Increased soluble tumor necrosis factor‐α receptors in patients with major depressive disorder
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Aim: Several lines of evidence suggest that major depressive disorder is associated with an inflammatory status. Tumor necrosis factor‐α has been investigated as a potential molecular target in mood disorders. Tumor necrosis factor‐α exerts its activity through binding to specific cell membrane receptors named as TNFR1 and TNFR2. The aim of the present study was to investigate soluble plasma TNFR1 (sTNFR1) and TNFR2 levels (sTNFR2) in major depressive disorder patients. Methods: Female outpatients with major depressive disorder (n = 30) were compared with a healthy control group (n = 19). Severity of depressive symptoms was evaluated on Beck Depression Inventory; post‐traumatic stress disorder (PTSD) symptoms were evaluated on PTSD Checklist–Civilian Version; and childhood abuse and neglect on the Childhood Trauma Questionnaire. Plasma tumor necrosis factor‐α and its soluble receptors were measured by ELISA. Results: Patients had no changes in tumor necrosis factor‐α concentrations but did have increased sTNFR1 (P < 0.001) and sTNFR2 (P < 0.001) levels compared to controls. Plasma level of sTNFR1 was positively predicted by age (B = 0.25, P = 0.05) and PTSD‐like symptoms (B = 0.41, P = 0.002) and plasma levels of sTNFR2 by depression severity (B = 0.67, P < 0.001). Conclusions: Soluble tumor necrosis factor‐α receptors could be reliable markers of inflammatory activity in major depression.
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Serum/plasma levels of sTNFR2 are increased in MDD patients.
“Grassi-Oliveira et al. and Diniz et al. also reported increased serum/plasma levels of sTNFR2 in MDD patients”
From Selected biomarkers of depression: what are the effects of cytokines and inflammation (2022) · cites this paper as [212]
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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419 · see citing works
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,353 · see citing works
TNF-R1 Signaling: A Beautiful Pathway
Chen, G., & Goeddel, D. V. (2002) · Science · doi:10.1126/science.1071924 · Cited by 1,930 · see citing works
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · see citing works
(1996) · PubMed · Cited by 863 · see citing works
Zee, K. J. V., Kohno, T., Fischer, E., Rock, C. S., Moldawer, L. L., & Lowry, S. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4845 · Cited by 845 · see citing works
Two tumour necrosis factor receptors: structure and function
Vandenabeele, P., Declercq, W., Beyaert, R., & Fiers, W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89088-1 · Cited by 799 · see citing works
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works
Cytokines and the Brain: Implications for Clinical Psychiatry
Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784 · see citing works
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Elevated inflammation levels in depressed adults with a history of childhood maltreatment
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.409 · Cited by 641 · see citing works
Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 587 · see citing works
Shedding of tumor necrosis factor receptors by activated human neutrophils.
Porteu, F., & Nathan, C. F. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.2.599 · Cited by 437 · see citing works
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., & Eisel, U. L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311766200 · Cited by 424 · see citing works
von Känel, R., Hepp, U., Kraemer, B., Traber, R., Keel, M., Mica, L., & Schnyder, U. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.06.009 · Cited by 408 · see citing works
Measuring Socioeconomic Status
Cirino, P. T., Chin, C. E., Sevcik, R. A., Wolf, M., Lovett, M. W., & Morris, R. D. (2002) · Assessment · doi:10.1177/10791102009002005 · Cited by 371 · see citing works
Tradução e validação de conteúdo da versão em português do Childhood Trauma Questionnaire
Grassi‐Oliveira, R., Stein, L. M., & Pezzi, J. C. (2006) · Revista de Saúde Pública · doi:10.1590/s0034-89102006000200010 · Cited by 369 · see citing works
Self-citationInflammation, Depression and Dementia: Are they Connected?
