Cultivable bacterial diversity from the human colon
Abstract
Knowledge of the composition of the colonic microbiota is important for our understanding of how the balance of these microbes is influenced by diet and the environment, and which bacterial groups are important in maintaining gut health or promoting disease. Molecular methodologies have advanced our understanding of the composition and diversity of the colonic microbiota. Importantly, however, it is the continued isolation of bacterial representatives of key groups that offers the best opportunity to conduct detailed metabolic and functional studies. This also permits bacterial genome sequencing which will accelerate the linkage to functionality. Obtaining new human colonic bacterial isolates can be challenging, because most of these are strict anaerobes and many have rather exact nutritional and physical requirements. Despite this many new species are being isolated and described that occupy distinct niches in the colonic microbial community. This review focuses on these under-studied yet important gut anaerobes.
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Members of the Lachnospiraceae family, such as the Roseburia, Blautia, and Coprococcus genera, are known to break down carbohydrates into short-chain fatty acids (SCFAs).
“Members of the Lachnospiraceae family, such as the Roseburia, Blautia, and Coprococcus genera, are known to break down carbohydrates into short-chain fatty acids (SCFAs) [72].”
From Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptom: a randomized controlled study (2020) · cites this paper as [72]
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- Authors
- Duncan, S. H., Louis, P., & Flint, H. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Duncan, S.H.
- Venue
- Letters in Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 44
- Issue
- 4
- Pages
- 343-350
- ISSN
- 0266-8254 (ISSN-L)
- 1472-765X
- OpenAlex
- W2044219890
- Cited by
- 279
- References
- 51
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 14 · 2023: 19 · 2022: 25 · 2021: 21 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 13 · 2015: 15 · 2014: 12 · 2013: 15 · 2012: 12
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Letters in Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- colonic microbiota, human gut bacteria, anaerobic bacteria, bacterial isolation, bacterial diversity, gut health, diet and gut microbiota, bacterial genome sequencing, gut microbiota
- MeSH terms
- Anaerobiosis, Archaea, Bacteria, Colon, Feces, Humans, Biodiversity
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