Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models

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Evidence against the presence of an anandamide transporter

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The anandamide transport inhibitor AM404 activates vanilloid receptors

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CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

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Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172

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The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

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Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

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Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404

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Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat

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A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain

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Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity

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Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

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Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat

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AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

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Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]

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Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain

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Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system

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Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons

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Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors

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3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects

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AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation

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The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

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The Endocannabinoid System and Pain

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Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

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Paracetamol – An old drug with new mechanisms of action

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TRPV1 in Brain Is Involved in Acetaminophen-Induced Antinociception

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AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

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Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

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Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes

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Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

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2-Arachidonoylglycerol and Anandamide Oppositely Modulate Norepinephrine Release from the Rat Heart Sympathetic Nerves

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The endocannabinoid system mediates aerobic exercise-induced antinociception in rats

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