Leonard, B. E. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9385-y · Cited by 342 · see citing works
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis
Diez‐Ruiz, A., Tilz, G. P., Zangerle, R., Baier‐Bitterlich, G., WACHTER, H., & Fuchs, D. (1995) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1995.tb01618.x · Cited by 306 · see citing works
Nery, F. G., Monkul, E. S., Hatch, J. P., Fonseca, M., Zunta‐Soares, G. B., Frey, B. N., Bowden, C. L., & Soares, J. C. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.912 · Cited by 298 · see citing works
Lang, A. J., Laffaye, C., Satz, L. E., Dresselhaus, T. R., & Stein, M. B. (2003) · Journal of Traumatic Stress · doi:10.1023/a:1023796007788 · Cited by 202 · see citing works
TNF-α as a molecular target in bipolar disorder
Brietzke, E., & Kapczinski, F. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.006 · Cited by 163 · see citing works
Self-citationDifferences in cytokines between non-suicidal patients and suicidal patients in major depression
Kim, Y.-K., Lee, S.-W., Kim, S.-H., Shim, S.-H., Han, S.-W., Choi, S.-H., & Lee, B.-H. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.041 · Cited by 140 · see citing works
Veenema, A. H., Reber, S. O., Selch, S., Obermeier, F., & Neumann, I. D. (2008) · Endocrinology · doi:10.1210/en.2007-1469 · Cited by 138 · see citing works
Successful Antidepressant Therapy Restores the Disturbed Interplay Between TNF-α System and HPA Axis
Himmerich, H., Binder, E. B., Kunzel, H. E., Schuld, A., Lucae, S., Uhr, M., Pollmächer, T., Holsboer, F., & Ising, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.075 · Cited by 120 · see citing works
Loftis, J. M., Huckans, M. S., Ruimy, S., Hinrichs, D. J., & Hauser, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.001 · Cited by 117 · see citing works
Function and Regulation of Tumor Necrosis Factor Receptor Type 2
Carpentier, I., Coornaert, B., & Beyaert, R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364694 · Cited by 112 · see citing works
Yang, K., Xie, G., Zhang, Z., Wang, C., Li, W., Zhou, W., & Tang, Y. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670601057759 · Cited by 100 · see citing works
Döme, P., Teleki, Z., Ríhmer, Z., Peter, L., Dobos, J., Kenessey, I., Tóvári, J., Tı́már, J., Paku, S., Kovács, G. L., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002138 · Cited by 99 · see citing works
Berger, W., Mendlowicz, M. V., de Souza, W. F., & Figueira, I. L. D. V. (2004) · Revista de Psiquiatria do Rio Grande do Sul · doi:10.1590/s0101-81082004000200006 · Cited by 99 · see citing works
Increased Soluble Tumor Necrosis Factor Receptor Levels in the Serum of Elderly People
Hasegawa, Y., Sawada, M., Ozaki, N., Inagaki, T., & Suzumura, A. (2000) · Gerontology · doi:10.1159/000022157 · Cited by 79 · see citing works
Alaaeddine, N., Battista, J. A. D., Pelletier, J., Cloutier, J. M., Kiansa, K., Dupuis, M., & Martel‐Pelletier, J. (1997) · PubMed · Cited by 76 · see citing works
Moorman, A. J., Mozaffarian, D., Wilkinson, C. W., Lawler, R. L., McDonald, G. B., Crane, B. A., Spertus, J. A., Russo, J. E., Stempien‐Otero, A., Sullivan, M. D., et al. (2007) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.06.301 · Cited by 49 · see citing works
Alessandri, A. L., Souza, A. L., Oliveira, S. C., Macedo, G. C., Teixeira, M. M., & Teixeira, A. L. (2006) · Inflammation Research · doi:10.1007/s00011-006-5136-9 · Cited by 48 · see citing works
Self-citationFriebe, A., Schwarz, M., Schmid-Wendtner, M.-H., Volkenandt, M., Schmidt, F., Horn, M., Janssen, G., & Schaefer, M. (2007) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211346.19330.c9 · Cited by 26 · see citing works
Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy
Pouly, S., Antel, J. P., Ladiwala, U., Nalbantoglu, J. N., & Becher, B. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6284-2_16 · Cited by 25 · see citing works
Circulating TNF-α and its soluble receptors during experimental acute pancreatitis
Granell, S., Pereda, J., Gómez-Cambronero, L., Fernández, N. C., Sabater, L., Closa, D., & Sastre, J. (2003) · Cytokine · doi:10.1016/j.cyto.2003.10.011 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- 26 Berger W, Mendlowicz MV, Souza W, Figueira I. Semantic equivalence of the Portuguese version of the Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C) for the screening of post-traumatic stress disorder. Rev. Psiquiatr. Rio Gd Sul 2004; 26 : 167-175.
- 28 Grassi-Oliveira R, Stein LM, Pezzi JC. Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language. Rev. Saude Publica 2006; 40 : 249-255.
Cited by
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A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
Humphreys, K. L., LeMoult, J., Wear, J. G., Piersiak, H. A., Lee, A., & Gotlib, I. H. (2020) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2020.104361 · Cited by 591 · see citing works
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
Childhood maltreatment and inflammatory markers: a systematic review.
