The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Interactions and competition within the microbial community of the human colon: links between diet and health
Open accessAbstract
Summary: The microbiota of the human intestinal tract play an important role in health, in particular by mediating many of the effects of diet upon gut health. Surveys of 16S rRNA sequence diversity in the human colon have emphasized the low proportion of sequences that match cultured bacterial species. This may reflect limited recent effort on cultivation rather than inherent unculturability, however, as anaerobic isolation methods can apparently recover a wide range of the diversity found. A combination of information from representative cultures, molecular tools for enumeration and tracking of bacterial metabolites offers the most powerful route to understanding the roles played by different groups of bacteria in the gut ecosystem. Progress is being made for example in defining key functional groups including primary colonizers of insoluble dietary substrates, and major contributors to metabolites such as butyrate that influence the health of the gut mucosa. There is increasing evidence that bacterial populations in the large intestine respond to changes in diet, in particular to the type and quantity of dietary carbohydrate. A general consequence of increased carbohydrate consumption is to reduce the pH of the gut lumen, which is likely to play a major role in determining bacterial metabolism and competition. Oligosaccharides used as dietary prebiotics must inevitably have complex effects upon the bacterial community that include non‐target organisms and the consequences of metabolic cross‐feeding and changes in the gut environment.
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Citations
Cites
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“Microscopy has provided some evidence for the formation of surface-associated communities on mucosal surfaces in the colon, particularly in disease states such as inflammatory bowel disease (IBD) (Macfarlane et al., 2004; Swidsinski et al., 2005).”
BackgroundBelenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. E., & Flint, H. J. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.5.3593-3599.2006 · Cited by 856
Self-citationWalker, A. W., Duncan, S. H., McWilliam Leitch, E. C., Child, M. W., & Flint, H. J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.3692-3700.2005 · Cited by 796
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Selective colonization of insoluble substrates by human faecal bacteria
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Self-citationCultivable bacterial diversity from the human colon
Duncan, S. H., Louis, P., & Flint, H. J. (2007) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2007.02129.x · Cited by 279
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“, 2007) and degradation of mucin (Hoskins, 1993) but the phylogenetic distribution of these attributes is not yet fully established.”
Background
Cited by
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540
Influence of diet on the gut microbiome and implications for human health
Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599
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Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331
Self-citation
Metadata
- Authors
- Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P.
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2007-03-28
- Volume
- 9
- Issue
- 5
- Pages
- 1101-1111
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2037833069
- Cited by
- 635
- References
- 14
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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