see citing works
Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal
Amer, S. S., Mamdouh, W., Nasr, M., ElShaer, A., Polycarpou, E., Abdel-Aziz, R. T. A., & Sammour, O. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121309 · Cited by 57 · see citing works
Metabolomic Analysis and Mode of Action of Metabolites of Tea Tree Oil Involved in the Suppression of Botrytis cinerea
Xu, J., Shao, X., Li, Y., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01017 · Cited by 57 · see citing works
“Tea tree oil (TTO), the volatile essential oil extracted from leaves and branches of the Australian native plantMelaleuca alternifolia by steam distillation, is frequently used as a topical medicinal and antimicrobial agent (Pazyar et al., 2013).”
Background
Influence of Melaleuca alternifolia oil nanoparticles on aspects of Pseudomonas aeruginosa biofilm
Comin, V. M., Lopes, L. Q. S., Quatrin, P. M., de Souza, M. E., Bonez, P. C., Pintos, F. G., Raffin, R. P., Vaucher, R. D. A., Martinez, D. S. T., & Santos, R. C. V. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.019 · Cited by 55 · see citing works
Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
Martile, M. D., Garzoli, S., Sabatino, M., Valentini, E., D’Aguanno, S., Ragno, R., & Bufalo, D. D. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00510-3 · Cited by 54 · see citing works
Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
Nakayama, K., Murata, S., Ito, H., Iwasaki, K., Villareal, M. O., Zheng, Y., Matsui, H., Isoda, H., & Ohkohchi, N. (2017) · Oncology Letters · doi:10.3892/ol.2017.6370 · Cited by 50 · see citing works
“plant native to Australia that is also known as the tea tree (11).”
Environmental toxicants and health adversities: A review on interventions of phytochemicals
Sokan‐Adeaga, A. A., Sokan–Adeaga, M. A., Sokan-Adeaga, E. D., Oparaji, A. N., Edris, H., Tella, E. O., Balogun, F. A., Aledeh, M., & Amubieya, O. E. (2023) · Journal of Public Health Research · doi:10.1177/22799036231181226 · Cited by 52 · see citing works
Tea Tree Oil versus Chlorhexidine Mouthwash in Treatment of Gingivitis: A Pilot Randomized, Double Blinded Clinical Trial
Ripari, F., Cera, A., Freda, M., Zumbo, G., Zara, F., & Vozza, I. (2020) · European Journal of Dentistry · doi:10.1055/s-0040-1703999 · Cited by 49 · see citing works
“versatile healer of ” Several studies 21–23 activity in the medical field.”
Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study
Kwon, H. H., Yoon, J. Y., Park, S. Y., Min, S., & Suh, D. H. (2014) · Dermatology · doi:10.1159/000362491 · Cited by 48 · see citing works
Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells
Banjerdpongchai, R., & Khaw-on, P. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.12.7537 · Cited by 47 · see citing works
“) (Paisooksantivatana and Buain, 2009), leaves and terminal branches of Melaleuca alternifolia (Myrtales: Myrtaceae) (Pazyar et al., 2013).”
Background
Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(ε-caprolactone) core-shell nanocapsules
da Silva, N. P., Pereira, E. D. C. R. L., Duarte, L. M., Freitas, J. C. D. O., de Almeida, C. G., Silva, T. P. D., Melo, R. C. N., Apolônio, A. C. M., de Oliveira, M. A. L., Brandão, H. D. M., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111371 · Cited by 47 · see citing works
Composition and Bioactivity of Essential Oil from Citrus grandis (L.) Osbeck ‘Mato Peiyu’ Leaf
Tsai, M.-L., Lin, C.-D., Khoo, K., Wang, M., Kuan, T.-K., Lin, W., Zhang, Y., & Wang, Y. (2017) · Molecules · doi:10.3390/molecules22122154 · Cited by 48 · see citing works
“Essential oils have been used as an alternative therapy for skin problems, such as the application of tea tree oil to treat acne vulgaris and dandruff [25].”
Background
Botanical and Phytochemical Therapy of Acne: A Systematic Review
Fisk, W. A., Lev‐Tov, H. A., & Sivamani, R. K. (2014) · Phytotherapy Research · doi:10.1002/ptr.5125 · Cited by 44 · see citing works
“Tea tree oil has a similar range of anti-acne activities including multiple antiinflammatory and antimicrobial effects (Pazyar et al., 2012).”
