TNF-α as a molecular target in bipolar disorder
Abstract
The pathophysiology of bipolar disorder (BD) is poorly understood. An emerging body of evidence points to impairments in neuroplasticity, cell resilience and neuronal survival as the main neuropathological correlates of BD. It has been suggested that inflammatory cytokines, particularly TNF-alpha may play a critical role in this process. In the present review we examine the evidence suggesting that TNF-alpha regulates apoptotic cascades which may be related to neuronal and glial loss in BD. Current evidence suggests that an increase in serum levels of TNF-alpha takes place during manic and depressive episodes. The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TNF-α antagonists such as adalimumab, etanercept, and infliximab are currently being used in clinical trials to treat depressive episodes in patients with bipolar disorder.
“TNF-α antagonists, such as adalimumab, etanercept, and infliximab, have been used as therapeutic agents for rheumatic diseases, and are currently being used in clinical trials to treat the depressive episodes of patients with bipolar disorder[64].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [64]
Current evidence suggests that TNF-α regulates apoptotic cascades that may be associated with neuronal and glial loss in bipolar disorder.
“Current evidence suggests that TNF-α regulates apoptotic cascades that may be associated with neuronal and glial loss in bipolar disorder.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [64]
Cites
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071 · see citing works
Mortality of patients with mood disorders: follow-up over 34–38 years
Angst, F., Stassen, H. H., Clayton, P. J., & Angst, J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00377-9 · Cited by 881 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Cytokines and the Brain: Implications for Clinical Psychiatry
Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784 · see citing works
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659 · see citing works
Roles for NF-κB in nerve cell survival, plasticity, and disease
Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 597 · see citing works
Functional outcome in bipolar disorder: the role of clinical and cognitive factors
Martínez‐Arán, A., Vieta, E., Torrent, C., Sánchez‐Moreno, J., Goikolea, J. M., Salamero, M., Malhi, G. S., González-Pinto, A. M., Daban, C., Alvarez-Grandi, S. A., et al. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00327.x · Cited by 586 · see citing works
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
Robinson, L. J., & Ferrier, I. N. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00277.x · Cited by 533 · see citing works
The Increasing Medical Burden in Bipolar Disorder
Kupfer, D. J. (2005) · JAMA · doi:10.1001/jama.293.20.2528 · Cited by 489 · see citing works
Cunha, A. B. M., Frey, B. N., Andreazza, A. C., Goi, J. D., Rosa, A. R., Gonçalves, C. A., Santin, A. M. P., & Kapczinski, F. P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.085 · Cited by 391 · see citing works
Self-citationImbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder
Kim, Y.-K., Jung, H.-G., Myint, A.-M., Kim, H., & Park, S.-H. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.02.018 · Cited by 375 · see citing works
Strakowski, S. M., DelBello, M. P., Zimmerman, M. E., Getz, G. E., Mills, N. P., Ret, J., Shear, P. K., & Adler, C. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1841 · Cited by 363 · see citing works
Manji, H. K., Duman, R. S., Duman, F. A. R. S., & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4260 · Cited by 330 · see citing works
Progressive Gray Matter Loss in Patients with Bipolar Disorder
Moorhead, T. W. J., McKirdy, J. W., Sussmann, J. E., Hall, J., Lawrie, S. M., Johnstone, E. C., & McIntosh, A. M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.005 · Cited by 319 · see citing works
Cytokine imbalance in the pathophysiology of major depressive disorder
Kim, Y., Na, K.-S., Shin, K.-H., Jung, H., Choi, S., & Kim, J.-B. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.004 · Cited by 312 · see citing works
Behavioral Effects of Cytokines
Larson, S. J., & Dunn, A. J. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0643 · Cited by 295 · see citing works
Role of BDNF in bipolar and unipolar disorder: Clinical and theoretical implications
Post, R. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.09.009 · Cited by 286 · see citing works
Cytokine profiles in bipolar affective disorder: focus on acutely ill patients.
O'Brien, S. M., Scully, P., Scott, L. V., & Dinan, T. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.11.015 · Cited by 285 · see citing works
Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance
Blondeau, N., Widmann, C., Lazdunski, M., & Heurteaux, C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04668.2001 · Cited by 271 · see citing works
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study.
