Cited by 108Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsIon Channels and Receptors

Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

Siegling, Angela, Hofmann, Heiko A, Denzer, Dirk, Mauler, Frank, De Vry, Jean·2001·European Journal of Pharmacology

Abstract

Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB(1) receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a rat model of chronic neuropathic pain, and hypothesize that cannabinoid CB(1) receptor upregulation contributes to the increased analgesic efficacy of cannabinoids in chronic pain conditions.

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Registry

Crossref · 10.1016/s0014-2999(01)00798-1

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8 of 8 references verified0 citation errors · 0 not checkable

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  • Tibial nerve injury resulted in upregulation of CB1 receptor mRNA in the contralateral thalamus on day 1 post-surgery.

    “TNI injury resulted in an upregulation of CB1 receptor mRNA in the contralateral thalamus on day 1 post-surgery,106 indicating cannabinoid receptor regulation within an important relay nucleus in the ascending pain pathway.”

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Authors
Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J.
Affiliations
Bayer (Germany) (DE)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2001-03
Volume
415
Issue
1
Pages
R5-R7
ISSN
0014-2999 (ISSN-L)
OpenAlex
W1986938130
Cited by
108
References
8
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
4.64
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
CB1 receptor, receptor up-regulation, chronic neuropathic pain, sciatic nerve axotomy, thalamus, cannabinoid analgesia, rat model
MeSH terms
Animals, Chronic Disease, Disease Models, Animal, Gene Expression Regulation, Neuralgia, Receptors, Drug, RNA, Messenger, Sciatic Nerve, Thalamus, Up-Regulation, Rats, Wistar, Receptors, Cannabinoid, Rats

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