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Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8
Abstract
To study the role of the metabotropic glutamate receptor 8 (mGluR8), mice lacking this receptor were generated by homologous recombination. Homozygous mGluR8-deficient mice are about 8% heavier than their wild-type age-matched controls after reaching 4 weeks of age. This weight difference is not caused by an altered food intake and is not exacerbated by feeding the animals a high-fat diet. Moreover, mGluR8-/- mice are mildly insulin resistant, possibly as a result of being overweight. Behavioral testing revealed a reduced locomotor activity of mGluR8-/- mice compared with wild-type mice during the first 3 days in a novel enclosed environment. However after 3 days, the locomotor activities of wild-type and mGluR8-/- mice were similar, suggesting a reduced exploratory behavior of mGluR8-/- mice in a novel enclosed environment. By contrast, there were no genotype differences in locomotor activity in the open field, plus maze, or in total time spent exploring objects during object recognition tests, indicating that there is a dissociation between effects of mGluR8 deficiency in exploratory activity in a novel safe enclosed environment vs. a more anxiogenic novel open environment. The absence of mGluR8 also leads to increased measures of anxiety in the open field and elevated plus maze. Whether the diverse phenotypic differences observed in mGluR8-/- mice result from the misregulation of a unique neural pathway, possibly in the thalamus or hypothalamus, or whether they are the consequence of multiple developmental and functional alterations in synaptic transmission, remains to be determined.
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“Mice lacking the Group III receptor subunit GRM8 (mGluR8) display increased age-and sex-dependent anxiety-like behaviors and startle response (Duvoisin et al., 2005(Duvoisin et al., , 2010)).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Duvoisin et al., 2005
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Metadata
- Authors
- Duvoisin, R. M., Zhang, C., Pfankuch, T. F., O'Connor, H., Gayet‐Primo, J., Quraishi, S., & Raber, J.
- Affiliations
- Oregon Health & Science University (US)
- Cornell University (US)
- Oregon National Primate Research Center (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 22
- Issue
- 2
- Pages
- 425-436
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1894780092
- Cited by
- 102
- References
- 57
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 8
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- National Institute on Aging (R01AG020904, AG20904)
- National Eye Institute (R01EY009534, EY09534)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anxiety, weight gain, obesity, insulin resistance, locomotor activity, exploratory behavior, novel environment, object recognition, thalamus, hypothalamus, synaptic transmission
- MeSH terms
- Age Factors, Animals, Anxiety, Avoidance Learning, Behavior, Animal, Blood Glucose, Body Composition, Drug Tolerance, Eating, Exploratory Behavior, Genotype, Insulin, Molecular Biology, Motor Activity, Psychomotor Performance, Reaction Time, Research Design, Time Factors, Blotting, Western, Weight Gain, Absorptiometry, Photon, Receptors, Metabotropic Glutamate, Mice, Knockout, Maze Learning, Recognition, Psychology, Mice
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