Background
Structural and therapeutic properties of Pluronic® P123/F127 micellar systems and their modulation by salt and essential oil
Ganguly, R., Kumar, S., Tripathi, A., Basu, M., Verma, G., Sarma, H. D., Chaudhari, D., Aswal, V. K., & Melo, J. S. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.113231 · Cited by 44 · see citing works
Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model
Rasteiro, V. M. C., Costa, A. C. B. P., Araújo, C. F., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-489 · Cited by 41 · see citing works
“alternifolia products [14].”
The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review.
Ezekwe, N., King, M., & Hollinger, J. C. (2020) · PubMed Central · Cited by 39 · see citing works
Topical Eucalyptol Ointment Accelerates Wound Healing and Exerts Antioxidant and Anti-Inflammatory Effects in Rats’ Skin Burn Model
Mohammed, H. A., Mohammed, S. A. A., Khan, O. F., & Ali, H. M. (2022) · Journal of Oleo Science · doi:10.5650/jos.ess22214 · Cited by 40 · see citing works
Non-antibiotic antimicrobial interventions and antimicrobial stewardship in wound care
Cooper, R., & Kirketerp‐Møller, K. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.6.355 · Cited by 39 · see citing works
Optimization and characterization of a novel tea tree oil-integrated poly (ε-caprolactone)/soy protein isolate electrospun mat as a wound care system
Doustdar, F., Ramezani, S., Ghorbani, M., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122218 · Cited by 39 · see citing works
Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres
Sathiyaseelan, A., Zhang, X., & Wang, M. (2023) · Nutrients · doi:10.3390/nu15061319 · Cited by 38 · see citing works
“Particularly, tea tree oil (TTO) extracted from Melaleuca alternifolia belongs to the Myrtaceae family, which is potent in antimicrobial skin infection, antioxidant, and anti-inflammatory properties due to its combination of various volatile compounds (terpinen-4-ol, γ-terpinene, α-terpinene, 1,8-cineole, Terpinolene,…”
Background
The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials
Proença, A. C., Luís, Â., & Duarte, A. P. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2011945 · Cited by 43 · see citing works
Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits
Mekkaoui, M., Assaggaf, H. M., Qasem, A. H., et al. (2021) · Foods · doi:10.3390/foods11010028 · Cited by 36 · see citing works
Tanshinone IIA loaded bioactive nanoemulsion for alleviation of lipopolysaccharide induced acute lung injury via inhibition of endothelial glycocalyx shedding
El‐Moslemany, R. M., El-Kamel, A. H., Allam, E. A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113666 · Cited by 36 · see citing works
“The effect of TSIIA, TTO and RL in inhibition of glycocalyx degradation could be explained by their pronounced anti-inflammatory [14,37,61,64 – 67] and antioxidant [72 – 74] properties.”
BackgroundMethod
Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk
Lü, Z., Wang, X., Zhang, T., et al. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.07.013 · Cited by 35 · see citing works
Importance of essential oils and current trends in use of essential oils (aroma therapy, agrofood, and medicinal usage)
Sharma, A., Gumber, K., Gohain, A., Bhatia, T., Sohal, H. S., Mutreja, V., & Bhardwaj, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91740-7.00002-5 · Cited by 36 · see citing works
Phytochemical and Safety Evaluations of Volatile Terpenoids from Zingiber cassumunar Roxb. on Mature Carp Peripheral Blood Mononuclear Cells and Embryonic Zebrafish
Mektrirat, R., Yano, T., Okonogi, S., et al. (2020) · Molecules · doi:10.3390/molecules25030613 · Cited by 34 · see citing works
“Moreover, both sabinene and terpinen-4-ol exhibit a broad spectrum of biological effects [19,20].”
Background
Sprayed Pickering emulsion with high antibacterial activity for wound healing
Bao, X., Wu, J., & Ma, G. (2020) · Progress in Natural Science Materials International · doi:10.1016/j.pnsc.2020.08.001 · Cited by 34 · see citing works
Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne
Bisht, A., Hemrajani, C., Rathore, C., Dhiman, T., Rolta, R., Upadhyay, N. K., Nidhi, P., Gupta, G., Dua, K., Chellappan, D. K., et al. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01092-4 · Cited by 34 · see citing works
“Researchers are currently focusing on newer promising herbal agents, including isolated molecules like azelaic acid (AzA) and essential oils obtained from the plant Melaleuca alternifolia [5, 6], having more minor side effects and bacterial resistance.”
