Cited by 251Gut microbiota and healthClostridium difficile and Clostridium perfringens researchOral microbiology and periodontitis research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis

Scanlan, Pauline D., Shanahan, Fergus, Clune, Yvonne, Collins, John K., O'Sullivan, Gerald C., O'Riordan, Micheal, Holmes, Elaine, Wang, Yulan, Marchesi, Julian R.·2008·Environmental Microbiology

DOI 10.1111/j.1462-2920.2007.01503.x

Open this paper in CoChat — free account

Abstract

Summary: A role for the intestinal microbiota is routinely cited as a potential aetiological factor in colorectal cancer initiation and progression. As the majority of bacteria in the gut are refractory to culture we investigated this ecosystem in subjects with colorectal cancer and with adenomatous polyposis who are at high risk of developing colorectal cancer, using culture‐independent methods. Twenty colorectal cancer and 20 polypectomized volunteers were chosen for this analysis. An exploration of the diversity and temporal stability of the dominant bacteria and several bacterial subgroups was undertaken using 16S rRNA gene denaturing gradient gel electrophoresis and ribosomal intergenic spacer analysis (RISA). Metabonomic analysis of the distal gut microbiota's environment was also undertaken. A significantly reduced temporal stability and increased diversity for the microbiota of subjects with colorectal cancer and polyposis was evident. A significantly increased diversity of the Clostridium leptum and C. coccoides subgroups was also noted for both disease groups. A clear division in the metabonome was observed for the colorectal cancer and polypectomized subjects compared with control volunteers. The intestinal microbiota and their metabolites are significantly altered in both colorectal cancer and polypectomized subjects compared with controls.

Integrity signals

Registry

Crossref · 10.1111/j.1462-2920.2007.01503.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Biodiversity and ecosystem functioning: Current knowledge and future challenges
Loreau, M., Naeem, S., Inchausti, P., Bengtsson, J., Grime, J. P., Hector, A., Hooper, D. U., Huston, M. A., Raffaelli, D., Schmid, B., et al. (2001) · Science · doi:10.1126/science.1064088 · Cited by 4,649
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 2×
“The majority (~90%) of colorectal cancers arise sporadically in a time-dependent manner through adenomatous polyp formation with the activation of oncogenes such as K-ras (Lengauer et al., 1998) and inactivation of tumour suppressor genes such as APC and p53 (Hope et al.”
Background
MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
Bax, A., & Davis, D. G. (1985) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(85)90018-6 · Cited by 3,605
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490
Sequence heterogeneities of genes encoding 16S rRNAs in Paenibacillus polymyxa detected by temperature gradient gel electrophoresis
Nübel, U., Engelen, B., Felske, A., Snaidr, J., Wieshuber, A., Amann, R., Ludwig, W., & Backhaus, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5636-5643.1996 · Cited by 1,356
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320