Coelho, R., Viola, T. W., Walss‐Bass, C., Brietzke, E., & Grassi‐Oliveira, R. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12217 · Cited by 426 · see citing works
Self-citationDomenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
Selected biomarkers of depression: what are the effects of cytokines and inflammation
Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works
The roles of TNF in brain dysfunction and disease
Clark, I. A., Alleva, L. M., & Vissel, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.007 · Cited by 232 · see citing works
The inflammation hypothesis in geriatric depression
Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 225 · see citing works
Gibney, S. M., McGuinness, B. W., Prendergast, C., Harkin, A., & Connor, T. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.11.010 · Cited by 220 · see citing works
Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis
Tursich, M., Neufeld, R. W. J., Frewen, P. A., Harricharan, S., Kibler, J. L., Rhind, S. G., & Lanius, R. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.56 · Cited by 204 · see citing works
Examining the role of neuroinflammation in major depression
Furtado, M., & Katzman, M. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.06.009 · Cited by 191 · see citing works
Microglial dysfunction connects depression and Alzheimer’s disease
Santos, L. E., Beckman, D., & Ferreira, S. T. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.011 · Cited by 119 · see citing works
Bortolato, B., F. Carvalho, A., K. Soczynska, J., I. Perini, G., & S. McIntyre, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150630171433 · Cited by 142 · see citing works
Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment
Xu, Y., Wang, C., Klabnik, J., & Donnell, J. O. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120231448 · Cited by 139 · see citing works
Ledo, J. H., Azevedo, E. P., Beckman, D., Ribeiro, F. C., Santos, L. E., Razolli, D. S., Kincheski, G. C., Melo, H. M., Bellio, M., Teixeira, A. L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1269-16.2016 · Cited by 137 · see citing works
Self-citationInflammatory mediators of cognitive impairment in bipolar disorder
Bauer, I. E., Pascoe, M. C., Wollenhaupt-Aguiar, B., Kapczinski, F. P., & Soares, J. C. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.017 · Cited by 133 · see citing works
Chiang, J. J., Lam, P. H., Chen, E., & Miller, G. E. (2022) · Psychological Bulletin · doi:10.1037/bul0000351 · Cited by 126 · see citing works
The putative neurodegenerative links between depression and Alzheimer's disease
Wuwongse, S., Chang, R. C., & Law, A. C. K. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.005 · Cited by 124 · see citing works
Scalzo, P. L., Kümmer, A., Cardoso, F., & Teixeira, A. L. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.08.001 · Cited by 118 · see citing works
Self-citationIncreased plasma levels of soluble TNF receptor I in patients with bipolar disorder.
Barbosa, I. G., Huguet, R. B., Mendonça, V. A., Sousa, L. P., Neves, F. S., Bauer, M. E., & Teixeira, A. L. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-010-0116-z · Cited by 108 · see citing works
Self-citationSowa-Kućma, M., Styczeń, K., Siwek, M., Misztak, P., Nowak, R. J., Dudek, D., Rybakowski, J. K., Nowak, G., & Maes, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.024 · Cited by 104 · see citing works
Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation
Hughes, M. M., Carballedo, A., McLoughlin, D. M., Amico, F., Harkin, A., Frodl, T., & Connor, T. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.010 · Cited by 104 · see citing works
Fernandez-Botrán, R., Miller, J. J., Burns, V. E., & Newton, T. L. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.023 · Cited by 103 · see citing works
Asevedo, E. D. M., Gadelha, A., Noto, C. D. S., Mansur, R. B., Zugman, A., Belangero, S. I., Berberian, A. D. A., Scarpato, B. S., Leclerc, E., Teixeira, A. L., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.032 · Cited by 99 · see citing works
Self-citationHigher Serum sTNFR1 Level Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease
Diniz, B. S., Teixeira, A. L., Ojopi, E. P. B., Talib, L. L., Mendonça, V. A., Gattaz, W. F., & Forlenza, O. V. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100921 · Cited by 99 · see citing works