Background
Medical Applications of Hydrogels in Skin Infections: A Review
Teng, Y., Li, S., Tang, H. R., Tao, X., Fan, Y., & Huang, Y. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s396990 · Cited by 34 · see citing works
“They can lead to a few adverse effects like local skin sensitization and irritation or incidences of bacterial resistance.(19,20) It is essential to co-administer AZA and TTO for reducing the risk of dose-responsive adverse effects and achieving synergistic effects.”
Background
The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic® F-127 Gel Formulations with Ketoconazole
Wróblewska, M., Szymańska, E., & Winnicka, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111326 · Cited by 33 · see citing works
“The concentration of KTZ and TTO was set based on commercially available products and according to the literature data [22].”
Method
Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations
Iacovelli, F., Romeo, A., Lattanzio, P., Ammendola, S., Battistoni, A., Frazia, S. L., Vindigni, G., Unida, V., Biocca, S., Gaziano, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512432 · Cited by 32 · see citing works
“Several papers described its broadspectrum antibacterial, antifungal, antiprotozoal and antiviral activities, and nowadays TTO is incorporated in different dermatological and oral hygiene products [1,4].”
Background
The relationship between lavender and tea tree essential oils and pediatric endocrine disorders: A systematic review of the literature
Hawkins, J., Hires, C., Dunne, E., & Baker, C. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102288 · Cited by 32 · see citing works
Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies
Infante, V. H. P., Campos, P. M. B. G. M., Gaspar, L. R., Darvin, M. E., Schleusener, J., Rangel, K. C., Meinke, M. C., & Lademann, J. M. (2022) · International Journal of Cosmetic Science · doi:10.1111/ics.12761 · Cited by 34 · see citing works
Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation
Kamel, R., Afifi, S. M., Abdou, A. M., et al. (2022) · Molecules · doi:10.3390/molecules27196143 · Cited by 31 · see citing works
“It helps the skin to heal by encouraging the formation of scar tissue [13].”
Background
Evaluation of Effectiveness of a Toothpaste Containing Tea Tree Oil and Ethanolic Extract of Propolis on the Improvement of Oral Health in Patients Using Removable Partial Dentures
Wiatrak, K., Morawiec, T., Rój, R., Kownacki, P., Nitecka-Buchta, A., Niedzielski, D., Wychowański, P., Machorowska-Pieniążęk, A., Cholewka, A., Baldi, D., et al. (2021) · Molecules · doi:10.3390/molecules26134071 · Cited by 31 · see citing works
Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry
Milutinovici, R. A., Chioran, D., Buzatu, R., Macasoi, I. G., Șușan, R. M., Chioibaş, R., Corlan, I. V., Tanase, A., Câlniceanu, H., Popovici, R. A., et al. (2021) · Plants · doi:10.3390/plants10102148 · Cited by 31 · see citing works
“Considering the phytochemical composition, tea tree essential oil comprises over 100 active compounds, including terpinen-4-ol and 1,8-cineole (Figure 14), with many therapeutic effects, such as antibacterial, antiviral, antifungal, antiprotozoal activities, wound healing and anticancer effects [156].”
Background
Corrosion Inhibition of Mild Steel and 304 Stainless Steel in 1 M Hydrochloric Acid Solution by Tea Tree Extract and Its Main Constituents
Kim, J., Shin, I., & Byeon, J.-W. (2021) · Materials · doi:10.3390/ma14175016 · Cited by 30 · see citing works
Multifunctional gelatin nanoparticle stabilized-Pickering emulsion hydrogel based on dextran and amikacin with controlled drug release and enhanced antibacterial capability for promoting infected wound healing
Zhang, R., Huang, X., Wu, Q., Chu, S., Bai, X., Zhou, Y., You, J., Yang, C., & Tan, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130172 · Cited by 29 · see citing works
Therapeutic benefits of natural oils along with permeation enhancing activity
Amra, K., Momin, M. M., Desai, N., & Khan, F. M. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15733 · Cited by 29 · see citing works
Dynamic mechanical analysis of novel cosmeceutical facial creams containing nano‐encapsulated natural plant and fruit extracts
Kalouta, K., Eleni, P. N., Boukouvalas, C. J., Vassilatou, K., & Krokida, M. K. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13133 · Cited by 28 · see citing works
Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing
de Assis, K. M. A., Leite, J. M. D. S., de Melo, D. F., Borges, J. C., Santana, L. M. B., dos Reis, M. M. L., Moreira, V. M., da Rocha, W. R. V., Catão, R. M. R., dos Santos, S. G., et al. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00850-0 · Cited by 27 · see citing works
Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs
Wang, L., Zhang, Y., Liu, L., Huang, F., & Dong, B. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.789225 · Cited by 27 · see citing works
“Tea tree oil (TTO) is an essential oil steam-distilled from Melaleuca alternifolia (5).”