Show all 47 references

Sorted by citations

Items 101–200 of 251

Altered intestinal microbiota associated with colorectal cancer
Zhang, H., Chang, Y., Zheng, Q., Zhang, R., Hu, C., & Jia, W. (2019) · Frontiers of Medicine · doi:10.1007/s11684-019-0695-7 · Cited by 54
Metabolomics: Towards Understanding Host–Microbe Interactions
Han, J., Antunes, L. C. M., Finlay, B. B., & Borchers, C. H. (2010) · Future Microbiology · doi:10.2217/fmb.09.132 · Cited by 51
Systematic review: Gut microbiota in fecal samples and detection of colorectal neoplasms
Amitay, E. L., Krilavičiūtė, A., & Brenner, H. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1445957 · Cited by 56
Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach
Aw, W., & Fukuda, S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0456-2 · Cited by 48
Structural and compositional mismatch between captive and wild Atlantic salmon ( Salmo salar ) parrs’ gut microbiota highlights the relevance of integrating molecular ecology for management and conservation methods
Lavoie, C., Courcelle, M., Redivo, B., & Derôme, N. (2018) · Evolutionary Applications · doi:10.1111/eva.12658 · Cited by 48
“…confers to its host (Bäckhed, Ley, Sonnenburg, Peterson, & Gordon, 2005; Balcazar et al., 2007; Chabrillon et al., 2005; Gaboriau- Routhiau et al., 2009; Rawls, Samuel, & Gordon, 2004; Scanlan et al., 2008; Stappenbeck, Hooper, & Gordon, 2002; Sylvain & Derome, 2017; Tremaroli & Bäckhed, 2012).”
Background
Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
Yang, P., Wang, Z., Peng, Q., Lian, W., & Chen, D. (2021) · Evolutionary Bioinformatics · doi:10.1177/11769343211057573 · Cited by 47
Diet, Gut Microbiota, and Colorectal Cancer Prevention: a Review of Potential Mechanisms and Promising Targets for Future Research
Song, M., & Chan, A. T. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0389-y · Cited by 50
Modulation of gut microbiota in healthy rats after exposure to nutritional supplements
Čoklo, M., Maslov, D. R., & Pavelić, S. K. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1779002 · Cited by 47
Host-bacteria interaction in inflammatory bowel disease
Knight, P., Campbell, B. J., & Rhodes, J. M. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn038 · Cited by 45
Web of ecological interactions in an experimental gut microbiota
Trosvik, P., Rudi, K., Strætkvern, K. O., Jakobsen, K. S., Næs, T., & Stenseth, N. C. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02236.x · Cited by 43
Doxycycline induces dysbiosis in female C57BL/6NCrl mice
Boynton, F. D. D., Ericsson, A. C., Uchihashi, M., Dunbar, M. L., & Wilkinson, J. E. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2960-7 · Cited by 40
“colorectal cancer [1, 2], inflammatory bowel disease [3, 4], rheumatoid arthritis [5]) and animal models (e.”
Background
A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Wang, L., Wang, Y., Li, H., Feng, X., Yuan, D., & Yang, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00684 · Cited by 42
Self-citation
Inflammation in sporadic colorectal cancer.
Moossavi, S., & Bishehsari, F. (2012) · PubMed · Cited by 41
Healthy effects of prebiotics and their metabolites against intestinal diseases and colorectal cancer
Fernández, J., Redondo-Blanco, S., Miguélez, E. M., Villar, C. J., Clemente, A., & Lombó, F. (2015) · AIMS Microbiology · doi:10.3934/microbiol.2015.1.48 · Cited by 41
Predicting the associations between microbes and diseases by integrating multiple data sources and path-based HeteSim scores
Fan, C., Lei, X., Guo, L., & Zhang, A. (2018) · Neurocomputing · doi:10.1016/j.neucom.2018.09.054 · Cited by 39
Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Tarashi, S., Siadat, S. D., Badi, S. A., Zali, M. R., Biassoni, R., Ponzoni, M., & Moshiri, A. (2019) · Microorganisms · doi:10.3390/microorganisms7110561 · Cited by 39
“Gut bacteria Author PublishedTime Enrolment Time Country Sample Type (S/Ta) Cancer Type Method Bifidobacterium Nugent [103] 2014 - USA T CRA qPCR Bilophila Feng [90] 2015 2010–2012 Austria S A-CRA/CRC Metagenomic Shotgun Sequencing Hale [104] 2017 2001–2005 USA S CRA 16S rDNA Sequencing Hibberd [105] 2017 - USA T Colo…”