Self-citationFarr, O. M., Ko, B.-J., Joung, K. E., Zaichenko, L., Usher, N., Tsoukas, M., Thakkar, B., Davis, C. R., Crowell, J. A., & Mantzoros, C. S. (2015) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.01.007 · Cited by 93 · see citing works
Park, M., Newman, L. E., Gold, P. W., Luckenbaugh, D. A., Yuan, P., Machado-Vieira, R., & Zarate, C. A. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.025 · Cited by 93 · see citing works
Peripheral Chemokine Levels in Women with Recurrent Major Depression with Suicidal Ideation
Grassi-Oliveira, R., Brieztke, E., Teixeira, A., Pezzi, J. C., Zanini, M., Lopes, R. P., & Bauer, M. E. (2012) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462012000100013 · Cited by 91 · see citing works
Self-citationSowa-Kućma, M., Styczeń, K., Siwek, M., Misztak, P., Nowak, R. J., Dudek, D., RYBAKOWSKI, J. K., Nowak, G., & Maes, M. H. J. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9835-5 · Cited by 88 · see citing works
Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
TANURE, M. T. D. A., Gómez, R. S., Hurtado, R. C. L., Teixeira, A. L., & Domingues, R. B. (2010) · The Journal of Headache and Pain · doi:10.1007/s10194-010-0233-0 · Cited by 77 · see citing works
Self-citationInterplay between Neuroimmunoendocrine Systems during Post-Traumatic Stress Disorder: A Minireview
Bauer, M. E., Wieck, A., Lopes, R. P., Teixeira, A. L., & Grassi‐Oliveira, R. (2010) · NeuroImmunoModulation · doi:10.1159/000258721 · Cited by 74 · see citing works
Self-citationTargeting cytokines in reduction of depressive symptoms: A comprehensive review
Shariq, A. S., Brietzke, E., Rosenblat, J. D., Barendra, V., Pan, Z., & McIntyre, R. S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.003 · Cited by 72 · see citing works
Self-citationKuwano, N., Kato, T. A., Mitsuhashi, M., Sato‐Kasai, M., Shimokawa, N., Hayakawa, K., Ohgidani, M., Sagata, N., Kubo, H., Sakurai, T., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.040 · Cited by 69 · see citing works
Mansur, R. B., Delgado‐Peraza, F., Subramaniapillai, M., Lee, Y. L., Iacobucci, M., Rodrigues, N. B., Rosenblat, J. D., Brietzke, E. M., Cosgrove, V. E., Kramer, N. E., et al. (2020) · Cells · doi:10.3390/cells9040895 · Cited by 67 · see citing works
Self-citationCampos, A. C., Vaz, G. N., Saito, V. M., & Teixeira, A. L. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.06.039 · Cited by 64 · see citing works
Self-citationInterleukin-6 and verbal memory in recurrent major depressive disorder.
Grassi‐Oliveira, R., Bauer, M. E., Pezzi, J. C., Teixeira, A. L., & Brietzke, E. M. (2011) · PubMed · Cited by 64 · see citing works
Self-citationAsevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63 · see citing works
Self-citationMansur, R. B., Zugman, A., Asevedo, E. D. M., da Cunha, G. R., Bressan, R. A., & Brietzke, E. M. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02354.x · Cited by 55 · see citing works
Self-citationChocano-Bedoya, P. O., Mirzaei, F., O’Reilly, É. J., Lucas, M., Okereke, O. I., Hu, F. B., Rimm, E. B., & Ascherio, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.03.023 · Cited by 55 · see citing works
Increased Soluble TNF Receptor 2 in Antidepressant-Free Patients with Late-Life Depression
Diniz, B. S., Teixeira, A. L., Talib, L. L., Mendonça, V. A., Gattaz, W. F., & Forlenza, O. V. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.008 · Cited by 54 · see citing works
Self-citationTumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
Baune, B. T., Camara, M.-L., Eyre, H. A., Jawahar, M. C., Anscomb, H., & Körner, H. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0027-8 · Cited by 50 · see citing works
Hoyo-Becerra, C., Huebener, A., Trippler, M., Lutterbeck, M., Liu, Z. J., Truebner, K., Bajanowski, T., Gerken, G., Hermann, D. M., & Schlaak, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083149 · Cited by 49 · see citing works
Lopes, R. P., Grassi‐Oliveira, R., de Almeida, L. R., Stein, L. M., Luz, C., Teixeira, A. L., & Bauer, M. E. (2011) · NeuroImmunoModulation · doi:10.1159/000327352 · Cited by 49 · see citing works
Self-citationLitteljohn, D., Cummings, A., Brennan, A., Gill, A., Chunduri, S., Anisman, H., & Hayley, S. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.001 · Cited by 46 · see citing works
