Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain
Abstract
Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB(1) receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a rat model of chronic neuropathic pain, and hypothesize that cannabinoid CB(1) receptor upregulation contributes to the increased analgesic efficacy of cannabinoids in chronic pain conditions.
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Tibial nerve injury resulted in upregulation of CB1 receptor mRNA in the contralateral thalamus on day 1 post-surgery.
“TNI injury resulted in an upregulation of CB1 receptor mRNA in the contralateral thalamus on day 1 post-surgery,106 indicating cannabinoid receptor regulation within an important relay nucleus in the ascending pain pathway.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [106]
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- Authors
- Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J.
- Affiliations
- Bayer (Germany) (DE)
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 415
- Issue
- 1
- Pages
- R5-R7
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1986938130
- Cited by
- 108
- References
- 8
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- CB1 receptor, receptor up-regulation, chronic neuropathic pain, sciatic nerve axotomy, thalamus, cannabinoid analgesia, rat model
- MeSH terms
- Animals, Chronic Disease, Disease Models, Animal, Gene Expression Regulation, Neuralgia, Receptors, Drug, RNA, Messenger, Sciatic Nerve, Thalamus, Up-Regulation, Rats, Wistar, Receptors, Cannabinoid, Rats
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