Background
Non-surgical Periodontal Treatment Restored the Gut Microbiota and Intestinal Barrier in Apolipoprotein E−/− Mice With Periodontitis
Huang, Y., Liao, Y., Luo, B., Li, L., Zhang, Y., & Yan, F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00498 · Cited by 38
Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome
Yu, L.-M., Zhao, K.-J., Wang, S., Wang, X., & Lü, B. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i8.894 · Cited by 37
Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study
Wijeyesekera, A., Clarke, P. A., Bictash, M., Brown, I., Fidock, M. D., Ryckmans, T., Yap, I. K. S., Chan, Q. M., Stamler, J., Elliott, P., et al. (2011) · Analytical Methods · doi:10.1039/c1ay05427a · Cited by 39
Self-citation
Metabolic networks of the human gut microbiota
Selber‐Hnatiw, S., Sultana, T., Tse, W., Abdollahi, N., Abdullah, S., Rahbani, J. A., Alazar, D., Alrumhein, N. J., Aprikian, S., Arshad, R., et al. (2019) · Microbiology · doi:10.1099/mic.0.000853 · Cited by 38
The association between colorectal cancer and prior antibiotic prescriptions: case control study
Armstrong, D., Dregan, A., Ashworth, M. J., White, P. T., McGee, C., & de Lusignan, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0701-5 · Cited by 39
Optimizing the analysis of human intestinal microbiota with phylogenetic microarray
Rigsbee, L., Agans, R., Foy, B. D., & Paliy, O. (2010) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2010.01009.x · Cited by 35
“Among such communities, intestinal bacteria have received special attention due to their hypothesized role in several gastrointestinal disorders such as inflammatory bowel disease, obesity, and colon cancer (van Nuenen et al., 2004; Turnbaugh et al., 2006; Scanlan et al., 2008).”
Background
Effects of Early Intervention with Maternal Fecal Microbiota and Antibiotics on the Gut Microbiota and Metabolite Profiles of Piglets
Lin, C., Wan, J., Su, Y., & Zhu, W. (2018) · Metabolites · doi:10.3390/metabo8040089 · Cited by 34
“For example, in Scanlan’s comparison of colon cancer patients with normal individuals, the diversity of Clostridium coccoides and Clostridium leptum in the former is significantly higher than that of the latter [28].”
Background
Tools for stools: the challenge of assessing human intestinal microbiota using molecular diagnostics
Brugère, J., Mihajlovski, A., Missaoui, M., & Peyret, P. (2009) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.09.16 · Cited by 35
SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer
Howell, M., Green, R. J., McGill, A. R., Dutta, R., Mohapatra, S., & Mohapatra, S. S. (2021) · Cancers · doi:10.3390/cancers13112676 · Cited by 35
“Dysbiosis of the gut microbiota can influence immune status, carcinogenesis, and tumor progression in CRC [37,38].”
Background
Effects of microcystin-LR on gut microflora in different gut regions of mice
Chen, J., Xie, P., Lin, J., He, J., Zeng, C., & Chen, J. (2015) · The Journal of Toxicological Sciences · doi:10.2131/jts.40.485 · Cited by 34
Colorectal Cancer Microenvironment: Among Nutrition, Gut Microbiota, Inflammation and Epigenetics
Garagnani, P., Pirazzini, C., & Franceschi, C. (2012) · Current Pharmaceutical Design · doi:10.2174/1381612811306040765 · Cited by 38
“[126] Scanlan PD, Shanahan F, Clune Y, et al.”
Background
The Guts of Dietary Habits
Gophna, U. (2011) · Science · doi:10.1126/science.1213799 · Cited by 31
The Microbiome and Its Implications in Cancer Immunotherapy
Choudhry, H. (2021) · Molecules · doi:10.3390/molecules26010206 · Cited by 31
Alterations in co-abundant bacteriome in colorectal cancer and its persistence after surgery: a pilot study
Png, C. W., Chua, Y. K., Law, J.-H., Zhang, Y., & Tan, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-14203-z · Cited by 29
A novel non-invasive colorectal cancer diagnostic method: Volatile organic compounds as biomarkers
Alustiza, M., Ripoll, L., Canals, A., Murcia, Ó., Martínez‐Roca, A., García‐Heredia, A., Giner-Calabuig, M., Jover, R., & Vidal, L. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117273 · Cited by 32