Tobinick, E. L., Gross, H., Weinberger, A., & Cohen, H. (2006) · PubMed Central · Cited by 271 · see citing works
NF-??B Activation and Inhibition: A Review
Sun, Z., & Andersson, R. (2002) · Shock · doi:10.1097/00024382-200208000-00001 · Cited by 263 · see citing works
Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder
Schloesser, R. J., Huang, J. Y., Klein, P. S., & Manji, H. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301575 · Cited by 256 · see citing works
NF-κB in the Survival and Plasticity of Neurons
Mattson, M. P. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6961-x · Cited by 255 · see citing works
Glycogen synthase kinase‐3β, mood stabilizers, and neuroprotection
Li, X., Bijur, G. N., & Jope, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.40201.x · Cited by 238 · see citing works
Volumetric brain imaging findings in mood disorders
Beyer, J. L., & Krishnan, K. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01157.x · Cited by 231 · see citing works
Structural brain abnormalities in first-episode mania
Strakowski, S. M., Wilson, D. R., Tohen, M. F., Woods, B. T., Douglass, A. W., & Stoll, A. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90098-x · Cited by 204 · see citing works
Cell pathology in bipolar disorder
Rajkowska, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01149.x · Cited by 202 · see citing works
An update on regional brain volume differences associated with mood disorders
Campbell, S., & MacQueen, G. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000194371.47685.f2 · Cited by 198 · see citing works
Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB
Ichiyama, T., Okada, K., Lipton, J. M., Matsubara, T., Hayashi, T., & Furukawa, S. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02439-7 · Cited by 196 · see citing works
Identifying Functional Neuroimaging Biomarkers of Bipolar Disorder: Toward DSM-V
Phillips, M. L., & Vieta, E. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm060 · Cited by 193 · see citing works
Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?
Strakowski, S. M., Adler, C. M., & DelBello, M. P. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01160.x · Cited by 188 · see citing works
Blumberg, H. P., Krystal, J. H., Bansal, R., Martin, A., Dziura, J., Durkin, K., Martin, L., Gerard, E., Charney, D. S., & Peterson, B. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.031 · Cited by 171 · see citing works
Cytokines in Depression and Heart Failure
Pasic, J., Levy, W. C., & Sullivan, M. D. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000058372.50240.38 · Cited by 167 · see citing works
Persistent Neuropsychological Deficit in Euthymic Bipolar Patients
Mur, M., Portella, M. J., Martínez‐Arán, A., Pifarré, J., & Vieta, E. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0715 · Cited by 166 · see citing works
The underlying neurobiology of bipolar disorder.
Manji, H. K., Quiroz, J. A., Payne, J. L., Singh, J., Lopes, B. P., Viegas, J. S., & Zarate, C. A. (2003) · Europe PMC (PubMed Central) · Cited by 160 · see citing works
Receptor-Mediated Choreography of Life and Death
Bhardwaj, A., & Aggarwal, B. B. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1025319031417 · Cited by 150 · see citing works
Differences in cytokines between non-suicidal patients and suicidal patients in major depression
Kim, Y.-K., Lee, S.-W., Kim, S.-H., Shim, S.-H., Han, S.-W., Choi, S.-H., & Lee, B.-H. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.041 · Cited by 140 · see citing works
Gosselin, D., & Rivest, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.004 · Cited by 130 · see citing works
Mood stabilizers, glycogen synthase kinase-3β and cell survival
Jope, R. S., & Bijur, G. N. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001017 · Cited by 130 · see citing works
Depression: What We can Learn from Postmortem Studies
Rajkowska, G. (2003) · The Neuroscientist · doi:10.1177/1073858403252773 · Cited by 114 · see citing works
Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells
Bournat, J. C., Brown, A. M. C., & Soler, A. P. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000701)61:1 · Cited by 100 · see citing works
Yang, K., Xie, G., Zhang, Z., Wang, C., Li, W., Zhou, W., & Tang, Y. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670601057759 · Cited by 100 · see citing works
Penetration of neurotrophins and cytokines across the blood–brain/blood–spinal cord barrier
Pan, W., & Kastin, A. J. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00086-6 · Cited by 97 · see citing works
Tumor necrosis factor-α, microglia and astrocytes in AIDS dementia complex
Seilhean, D., Kobayashi, K., He, Y., Uchihara, T., Rosenblum, O., Katlama, C., Bricaire, F., Duyckaerts, C. J., & Hauw, J. (1997) · Acta Neuropathologica · doi:10.1007/s004010050646 · Cited by 76 · see citing works
Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder
Sun, Y., Johnston, N. L., Yolken, R. H., Zhang, L., & Fullertorrey, E. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.41.s137 · Cited by 66 · see citing works
Lithium Induces NF-κB Activation and Interleukin-8 Production in Human Intestinal Epithelial Cells
Németh, Z. H., Deitch, E. A., Szabó, C., Fekete, Z., Hauser, C. J., & Haskó, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109711200 · Cited by 59 · see citing works
Structural brain changes in bipolar disorder using deformation field morphometry
Soares, J. C., Kochunov, P. V., Monkul, E. S., Nicoletti, M., Brambilla, P., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Lancaster, J. L., et al. (2005) · Neuroreport · doi:10.1097/00001756-200504250-00004 · Cited by 51 · see citing works
Glial cell number and neuron/glial cell ratios in postmortem brains of bipolar individuals
BRAUCH, R., ADNANELMASRI, M., PARKERJR, J., & El‐Mallakh, R. S. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.08.015 · Cited by 50 · see citing works
Sui, Z., Sniderhan, L. F., Fan, S., Kaźmierczak, K., Reisinger, E., Kovács, A., Potash, M. J., Dewhurst, S., Gelbard, H. A., & Maggirwar, S. B. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04813.x · Cited by 44 · see citing works
Pae, C., Lee, K. U., Han, H. J., Serretti, A., & Jun, T. (2003) · Psychiatry Research · doi:10.1016/j.psychres.2003.06.002 · Cited by 38 · see citing works
Macdonald, N. J., Delderfield, S. M., Zhang, W., & Taglialatela, G. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00059.x · Cited by 22 · see citing works
Furuno, T., & Nakanishi, M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.031 · Cited by 22 · see citing works
Flagged first, then by citations
2 of the 58 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works
Self-citationAggarwal, B. B., Gupta, S. C., & Kim, J. H. (2012) · Blood · doi:10.1182/blood-2011-04-325225 · Cited by 877 · see citing works
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works
Self-citationRao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.47 · Cited by 432 · see citing works
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Brietzke, E., Stertz, L., Fernandes, B. S., Kauer-Sant’Anna, M., Mascarenhas, M., Escosteguy Vargas, A., Chies, J. A., & Kapczinski, F. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.001 · Cited by 423 · see citing works
Self-citationBiomarkers and clinical staging in psychiatry
McGorry, P. D., Keshavan, M. S., Goldstone, S. D., Amminger, G. P., Allott, K., Berk, M., Lavoie, S., Pantelis, C., Yung, A. R., Wood, S. J., et al. (2014) · World Psychiatry · doi:10.1002/wps.20144 · Cited by 305 · see citing works
Mondelli, V., Cattaneo, A., Murri, M. B., Forti, M. D., Handley, R., Hepgul, N., Miorelli, A., Navari, S., Papadopoulos, A. S., Aitchison, K. J., et al. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06745 · Cited by 305 · see citing works
Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works
Ahmmed, M. K., Ahmmed, F., Tian, H. S., Carne, A., & Bekhit, A. E. A. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12510 · Cited by 245 · see citing works
A role for white matter abnormalities in the pathophysiology of bipolar disorder