Chen, M., Chang, W.-C., Hsu, J.-W., Huang, K., Tu, P., Su, T., Li, C., Lin, W.-C., & Bai, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.106 · Cited by 44 · see citing works
Viana, A. F., Maciel, I. D. S., Dornelles, F. N., Figueiredo, C. P., Siqueira, J. M., Campos, M. M., & Calixto, J. Β. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-98 · Cited by 44 · see citing works
Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia
Noto, C. D. S., Gadelha, A., Belangero, S. I., Spíndola, L., Rocha, N. P., de Miranda, A. S., Teixeira, A. L., Smith, M. D. A. C., Mari, J. D. J., Bressan, R. A., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.010 · Cited by 41 · see citing works
Self-citationHori, H., Yoshimura, R., Katsuki, A., Atake, K., Igata, R., Konishi, Y., & Nakamura, J. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1212172 · Cited by 39 · see citing works
Huckans, M. S., Fuller, B. E., Olavarria, H., Sasaki, A. W., Chang, M., Flora, K. D., Kolessar, M., Kříž, D., Anderson, J. R., Vandenbark, A. A., et al. (2013) · Brain and Behavior · doi:10.1002/brb3.200 · Cited by 38 · see citing works
Druzhkova, T., Pochigaeva, K., Yakovlev, A., Kazimirova, E., Grishkina, M., Chepelev, A., Guekht, A., & Gulyaeva, N. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-018-0367-3 · Cited by 37 · see citing works
Insights into inflammation and epilepsy from the basic and clinical sciences
Silveira, G., de Oliveira, A. C. P., & Teixeira, A. L. (2012) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2011.10.011 · Cited by 33 · see citing works
Self-citationTeixeira, A. L., Souza, R. T. D. A., Zanetti, M. V., Brunoni, A. R., Busatto, G. F., Zarate, C. A., Gattaz, W. F., & Machado‐Vieira, R. (2015) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2450 · Cited by 32 · see citing works
Self-citationEarly life stress and tumor necrosis factor superfamily in crack cocaine withdrawal
Levandowski, M. L., Viola, T. W., Wearick‐Silva, L. E., Wieck, A., Tractenberg, S. G., Brietzke, E. M., Bauer, M. E., Teixeira, A. L., & Grassi‐Oliveira, R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.02.017 · Cited by 31 · see citing works
Self-citationInamdar, A., Merlo‐Pich, E., Gee, M., Makumi, C. W., Mistry, P. C., Robertson, J., Steinberg, E., Zamuner, S., Learned, S. M., Alexander, R., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114529377 · Cited by 30 · see citing works
Ogłodek, E. A., Just, M. J., Szromek, A. R., & Araszkiewicz, A. S. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.04.013 · Cited by 29 · see citing works
Immunity, Aging, and Geriatric Depression
Morimoto, S. S., & Alexopoulos, G. S. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.006 · Cited by 28 · see citing works
Schmidt, F. M., Koch, J., Nowak, C., Holdt, L. M., Teupser, D., Hegerl, U., & Himmerich, H. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.09.010 · Cited by 27 · see citing works
Wieck, A., Grassi‐Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Vieira, É. L. M., Teixeira, A. L., & Bauer, M. E. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.040 · Cited by 26 · see citing works
Self-citationEllis, R. J., Letendre, S. L., Atkinson, J. H., Clifford, D. B., Collier, A. C., Gelman, B. B., Marra, C. M., McCutchan, J. A., Morgello, S., Sacktor, N. C., et al. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100121 · Cited by 26 · see citing works
Hu, L., Kawamoto, E. M., Brietzke, E. M., Scavone, C., & Lafer, B. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.031 · Cited by 24 · see citing works
Self-citationSmiley, C. E., & Wood, S. K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108212 · Cited by 23 · see citing works
Brunoni, A. R., Machado‐Vieira, R., Sampaio-Júnior, B., Vieira, É. L. M., Valiengo, L. D. C. L., Benseñor, I. M., Lotufo, P. A., Carvalho, A. F., Cho, H. J., Gattaz, W. F., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.006 · Cited by 23 · see citing works
Self-citationHeo, S., Moser, D. K., Pressler, S. J., Dunbar, S. B., Dekker, R. L., & Lennie, T. A. (2014) · American Journal of Critical Care · doi:10.4037/ajcc2014614 · Cited by 22 · see citing works
Psychosocial and Biological Indicators of Depression in the Caregiving Population
Clark, M. C., Nicholas, J., Wassira, L. N., & Gutierrez, A. P. (2011) · Biological Research For Nursing · doi:10.1177/1099800411414872 · Cited by 20 · see citing works