Intestinal Ischemia/Reperfusion Injury: Defining the Role of the Gut Microbiome
Kinross, J. K., Warren, O. J., Basson, S., Holmes, E. C., Silk, D. B. A., Darzi, A. W., & Nicholson, J. K. (2009) · Biomarkers in Medicine · doi:10.2217/bmm.09.11 · Cited by 27
Self-citation
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O’Sullivan, G. C., O'Riordan, M., Holmes, E. C., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01622.x · Cited by 29
Self-citation
Infectious Causes of Colorectal Cancer
Hasan, N., Pollack, A. H., & Cho, I. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.009 · Cited by 28
Next generation sequencing and a new era of medicine
Casey, G., Conti, D. V., Haile, R. W., & Duggan, D. J. (2012) · Gut · doi:10.1136/gutjnl-2011-301935 · Cited by 28
Effect of gut microbiota in the colorectal cancer and potential target therapy
Li, J., Zhu, Y., Yang, L., & Wang, Z. (2022) · Discover Oncology · doi:10.1007/s12672-022-00517-x · Cited by 29
“analyzed the fecal flora with CRC and colorectal polyps separately and observed an increased number of Clostridium globosa and Clostridium tenderis [14].”
Background
Transit Time Affects the Community Stability ofLactobacillusandBifidobacteriumSpecies in anIn VitroModel of Human Colonic Microbiotia
Rodes, L., Paul, A., Coussa-Charley, M., Al‐Salami, H., Tomaro-Duchesneau, C., Fakhoury, M., & Prakash, S. (2011) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199.2011.622280 · Cited by 27
“However, an alteration in the composition of the gut microbiota, a state called dysbiosis, is linked with the development of a plethora of human diseases such as infl ammatory bowel diseases [3,4], the irritable bowel syndrome [5,6] and colorectal cancer [7,8].”
Background
Human microbiome versus food-borne pathogens: friend or foe
Josephs‐Spaulding, J., Beeler, E., & Singh, O. V. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7523-7 · Cited by 27
“In another study, IBS patients revealed high levels of bacteriumClostridium coccoides, which is positively associated with colorectal cancer and polyp growth, and Ruminococcus productus as compared to the control group (Scanlan et al. 2008).”
ILSI Brazil International Workshop on Functional Foods: a narrative review of the scientific evidence in the area of carbohydrates, microbiome, and health
Latulippe, M. E., Méheust, A., Augustin, L. S. A., Benton, D., Berčík, P., Birkett, A. M., Eldridge, A. L., Faintuch, J., Hoffmann, C., Jones, J. M., et al. (2013) · Food & Nutrition Research · doi:10.3402/fnr.v57i0.19214 · Cited by 24
“A distinct pattern can also be observed in the same body site according to health and disease state such as inflammatory bowel disease (129), obesity (130), and colon cancer (131).”
Background
Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer
Yang, Y., Nirmagustina, D. E., Kumrungsee, T., Okazaki, Y., Tomotake, H., & Katô, N. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1343117 · Cited by 25
Optimization of GC/TOF MS analysis conditions for assessing host-gut microbiota metabolic interactions: Chinese rhubarb alters fecal aromatic amino acids and phenol metabolism
Yin, S., Guo, P. F., Hai, D., Xu, L., Shu, J., Zhang, W., Khan, M. I., Kurland, I. J., Qiu, Y., & Liu, Y. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.09.042 · Cited by 25
Gut microbiota: an Indicator to Gastrointestinal Tract Diseases
Patel, T., Bhattacharya, P., & Das, S. (2016) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-016-9820-x · Cited by 26
Microbial functionality in the human intestinal tract
Salonen, A. (2009) · Frontiers in bioscience · doi:10.2741/3436 · Cited by 23
“The metabolic profiles of fecal water obtained from healthy controls and subjects having either inflammatory bowel disease (70) or colon cancer (71) were significantly different, the most prominent feature of patients’ profiles being a depletion of SCFAs or an increase of amino acids, respectively.”
Background
The Role of Gut Microbiota in Gastrointestinal Tract Cancers