Mahon, K., Burdick, K. E., & Szeszko, P. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.012 · Cited by 227 · see citing works
Fillman, S. G., Sinclair, D., Fung, S. J., Webster, M. J., & Shannon Weickert, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.8 · Cited by 226 · see citing works
Kunz, M., Ceresér, K. M. M., Goi, P. D., Fries, G. R., Teixeira, A. L., Fernandes, B. S., Belmonte-de-Abreu, P. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. S. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000300010 · Cited by 189 · see citing works
Self-citationScaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 184 · see citing works
Rosenblat, J. D., Brietzke, E., Mansur, R. B., Maruschak, N. A., Lee, Y., & McIntyre, R. S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.058 · Cited by 172 · see citing works
Self-citationThe potential use of biomarkers as an adjunctive tool for staging bipolar disorder
Kapczinski, F. P., Dias, V. V., Kauer‐Sant’Anna, M., Brietzke, E. M., Vázquez, G. H., Vieta, E., & Berk, M. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.027 · Cited by 167 · see citing works
Self-citationMood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus
Soczynska, J. K., Kennedy, S. H., Woldeyohannes, H. O., Liauw, S. S. L., Alsuwaidan, M. T., Yim, C. Y., & McIntyre, R. S. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8140-8 · Cited by 162 · see citing works
Tumor necrosis factor alpha in sleep regulation
Rockstrom, M. D., Chen, L., Taishi, P., Nguyen, J., Gibbons, C. M., Veasey, S. C., & Krueger, J. M. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.10.005 · Cited by 164 · see citing works
Hope, S., Melle, I. S., Aukrust, P., Steen, N. E., Birkenaes, A. B., Lorentzen, S., Agartz, I., Ueland, T., & Andreassen, O. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00757.x · Cited by 152 · see citing works
Abnormalities in serum chemokine levels in euthymic patients with Bipolar Disorder
Brietzke, E. M., Kauer‐Sant’Anna, M., Teixeira, A. L., & Kapczinski, F. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.008 · Cited by 127 · see citing works
Self-citationVieta, E., Reinares, M., & Rosa, A. R. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9197-8 · Cited by 120 · see citing works
The role of neuroinflammation and neurovascular dysfunction in major depressive disorder
Jeon, S. W., & Kim, Y. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141033 · Cited by 120 · see citing works
State-dependent microstructural white matter changes in bipolar I depression
Zanetti, M. V., Jackowski, M. P., Versace, A., Almeida, J., Hassel, S., Duran, F., Busatto, G. F., Kupfer, D. J., & Phillips, M. L. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0002-8 · Cited by 114 · see citing works
Staging and Neuroprogression in Bipolar Disorder: A Systematic Review of the Literature
Gama, C. S., Kunz, M., Magalhães, P. V. D. S., & Kapczinski, F. P. (2013) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.09.001 · Cited by 112 · see citing works
Self-citationIncreased plasma levels of soluble TNF receptor I in patients with bipolar disorder.
Barbosa, I. G., Huguet, R. B., Mendonça, V. A., Sousa, L. P., Neves, F. S., Bauer, M. E., & Teixeira, A. L. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-010-0116-z · Cited by 108 · see citing works
Cytokine levels in euthymic bipolar patients
Guloksuz, S., Aktas Cetin, E., Cetin, T., Deniz, G., Oral, E. T., & Nutt, D. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.027 · Cited by 102 · see citing works
Watkins, C. C., Sawa, A., & Pomper, M. G. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.119 · Cited by 100 · see citing works
Asevedo, E. D. M., Gadelha, A., Noto, C. D. S., Mansur, R. B., Zugman, A., Belangero, S. I., Berberian, A. D. A., Scarpato, B. S., Leclerc, E., Teixeira, A. L., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.032 · Cited by 99 · see citing works
Self-citationFrom neuroprogression to neuroprotection: implications for clinical care.
