Cited by 163Bipolar Disorder and TreatmentTryptophan and brain disordersTreatment of Major Depression

TNF-α as a molecular target in bipolar disorder

Brietzke, Elisa, Kapczinski, Flávio·2008·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

The pathophysiology of bipolar disorder (BD) is poorly understood. An emerging body of evidence points to impairments in neuroplasticity, cell resilience and neuronal survival as the main neuropathological correlates of BD. It has been suggested that inflammatory cytokines, particularly TNF-alpha may play a critical role in this process. In the present review we examine the evidence suggesting that TNF-alpha regulates apoptotic cascades which may be related to neuronal and glial loss in BD. Current evidence suggests that an increase in serum levels of TNF-alpha takes place during manic and depressive episodes. The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD.

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Crossref · 10.1016/j.pnpbp.2008.01.006

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  • TNF-α antagonists such as adalimumab, etanercept, and infliximab are currently being used in clinical trials to treat depressive episodes in patients with bipolar disorder.

    “TNF-α antagonists, such as adalimumab, etanercept, and infliximab, have been used as therapeutic agents for rheumatic diseases, and are currently being used in clinical trials to treat the depressive episodes of patients with bipolar disorder[64].”
  • Current evidence suggests that TNF-α regulates apoptotic cascades that may be associated with neuronal and glial loss in bipolar disorder.

    “Current evidence suggests that TNF-α regulates apoptotic cascades that may be associated with neuronal and glial loss in bipolar disorder.”

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Authors
Brietzke, E., & Kapczinski, F.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Kapczinski, Flávio
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2008-08
Volume
32
Issue
6
Pages
1355-1361
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2003038736
Cited by
163
References
58
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 18 · 2012: 8
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
TNF-α, bipolar disorder, neuroinflammation, inflammatory cytokines, apoptosis, neuroplasticity, neuronal survival, manic and depressive episodes, serum TNF-α levels, therapeutic target
MeSH terms
Animals, Bipolar Disorder, Cell Survival, Cognition Disorders, Humans, Tumor Necrosis Factor-alpha, Cytokines, NF-kappa B, Apoptosis, Antimanic Agents, Mood Disorders

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