Background
Phytochemicals as Multi-Target Therapeutic Agents for Oxidative Stress-Driven Pathologies: Mechanisms, Synergies, and Clinical Prospects
Mubeen, B., Hasnain, A., Naqvi, S. A. H., Hakim, F., Naqvi, S. S. H., Hassan, M. Z., Iqbal, M. U., Moustafa, M., Alshaharni, M. O., & Duan, M. (2025) · Phyton · doi:10.32604/phyton.2025.064056 · Cited by 25 · see citing works
“Since several antioxidant phytochemicals were discovered to have anti-inflammatory activities, IBD was strongly connected with them [245].”
Mid-infrared spectroscopy for the rapid quantification of eucalyptus oil adulteration in Australian tea tree oil (Melaleuca alternifolia)
Johnson, J. B., Thani, P. R., Mani, J. S., Cozzolino, D., & Naiker, M. (2022) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2022.121766 · Cited by 24 · see citing works
Quality-by-Design Approach for the Development of Nano-Sized Tea Tree Oil Formulation-Impregnated Biocompatible Gel with Antimicrobial Properties
Muta, T., Parikh, A. R., Kathawala, K., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111091 · Cited by 24 · see citing works
“Their degradation causes skin irritation, allergic reactions, odor, and color changes [2,8,9].”
Background
Essential Oils as Potential Source of Anti‐Dandruff Agents: A Review
Arora, P., Nainwal, L. M., & Jain, S. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207324666210712094148 · Cited by 23 · see citing works
A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris
Lubtikulthum, P., Kamanamool, N., & Udompataikul, M. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12962 · Cited by 23 · see citing works
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
Wart Immunotherapies: A Short Review
Sefcik, R., & Burkhart, C. G. (2017) · The Open Dermatology Journal · doi:10.2174/1874372201711010030 · Cited by 22 · see citing works
Effects of tea tree essential oil supplementation in low fish meal diet on growth, lipid metabolism, anti-oxidant capacity and immunity of largemouth bass (Micropterus salmoides)
Liu, X., Deng, H., Xu, Q., Luo, K., Jiang, Z., Gao, W., Wang, Z., Zhang, H., & Zhou, X. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101380 · Cited by 22 · see citing works
Essential Oil with Anticancer Activity: An Overview
Angelini, P., Tirillini, B. B., Akhtar, M. S., et al. (2018) · Springer eBooks · doi:10.1007/978-981-10-8064-7_9 · Cited by 22 · see citing works
Antiparasitic Activity of Tea Tree Oil (TTO) and Its Components against Medically Important Ectoparasites: A Systematic Review
Abrha, S., Tesfaye, W. H., Christenson, J. K., Carson, C. F., & Thomas, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081587 · Cited by 20 · see citing works
Seeking new acne treatment from natural products, devices and synthetic drug discovery
Yang, J. H., Yoon, J. Y., Kwon, H. H., Min, S., Moon, J., & Suh, D. H. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1356520 · Cited by 20 · see citing works
Tackling scabies: novel agents for a neglected disease
Gopinath, H., Aishwarya, M., & Karthikeyan, K. (2018) · International Journal of Dermatology · doi:10.1111/ijd.13999 · Cited by 21 · see citing works
Melaleuca alternifolia Essential Oil: Evaluation of Skin Permeation and Distribution from Topical Formulations with a Solvent-Free Analytical Method
Capetti, F., Sgorbini, B., Cagliero, C., et al. (2020) · Planta Medica · doi:10.1055/a-1115-4848 · Cited by 20 · see citing works
“TTO is widely used because of its recognized biological activities [5–7], in particular, as an ingredient in formulations to treat skin diseases, including acne, seborrheic dermatitis [8], scabies [9], and dandruff.”