Berk, M., Conus, P., Kapczinski, F. P., Andreazza, A. C., Yücel, M., Wood, S. J., Pantelis, C., Malhi, G. S., Dodd, S., Bechdolf, A., et al. (2010) · PubMed · Cited by 96 · see citing works
Self-citationSoczynska, J. K., Kennedy, S. H., Goldstein, B. I., Lachowski, A. M., Woldeyohannes, H. O., & McIntyre, R. S. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.03.004 · Cited by 93 · see citing works
Vasconcelos-Moreno, M. P., Fries, G. R., Gubert, C., dos Santos, B. T. M. Q., Fijtman, A., Sartori, J., Ferrari, P., Grün, L. K., Parisi, M. M., Guma, F. T. C. R., et al. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx001 · Cited by 92 · see citing works
Self-citationIncreased soluble tumor necrosis factor‐α receptors in patients with major depressive disorder
Grassi‐Oliveira, R., Brietzke, E., Pezzi, J. C., Lopes, R. P., Teixeira, A. L., & Bauer, M. E. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2008.01918.x · Cited by 92 · see citing works
Self-citationRege, S., & Hodgkinson, S. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413499077 · Cited by 90 · see citing works
Levels of TNF‐α, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder
Baysal, Ö. D., Ci̇nemre, B., Aksoy, U. M., Akbas, H. S., Metin, Ö., Fettahoğlu, E. Ç., Gökmen, Z., & Davran, F. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2301 · Cited by 84 · see citing works
Luo, Y., He, H., Zhang, M., Huang, X., & Fan, N. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.07.027 · Cited by 83 · see citing works
Staging Models in Bipolar Disorder: A Systematic Review of the Literature
Muneer, A. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.2.117 · Cited by 76 · see citing works
Maes, M. H. J., Rachayon, M., Jirakran, K., Sodsai, P., Klinchanhom, S., Gałecki, P., Sughondhabirom, A., & Basta‐Kaim, A. (2022) · Cells · doi:10.3390/cells11071183 · Cited by 69 · see citing works
Hamdani, N., Daban, C., Lajnef, M., Gadel, R., Corvoisier, P. L., Delavest, M., Carde, S., Lépine, J., Jamain, S., Houenou, J., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.038 · Cited by 65 · see citing works
Insulin dysfunction and allostatic load in bipolar disorder
Brietzke, E. M., Kapczinski, F. P., Grassi‐Oliveira, R., Grande, I., Vieta, E., & McIntyre, R. S. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.185 · Cited by 64 · see citing works
Self-citationInterleukin-6 and verbal memory in recurrent major depressive disorder.
Grassi‐Oliveira, R., Bauer, M. E., Pezzi, J. C., Teixeira, A. L., & Brietzke, E. M. (2011) · PubMed · Cited by 64 · see citing works
Self-citationAsevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63 · see citing works
Self-citationWalker, A. J., Kim, Y., Price, J. B., Kale, R. P., McGillivray, J., Berk, M., & Tye, S. J. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00034 · Cited by 63 · see citing works
Evidence for an association between tumor necrosis factor-alpha levels and lithium response
Gülöksüz, S., Altınbaş, K., Çetin, E. A., Kenis, G., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.044 · Cited by 55 · see citing works
Mansur, R. B., Zugman, A., Asevedo, E. D. M., da Cunha, G. R., Bressan, R. A., & Brietzke, E. M. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02354.x · Cited by 55 · see citing works
Self-citationCampbell, I. H., & Campbell, H. J. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110299 · Cited by 56 · see citing works
Maes, M. H. J., Nani, J. V. S., Noto, C. D. S., Rizzo, L. B., Hayashi, M. A. F., & Brietzke, E. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02110-1 · Cited by 54 · see citing works
Self-citationBrietzke, E. M., Mansur, R. B., Soczynska, J. K., Powell, A. M., & McIntyre, R. S. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.004 · Cited by 53 · see citing works
Self-citationSong, Y., Wu, B. C., Yang, Y., Chen, J., Zhang, L. J., Zhang, Z. W., Shi, H., Huang, C., Pan, J., & Xie, P. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154550 · Cited by 51 · see citing works
Emsell, L., Langan, C., Hecke, W. V., Barker, G. J., Leemans, A., Sunaert, S. G., McCarthy, P., Nolan, R., Cannon, D. M., & McDonald, C. (2013) · Bipolar Disorders · doi:10.1111/bdi.12073 · Cited by 49 · see citing works