Recent Progress in Biosensors for Depression Monitoring—Advancing Personalized Treatment
Yin, J., Jia, X., Li, H., Zhao, B., Yang, Y. A., & Ren, T. (2024) · Biosensors · doi:10.3390/bios14090422 · Cited by 14 · see citing works
Brietzke, E. M., & Teixeira, A. L. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00822.x · Cited by 14 · see citing works
Self-citationMeta-analysis of soluble tumour necrosis factor receptors in severe mental illnesses
Goh, X. X., Tang, P. Y., & Tee, S. F. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.07.014 · Cited by 13 · see citing works
Deveci, E., Kocacenk, T., Şahan, E., Yılmaz, O., Öztürk, A., & Kırpınar, İ. (2019) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2019.1589176 · Cited by 12 · see citing works
Himmerich, H., Wesemann, U., Dalton, B., Holdt, L. M., Teupser, D., & Willmund, G. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.11.001 · Cited by 9 · see citing works
Depression in patients with ankylosing spondylitis
Ma, T., Geng, Y., & Li, P. (2022) · Rheumatology & autoimmunity · doi:10.1002/rai2.12020 · Cited by 7 · see citing works
Luo, G., Jing, Y., Yang, J., Wang, S., Xuekelaiti, Z., Yao, C., Gao, Y. H., Chen, H., Sun, D., Li, J., et al. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02781-3 · Cited by 5 · see citing works
Memon, N. H., Fan, M., Lin, J., Si, Y. J., Su, M., Guo, Q., & Fang, D. Z. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061075 · Cited by 4 · see citing works
Zorbozan, N., Demir, S., & Çobankara, V. (2018) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2017-0350 · Cited by 3 · see citing works
Gonçalves, G. S., Duarte, R. C. F., Campos, F. M. F., Silva, I. D. F. O., Sousa, L. P., Faria, M. C., Martins‐Filho, O. A., Bicalho, M. A. C., de Moraes, E. N., Teixeira, A. L., et al. (2016) · European Geriatric Medicine · doi:10.1016/j.eurger.2016.05.001 · Cited by 3 · see citing works
Self-citationBoyajyan, A., Mkrtchyan, G., Hovhannisyan, L. P., & Avetyan, D. (2013) · InTech eBooks · doi:10.5772/52693 · Cited by 3 · see citing works
PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV
Haddadi, S., Jordan-Sciutto, K. L., Akay, C., Grelotti, D., Letendre, S. L., Tang, B., & Ellis, R. J. (2023) · Journal of Neurology and Psychology · doi:10.13188/2332-3469.1000049 · Cited by 2 · see citing works
Dean, B., Seymour, N., & Gibbons, A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.016 · Cited by 2 · see citing works
Bermúdez, C. M. (2012) · Revista Colombiana de Psiquiatría · doi:10.1016/s0034-7450(14)60075-5 · Cited by 1 · see citing works
(2015) · Healthy Aging Research · doi:10.12715/har.2015.4.17 · Cited by 1 · see citing works
Pan, Z. (2018) · TSpace (University of Toronto) · Cited by 1 · see citing works
Kapoor, S. N. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0044-5
Pestana, G. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Fancourt, D. E. (2016) · UCL Discovery (University College London)
Immune dysregulation in bipolar disorder
Teixeira, A. L., Barbosa, I. G., & Bauer, M. E. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781107477278.022
Self-citationGardhouse, K. (2020) · TSpace (University of Toronto)
Zhang, Y., Sun, L., Zhao, Y., Zhang, Z., Chen, H., Zhao, M., Miao, Z., Wang, W., Xu, X., & Initiative, A. D. N. (2026) · BMC Medicine · doi:10.1186/s12916-026-04623-3
Kalidasan, Y., Venkatesan, V., Kantipudi, S. J., & Ramachandran, I. (2026) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000609
- Authors
- Grassi‐Oliveira, R., Brietzke, E., Pezzi, J. C., Lopes, R. P., Teixeira, A. L., & Bauer, M. E.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Grassi‐Oliveira, Rodrigo
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2009-03-20
- Volume
- 63
- Issue
- 2
- Pages
- 202-208
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1837581479
- Cited by
- 92
- References
- 40
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 8
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, TNFR1, TNFR2, inflammation, inflammatory markers, posttraumatic stress symptoms, childhood abuse and neglect, depression severity, plasma cytokines
- MeSH terms
- Adult, Child, Child Abuse, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Surveys and Questionnaires, Tumor Necrosis Factor-alpha, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Young Adult
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