Background
Tea tree oil nanoliposomes: optimization, characterization, and antibacterial activity against Escherichia coli in vitro and in vivo
Bo, R., Zhan, Y., Wei, S., Xu, S., Huang, Y., Liu, M., & Li, J. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102238 · Cited by 20 · see citing works
Oral Health of Patients Treated with Acrylic Partial Dentures Using a Toothpaste Containing Bee Product
Wiatrak, K., Morawiec, T., Rój, R., et al. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/4034179 · Cited by 20 · see citing works
Antimicrobial activity of some Essential oils and Extracts from Natural sources on Skin and Soft tissue infection causing microbes: An In-vitro Study
Subramanian, S., Shenoy, P. A., & Pai, V. (2021) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2021.00623 · Cited by 19 · see citing works
Cosmetic Formulations with Melaleuca alternifolia Essential Oil for the Improvement of Photoaged Skin: A Double‐Blind , Randomized, Placebo‐Controlled Clinical Study
Infante, V. H. P., Campos, P. M. B. G. M., Darvin, M. E., Lohan, S. B., Schleusener, J., Schanzer, S., Lademann, J. M., & Meinke, M. C. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13660 · Cited by 19 · see citing works
“Additionally, terpinen-4-ol modulates vasodilation and plasma extravasation (57).”
Background
Formulation and characterization of tea tree and jojoba oils nano-emulgel for in-vivo wound healing assessment
Mohamed, N. K., Metwally, A. A., Fared, S. M. Y., Farid, A., & Taha, M. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114312 · Cited by 19 · see citing works
Terpinen4-ol inhibits heat stress induced inflammation in colonic tissue by Activating Occludin, Claudin-2 and TLR4/NF-κB signaling pathway
Mohyuddin, S. G., Qamar, A., Hu, C., Li, Y., Chen, S., Wen, J., Bao, M., & Ju, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107727 · Cited by 18 · see citing works
Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial.
Attarzadeh, Y., Asilian, A., Shahmoradi, Z., & Adibi, N. (2013) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
Characterization and Efficacy of Essential Oil-Based Cosmetic Formulations for Acne-Prone Skin
Infante, V. H. P., Darvin, M. E., & Campos, P. M. B. G. M. (2023) · Cosmetics · doi:10.3390/cosmetics10060158 · Cited by 17 · see citing works
Recent advances in the application of tea tree oil in the storage of fruit and vegetables
Deng, X., Wei, Y., Jiang, S., et al. (2024) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2024.113260 · Cited by 16 · see citing works
GC-MS Chemical profile, Antioxidant Activity, and Sun Protection Factor of Essential Oil of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis L.)
Malik, P., & Upadhyay, P. (2022) · Oriental Journal Of Chemistry · doi:10.13005/ojc/380524 · Cited by 16 · see citing works
Comparison of chitosan and SLN nano-delivery systems for antibacterial effect of tea tree (Melaleuca alternifolia) oil against P. aeruginosa and S. aureus
Vase, H., Nemattalab, M., Rohani, M., et al. (2023) · Letters in Applied Microbiology · doi:10.1093/lambio/ovad130 · Cited by 16 · see citing works
Detection of eucalyptus oil adulteration in Australian tea tree oil using UV–Vis and fluorescence spectroscopy
Johnson, J. B., Thani, P. R., & Naiker, M. (2022) · Talanta Open · doi:10.1016/j.talo.2022.100169 · Cited by 15 · see citing works
Cosmetic Industry: Natural Secondary Metabolites for Beauty and Aging
Saraiva, S. M., Miguel, S. P., Araújo, A. R. T. S., Rodrigues, M., Ribeiro, M. P., & Coutinho, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_27 · Cited by 15 · see citing works
Comparative Antimicrobial Activity of Tea Tree Oil (Melaleuca Oil) and Common Topical Antimicrobials against Bacteria Associated With Wound and Topical Infections
Singh, B. R., Prasanna Vadhana, A., Bhardwaj, M., et al. (2016) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000513 · Cited by 15 · see citing works
“Discussion Tea Tree oil is seen as potential oil to replace the use of antibiotics for topical use [19] and shown to inhibit many different types of bacteria [1,5,10].”
