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Cited by 98Exercise and Physiological ResponsesMuscle Physiology and DisordersNutrition and Health in Aging

Biochemical changes in response to intensive resistance exercise training in the elderly

Bautmans, Ivan, Njemini, Rose, Vasseur, Sabine, Chabert, Hans, Moens, Lisa, Demanet, Christian, Mets, Tony·2005·Gerontology
DOI 10.1159/000085122
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Abstract

BACKGROUND: It is assumed that low-grade inflammation, characterized by increased circulating IL-6 and TNF-alpha, is related to the development of sarcopenia. Physical exercise, especially high intensity resistance training, has been shown to be effective in restoring the strength deficit in the elderly. Intensive exercise is accompanied by significant release of IL-6 and TNF-alpha into the blood circulation, but does not result in muscle wasting. Exercise-induced changes in heat-shock protein (Hsp), responsible for cellular protection during stressful situations, might interfere with the acute phase reaction and muscle adaptation. OBJECTIVE: To investigate if intensive strength training in elderly persons induces changes in Hsp70 expression, and if these changes are related to changes in the acute phase reaction or muscle adaptation. METHODS: 31 elderly persons (aged 68.4+/-5.4 years) performed 6 weeks' intensive strength training. At baseline and after 6 weeks, muscle strength, functional performance (physical activity profile, 6-min walk, 30- second chair stand, grip strength, chair sit & reach and back scratch), linear isokinetic leg extension, circulating IL-6, TNF-alpha, IL-10 and TGF-beta, and Hsp70 in monocytes (M) and lymphocytes (L) immediately after sampling (IAS), after incubation at 37 and 42 degrees C were determined. In 12 participants, cytokines were determined in untrained and trained conditions before and after a single training session. RESULTS: After 6 weeks' training, muscle strength and functional performance improved significantly, together with decreased Hsp70 IAS and Hsp70 37 degrees C and increased Hsp70 42 degrees C (all p<0.05). Strength gains correlated positively with baseline Hsp70 37 degrees C and training-induced changes of Hsp70 42 degrees C in M and L. In an untrained condition, training induced an increase of IL-6 (p<0.05) and a tendency of IL-10 to decrease (p=0.06). In a trained condition the decrease of IL-10 disappeared. Baseline physical activity and 6-min walk distance correlated negatively with circulating IL-6 (p<0.05); except for a negative correlation between TGF-beta and Hsp70 37 degrees C L (p<0.05), no significant relationships were found between cytokines and Hsp70. After the training program, Hsp70 37 degrees C was negatively related to circulating TNF-alpha, IL-10 and TGF-beta. CONCLUSION: Strength training in the elderly induces changes in Hsp70 expression, associated to strength gains and circulating cytokines.

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  • Higher iron intake, especially haem iron, and higher iron status are associated with increased risk of type 2 diabetes, atherosclerosis and coronary heart disease, although the literature is not fully consistent.

    “There is some epidemiological evidence that higher Fe intake, particularly that of haem Fe, and higher Fe status are associated with increased risk of type 2 diabetes, atherosclerosis and CHD (702 -714) , although not all of the literature is consistent.”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [704]

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Authors
Bautmans, I., Njemini, R., Vasseur, S., Chabert, H., Moens, L., Demanet, C., & Mets, T.
Affiliations
  • Vrije Universiteit Brussel (BE)
  • Université Libre de Bruxelles (BE)
ORCID
Venue
Gerontology
Publisher
S. Karger AG
Published
2005
Volume
51
Issue
4
Pages
253-265
ISSN
  • 0304-324X (ISSN-L)
  • 1423-0003
DOI
10.1159/000085122
OpenAlex
W2087895652
Cited by
98
References
120
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 11
FWCI
3.89
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
resistance training, older adults, sarcopenia, HSP70, acute phase response, cytokines, interleukin-6, TNF-α, IL-10, TGF-beta, muscle strength, functional performance, muscle adaptation, low-grade inflammation, monocytes, lymphocytes, physical activity, isokinetic leg extension, grip strength
MeSH terms
Acute-Phase Reaction, Aged, Female, Humans, Leukocytes, Mononuclear, Male, Tumor Necrosis Factor-alpha, Exercise, Interleukin-6, Transforming Growth Factor beta, Interleukin-10, Muscle, Skeletal, HSP70 Heat-Shock Proteins

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