Brain‐derived neurotrophic factor and inflammatory markers in school‐aged children with early trauma
Bücker, J., Fries, G. R., Kapczinski, F. P., Post, R. M., Yatham, L. N., Vianna, P., Chies, J. A. B., Gama, C. S., Magalhães, P. V. D. S., de Aguiar, B. W., et al. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12358 · Cited by 48 · see citing works
Self-citationBarichello, T., Generoso, J. S., Milioli, G., Galvão-Elias, S., & Teixeira, A. L. (2013) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.11.003 · Cited by 47 · see citing works
The Effects of Add-On Low-Dose Memantine on Cytokine Levels in Bipolar II Depression
Lee, S.-Y., Chen, S., Chang, Y.-H., Chen, P. S., Huang, S., Tzeng, N., Wang, Y., Wang, L., Lee, I. H., Wang, T., et al. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000109 · Cited by 46 · see citing works
Rios, A. C., Maurya, P. K., Pedrini, M., Zeni‐Graiff, M., Asevedo, E. D. M., Mansur, R. B., Wieck, A., Grassi‐Oliveira, R., McIntyre, R. S., Hayashi, M. A. F., et al. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0001 · Cited by 45 · see citing works
Self-citationOsete, J. R., Akkouh, I. A., Ievglevskyi, O., Vandenberghe, M., de Assis, D. R., Ueland, T., Kondratskaya, E., Holen, B., Szabó, A., Hughes, T., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01944-0 · Cited by 48 · see citing works
Nichols, C. D. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/475108 · Cited by 43 · see citing works
Biomarkers and staging of bipolar disorder: a systematic review
Roda, Â., Chendo, I., & Kunz, M. (2014) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2014-0002 · Cited by 43 · see citing works
Kim, Y., Zhang, Y., Pang, K., Kang, H., Park, H., Lee, Y., Lee, B., Lee, H., Kim, W.-K., Geum, D., et al. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.6.296 · Cited by 43 · see citing works
Association of biomarkers and depressive symptoms in schizophrenia
Noto, C. D. S., Gadelha, A., Belangero, S. I., Smith, M. D. A. C., de Aguiar, B. W., Panizzutti, B., Mari, J. D. J., Gama, C. S., Bressan, R. A., & Brietzke, E. M. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.042 · Cited by 42 · see citing works
Self-citationLee, S., Chen, S., Chang, Y.-H., Chen, P. S., Huang, S., Tzeng, N., Wang, Y., Wang, L., Lee, I. H., Wang, T.-Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066847 · Cited by 41 · see citing works
Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia
Noto, C. D. S., Gadelha, A., Belangero, S. I., Spíndola, L., Rocha, N. P., de Miranda, A. S., Teixeira, A. L., Smith, M. D. A. C., Mari, J. D. J., Bressan, R. A., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.010 · Cited by 41 · see citing works
Self-citationGaleone, A., Paparella, D., Colucci, S. C., Grano, M., & Brunetti, G. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/875363 · Cited by 40 · see citing works
Hori, H., Yoshimura, R., Katsuki, A., Atake, K., Igata, R., Konishi, Y., & Nakamura, J. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1212172 · Cited by 39 · see citing works
Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression
Noto, C. D. S., Rizzo, L. B., Mansur, R. B., McIntyre, R. S., Maes, M. H. J., & Brietzke, E. M. (2014) · NeuroImmunoModulation · doi:10.1159/000356549 · Cited by 38 · see citing works
Self-citationBipolar disorder in youth is associated with increased levels of vitamin D-binding protein
Petrov, B., Aldoori, A., James, C. L., Yang, K., Algorta, G. P., Lee, A., Zhang, L., Lin, T., Awadhi, R. A., Parquette, J. R., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0109-7 · Cited by 39 · see citing works
Therapeutic potential of interleukin-6 antagonism in bipolar disorder
Brietzke, E. M., Scheinberg, M. A., & Lafer, B. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.08.021 · Cited by 38 · see citing works
Self-citationDysregulation of the NF-κB pathway as a potential inducer of bipolar disorder
Elhaik, E., & Zandi, P. P. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.08.009 · Cited by 37 · see citing works
Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders
Jung, Y. J., Tweedie, D., Scerba, M. T., Kim, D. S., Palmas, M. F., Pisanu, A., Carta, A. R., & Greig, N. H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.656921 · Cited by 36 · see citing works
Dunjić-Kostić, B., Jašović‐Gašić, M., Ivković, M., Radonjić, N. V., Pantović-Stefanović, M., Damjanović, A., Poznanović, S. T., Jovanović, A., Nikolić, T., & Petronijević, N. (2013) · PubMed · Cited by 37 · see citing works
Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
Prossin, A. R., Yolken, R. H., Kamali, M., Heitzeg, M. M., Kaplow, J. B., Coryell, W. H., & McInnis, M. G. (2015) · Neural Plasticity · doi:10.1155/2015/939780 · Cited by 36 · see citing works
Selek, S., Altındağ, A., Saraçoğlu, G., & Aksoy, N. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.058 · Cited by 34 · see citing works
Dacquino, C., Rossi, P. D., & Spalletta, G. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.02.029 · Cited by 34 · see citing works
Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder
Fries, G. R., Vasconcelos-Moreno, M. P., Gubert, C., Tietbohl-Santos, B., da Rosa, A. L. S. T., Eisele, B. S., Sartori, J., Pfaffenseller, B., Kapczinski, F. P., & Kauer‐Sant’Anna, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.027 · Cited by 34 · see citing works
Self-citationGlial cells as key elements in the pathophysiology and treatment of bipolar disorder
Keshavarz, M. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.56 · Cited by 34 · see citing works
Donma, M. M., & Donma, O. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.02.008 · Cited by 33 · see citing works
Millett, C. E., Harder, J., Locascio, J. J., Shanahan, M., Santone, G., Fichorova, R. N., Corrigan, A., Baecher‐Allan, C., & Burdick, K. E. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.003 · Cited by 32 · see citing works
Teixeira, A. L., Souza, R. T. D. A., Zanetti, M. V., Brunoni, A. R., Busatto, G. F., Zarate, C. A., Gattaz, W. F., & Machado‐Vieira, R. (2015) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2450 · Cited by 32 · see citing works
Early life stress and tumor necrosis factor superfamily in crack cocaine withdrawal
Levandowski, M. L., Viola, T. W., Wearick‐Silva, L. E., Wieck, A., Tractenberg, S. G., Brietzke, E. M., Bauer, M. E., Teixeira, A. L., & Grassi‐Oliveira, R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.02.017 · Cited by 31 · see citing works
Self-citationThe association between systemic lupus erythematosus and bipolar disorder – a big data analysis
Tiosano, S., Nir, Z., Gendelman, O., Comaneshter, D. S., Amital, H., Cohen, A. D., & Amital, D. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.03.006 · Cited by 31 · see citing works
Gomes, J. A. D. S., de Souza, G. C., Berk, M., Cavalcante, L. M., de Sousa, F. C. F., Budni, J., de Lucena, D. F., Quevedo, J., Carvalho, A. F., & Macêdo, D. S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.005 · Cited by 30 · see citing works
Cetin, T., Gülöksüz, S., Çetin, E. A., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-158 · Cited by 30 · see citing works
Reconsidering the Association Between the Major Histocompatibility Complex and Bipolar Disorder
Figueiredo, T. C., & de Oliveira, J. R. M. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9656-6 · Cited by 29 · see citing works
Turhan, L., Batmaz, S., Koçbıyık, S., & Soygur, A. H. (2016) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2015.1122079 · Cited by 29 · see citing works
Han, L., Wang, L., Tang, S., Yuan, L., Wu, S., Du, X., Xiang, Y., Qu, X., Liu, H., Luo, H., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1283-5 · Cited by 28 · see citing works
Hsu, J.-W., Lirng, J., Wang, S., Lin, C.-L., Yang, K., Liao, M., & Chou, Y. H. (2013) · Bipolar Disorders · doi:10.1111/bdi.12164 · Cited by 27 · see citing works
Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study
Bitan, D. T., Berzin, D., & Cohen, A. D. (2020) · Dermatology · doi:10.1159/000504535 · Cited by 26 · see citing works
Thillard, E.-M., Gautier, S., Babykina, E., Carton, L., Amad, A., Bouzillé, G., Beuscart, J., & Chazard, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00513 · Cited by 26 · see citing works
Is there a role for curcumin in the treatment of bipolar disorder?
Brietzke, E. M., Mansur, R. B., Zugman, A., Carvalho, A. F., Macêdo, D. S., Cha, D. S., Abílio, V. C., & McIntyre, R. S. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.02.001 · Cited by 24 · see citing works
Self-citationHu, L., Kawamoto, E. M., Brietzke, E. M., Scavone, C., & Lafer, B. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.031 · Cited by 24 · see citing works
Self-citationOsteoprotegerin levels in patients with severe mental disorders
Hope, S., Melle, I. S., Aukrust, P., Agartz, I., Lorentzen, S., Steen, N. E., Djurovic, S., Ueland, T., & Andreassen, O. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090088 · Cited by 24 · see citing works
New Pharmacologic Approaches to the Treatment of Bipolar Depression
Keramatian, K., Chakrabarty, T., DuBow, A., Saraf, G., & Yatham, L. N. (2023) · Drugs · doi:10.1007/s40265-023-01872-x · Cited by 21 · see citing works
Glymphatic system dysfunction in mood disorders: Evaluation by diffusion magnetic resonance imaging
Ueda, R., Yamagata, B., Niida, R., Hirano, J., Niida, A., Yamamoto, Y., & Mimura, M. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.026 · Cited by 20 · see citing works
Biomarkers and detection methods of bipolar disorder
Hu, X., Yu, C., Dong, T., Yang, Z., Fang, Y., & Jiang, Z. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114842 · Cited by 20 · see citing works
Defective Nitric Oxide–Cyclic Guanosine Monophosphate Signaling in Patients With Bipolar Disorder
Fontoura, P. C., Pinto, V. L. M., Matsuura, C., Resende, Â. C., de Bem, G. F., Ferraz, M. R., Cheniaux, E., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182689460 · Cited by 20 · see citing works
Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders
Leite, J. A., Orellana, A. M., Kinoshita, P. F., de Mello, N. P., Scavone, C., & Kawamoto, E. M. (2017) · InTech eBooks · doi:10.5772/intechopen.69343 · Cited by 19 · see citing works
Induction of manic switch by the tumour necrosis factor‐α antagonist infliximab
Elisa, B., & Lafer, B. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02096.x · Cited by 19 · see citing works
Leptin Is Associated with Mood Status and Metabolic Homeostasis in Patients with Bipolar Disorder
Lee, H. J., Kim, S. H., Kim, E. Y., Lee, N. Y., Yu, H. Y., Kim, Y. S., & Ahn, Y. M. (2014) · Neuropsychobiology · doi:10.1159/000366488 · Cited by 18 · see citing works
Oshima, Y., Watanabe, T., Endo, S., Hata, S., Watanabe, T., Osada, K., & Takenaka, A. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1403888 · Cited by 17 · see citing works
Lee, S.-Y., Wang, T., Chen, S., Chang, Y., Chen, P. S., Huang, S., Tzeng, N., Wang, L., Lee, I. H., Chen, K. C., et al. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13640 · Cited by 17 · see citing works
Maes, M. H. J., Rachayon, M., Jirakran, K., Sodsai, P., Klinchanhom, S., Gałecki, P., & Sughondhabirom, A. (2022) · medRxiv · doi:10.1101/2022.02.22.22271319 · Cited by 17 · see citing works
Neuroinflammation and excitatory symptoms in bipolar disorder
Sani, G., Panaccione, I., & Spalletta, G. (2015) · Neuroimmunology and Neuroinflammation · doi:10.4103/2347-8659.167304 · Cited by 17 · see citing works
Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats
Barichello, T., Milioli, G., Generoso, J. S., Cipriano, A. L., da Costa, C. S., Moreira, A. P., Vilela, M. C., Comim, C. M., Teixeira, A. L., & Quevedo, J. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0749-8 · Cited by 15 · see citing works
- Authors
- Brietzke, E., & Kapczinski, F.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Kapczinski, Flávio
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 32
- Issue
- 6
- Pages
- 1355-1361
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2003038736
- Cited by
- 163
- References
- 58
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 18 · 2012: 8
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- TNF-α, bipolar disorder, neuroinflammation, inflammatory cytokines, apoptosis, neuroplasticity, neuronal survival, manic and depressive episodes, serum TNF-α levels, therapeutic target
- MeSH terms
- Animals, Bipolar Disorder, Cell Survival, Cognition Disorders, Humans, Tumor Necrosis Factor-alpha, Cytokines, NF-kappa B, Apoptosis, Antimanic Agents, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review