Cited by 92Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Increased soluble tumor necrosis factor‐α receptors in patients with major depressive disorder

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Grassi‐Oliveira, Rodrigo, Brietzke, Elisa, Pezzi, Júlio C., Lopes, Rodrigo P., Teixeira, Antonio L., Bauer, Moisés E.·2009·Psychiatry and Clinical Neurosciences

Abstract

Aim: Several lines of evidence suggest that major depressive disorder is associated with an inflammatory status. Tumor necrosis factor‐α has been investigated as a potential molecular target in mood disorders. Tumor necrosis factor‐α exerts its activity through binding to specific cell membrane receptors named as TNFR1 and TNFR2. The aim of the present study was to investigate soluble plasma TNFR1 (sTNFR1) and TNFR2 levels (sTNFR2) in major depressive disorder patients. Methods: Female outpatients with major depressive disorder (n = 30) were compared with a healthy control group (n = 19). Severity of depressive symptoms was evaluated on Beck Depression Inventory; post‐traumatic stress disorder (PTSD) symptoms were evaluated on PTSD Checklist–Civilian Version; and childhood abuse and neglect on the Childhood Trauma Questionnaire. Plasma tumor necrosis factor‐α and its soluble receptors were measured by ELISA. Results: Patients had no changes in tumor necrosis factor‐α concentrations but did have increased sTNFR1 (P < 0.001) and sTNFR2 (P < 0.001) levels compared to controls. Plasma level of sTNFR1 was positively predicted by age (B = 0.25, P = 0.05) and PTSD‐like symptoms (B = 0.41, P = 0.002) and plasma levels of sTNFR2 by depression severity (B = 0.67, P < 0.001). Conclusions: Soluble tumor necrosis factor‐α receptors could be reliable markers of inflammatory activity in major depression.

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Crossref · 10.1111/j.1440-1819.2008.01918.x

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  1. 26 Berger W, Mendlowicz MV, Souza W, Figueira I. Semantic equivalence of the Portuguese version of the Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C) for the screening of post-traumatic stress disorder. Rev. Psiquiatr. Rio Gd Sul 2004; 26 : 167-175.
  2. 28 Grassi-Oliveira R, Stein LM, Pezzi JC. Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language. Rev. Saude Publica 2006; 40 : 249-255.

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Authors
Grassi‐Oliveira, R., Brietzke, E., Pezzi, J. C., Lopes, R. P., Teixeira, A. L., & Bauer, M. E.
Affiliations
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
  • Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Grassi‐Oliveira, Rodrigo
Venue
Psychiatry and Clinical Neurosciences
Publisher
Wiley
Published
2009-03-20
Volume
63
Issue
2
Pages
202-208
ISSN
  • 1323-1316 (ISSN-L)
  • 1440-1819
OpenAlex
W1837581479
Cited by
92
References
40
Citations by year
2026: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 8
FWCI
3.40
Type
journal article
Language
en
Open access
Locations
  • Psychiatry and Clinical Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, TNFR1, TNFR2, inflammation, inflammatory markers, posttraumatic stress symptoms, childhood abuse and neglect, depression severity, plasma cytokines
MeSH terms
Adult, Child, Child Abuse, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Surveys and Questionnaires, Tumor Necrosis Factor-alpha, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Young Adult

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