Background
Micellar structural transitions and therapeutic properties in tea tree oil solubilized pluronic P123 solution
Ganguly, R., Kunwar, A., Kota, S., Kumar, S., & Aswal, V. K. (2017) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2017.10.045 · Cited by 15 · see citing works
Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues
Nazeam, J. A., Ragab, G. M., El-Gazar, A. A., El-Mancy, S. S., Jamil, L., & Fayez, S. M. (2021) · Molecules · doi:10.3390/molecules26185608 · Cited by 14 · see citing works
Application of Gellan Gum Biopolymer in Biomedical Applications: A Review
Hishamuddin, N., Razali, M. H., & Mat Amin, K. A. (2022) · Makara Journal of Science · doi:10.7454/mss.v26i1.1271 · Cited by 13 · see citing works
“Tea tree oil also boosts wound healing through its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory activities [54].”
Background
Analysis of biologically active oxyprenylated phenylpropanoids in Tea tree oil using selective solid-phase extraction with UHPLC-PDA detection
Scotti, L., Genovese, S., Bucciarelli, T., Martini, F., Epifano, F., Fiorito, S., Preziuso, F., & Taddeo, V. A. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.03.004 · Cited by 13 · see citing works
“These are represented y acne [1], scabias [2], impetigo [3], seborrheic dermatitis [4], nd several others [5].”
Background
Microsponge Based Gel of Tea Tree Oil for Dermatological Microbial Infections
Yadav, E., Rao, R., Kumar, S., et al. (2018) · The Natural Products Journal · doi:10.2174/2210315508666180605080426 · Cited by 12 · see citing works
The Effect of Successive Harvesting on The Volatile Constituents of Two Essential Oils of Cultivated Populations of Sea Fennel (Crithmum maritimum L.) in Greece
Zafeiropoulou, V., Tomou, E., Douros, A., et al. (2021) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2021.1875054 · Cited by 12 · see citing works
Antimicrobial textiles from natural resources: types, properties and processing
Saha, J., & Mondal, M. I. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821485-5.00016-0 · Cited by 12 · see citing works
A hydrogel sheet mask with tea tree essential oil entrapment and targeted dose delivery capability
Ghosh, B., Bhattacharya, D., & Mukhopadhyay, M. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.01.349 · Cited by 13 · see citing works

Broth micro-dilution method for determining the susceptibility of Escherichia coli and Staphylococcus aureus to the essential oil of Melaleuca alternifolia (tea tree oil).
Carson, C. F., Hammer, K. A., & Riley, T. V. (1995) · PubMed · Cited by 190 · see citing works
An Overview on Tea Tree (Melaleuca Alternifolia) Oil
Lahkar, S. (2014) · International Journal of Pharmaceutical and Phytopharmacological Research · Cited by 6 · see citing works
Review Article An Overview on Tea Tree (Melaleuca Alternifolia) Oil
Lahkar, S., Lahkar, S., Das, M. K., et al. (2016) · Cited by 1 · see citing works
[Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil)].
Fritz, T., Burg, G., & Krasovec, M. (2001) · PubMed · Cited by 40 · see citing works
The Effect of Tea Tree Oil ( Melaleuca alternifolia ) on Wound Healing Using a Dressing Model
Chin, K. B., & Cordell, B. (2013) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2012.0787 · Cited by 46 · see citing works

Authors: Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A.
Affiliations: Ahvaz Jundishapur University of Medical Sciences (IR)
Corresponding author: Pazyar, Nader
ORCID: Pazyar, Nader
Yaghoobi, Reza
Bagherani, Nooshin
Venue: International Journal of Dermatology
Publisher: Wiley
Published: 2012-09-24
Volume: 52
Issue: 7
Pages: 784-790
ISSN: 0011-9059 (ISSN-L)
1365-4632
DOI: 10.1111/j.1365-4632.2012.05654.x
OpenAlex: W2016711385
Semantic Scholar: 8af9fc3638195427a56def3e97838ca793b73aea
Cited by: 252
References: 46
Citations by year: 2026: 14 · 2025: 23 · 2024: 23 · 2023: 32 · 2022: 37 · 2021: 31 · 2020: 23 · 2019: 15 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 7 · 2013: 4
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: tea tree oil, Melaleuca alternifolia, terpinen-4-ol, 1,8-cineole, antimicrobial activity, anti-inflammatory activity, antioxidant activity, acne, seborrheic dermatitis, chronic gingivitis, wound healing, anticancer activity, herbal medicine, skin infections
MeSH terms: Anti-Infective Agents, Local, Humans, Skin Diseases, Tea Tree Oil

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A review of applications of tea tree oil in dermatology

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks