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Metabolism of Linoleic Acid by Human Gut Bacteria: Different Routes for Biosynthesis of Conjugated Linoleic Acid

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Devillard, Estelle, McIntosh, Freda M., Duncan, Sylvia H., Wallace, R. John·2007·Journal of Bacteriology
DOI 10.1128/jb.01359-06PMC PMC1899373
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Abstract

A survey of 30 representative strains of human gram-positive intestinal bacteria indicated that Roseburia species were among the most active in metabolizing linoleic acid ( cis -9, cis- 12-18:2). Different Roseburia spp. formed either vaccenic acid ( trans- 11-18:1) or a 10-hydroxy-18:1; these compounds are precursors of the health-promoting conjugated linoleic acid cis- 9, trans- 11-18:2 in human tissues and the intestine, respectively.

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  • PUFAs prevent alteration of the gut microbiota.

    “PUFAs have also been shown to prevent alteration of the gut microbiota (Devillard et al., 2007).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Devillard et al., 2007

    The Abstract (page not provided) describes how human gut bacteria metabolize linoleic acid, not whether PUFAs prevent changes to the gut microbiota. Searches for prevention of microbiota alteration and for effects of polyunsaturated fatty acids on microbial composition found no passage establishing the claimed protective effect. (LLM, conf=0.72)

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Cited by

Sorted by citations

Authors
Devillard, E., McIntosh, F. M., Duncan, S. H., & Wallace, R. J.
Affiliations
Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, United Kingdom
ORCID
Venue
Journal of Bacteriology
Publisher
American Society for Microbiology
Published
2007-03-15
Volume
189
Issue
6
Pages
2566-2570
ISSN
  • 0021-9193 (ISSN-L)
  • 1098-5530
DOI
10.1128/jb.01359-06
PMC
PMC1899373
OpenAlex
W2126468651
Cited by
285
References
0
Citations by year
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FWCI
9.91
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Bacteriology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
linoleic acid metabolism, Roseburia, gut microbiota, vaccenic acid, human gut microbiome
MeSH terms
Adult, Gram-Positive Bacteria, Humans, Infant, Intestine, Large, Isomerases, Linoleic Acids, Linoleic Acids, Conjugated

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