Grochowska, M., Perlejewski, K., Laskus, T., & Radkowski, M. (2022) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-021-00641-6 · Cited by 20
Progress in the Study of Colorectal Cancer Caused by Altered Gut Microbiota After Cholecystectomy
Ma, Y., Qu, R., Zhang, Y., Jiang, C., Zhang, Z., & Fu, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.815999 · Cited by 23
Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma
Henry, C. J., Sedjo, R. L., Rozhok, A. I., Salstrom, J. L., Ahnen, D. J., Levin, T. R., D’Agostino, R., Haffner, S. M., DeGregori, J. V., & Byers, T. (2015) · BMC Cancer · doi:10.1186/s12885-015-1115-2 · Cited by 19
“More recently, variations in immune cell populations and changes in the gut microbiome have been linked to CRC induction and progression [3,14-20].”
Background
Design, synthesis and in vitro evaluation of anticancer and antibacterial potential of surface modified Tb(OH) 3 @SiO 2 core–shell nanoparticles
Khan, S., Ansari, A. A., Khan, A. A., Al-Kattan, W., Al-Obeed, O. A., & Ahmad, R. (2016) · RSC Advances · doi:10.1039/c5ra17906h · Cited by 19
The Role of the Intestinal Microbiome on Colorectal Cancer Pathogenesis and its Recurrence Following Surgery
Vigneswaran, J., & Shogan, B. D. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04694-4 · Cited by 20
“The development of technologies in the early 2000s for high-throughput sequencing (next generation sequencing) and culture-independent methods for microbial profiling (16S rRNA sequencing and metagenomics) has allowed for a more comprehensive examination of microbial communities that was previously not possible.(4,5)…”
Human Metabolic Phenotyping and Metabolome Wide Association Studies
Holmes, E. C., & Nicholson, J. K. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_096 · Cited by 18
Self-citation
Monitoring intestinal microbiota profile: A promising method for the ultraearly detection of colorectal cancer
Zhang, M.-M., Cheng, J., Xia, L., Lu, Y., & Wu, X. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.01.028 · Cited by 17
“Metabonomic analysis of the gut microbiota reveals that the intestinal microbiota and its metabolites are significantly altered in both colorectal cancer and polypectomized subjects compared with the control groups [17].”
Background
The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging
Chaudhary, S., Kaur, P., Singh, T. A., Bano, K. S., Vyas, A., Mishra, A. K., Singh, P., & Mehdi, M. M. (2024) · Biogerontology · doi:10.1007/s10522-024-10146-2 · Cited by 17
Samples and techniques highlighting the links between obesity and microbiota
Angelakis, E., & Lagier, J. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.024 · Cited by 16
Gut microbiome in colorectal cancer: metagenomics from bench to bedside
Esfahani, A. T., Zafarjafarzadeh, N., Vakili, F., Bizhanpour, A., Mashaollahi, A., Kordestani, B. K., Baratinamin, M., & Mohammadpour, S. (2025) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaf026 · Cited by 15
Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis
Culpepper, B. S. T., & Mai, V. (2012) · Current Nutrition Reports · doi:10.1007/s13668-012-0032-0 · Cited by 16
“Increased diversity in the Clostridium coccoides and Clostridium leptum groups has been observed in CRC patients compared with healthy controls [71].”
Background
Influence of diet and dietary nanoparticles on gut dysbiosis
Jiang, Z., Jacob, J. A., Jian-yue, L., Wu, X., Wei, G., Arunprasanna, V., Mani, R., Nainangu, P., Rajadurai, U. M., & Chen, B. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.03.017 · Cited by 15
Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Lin, X., Zhao, R., & Du, X. (2022) · BMC Nephrology · doi:10.1186/s12882-022-02797-5 · Cited by 15
“flora is related to various diseases, such as inflammatory bowel disease [7,8], obesity [9], diabetes [10, 11], rheumatoid arthritis [12], atopic manifestations [13], liver sclerosis [14], cardiovascular disease [15], mental disease [16, 17], colorectal cancer [18, 19], and chronic kidney disease.”
Background
The gastric mucosal-associated microbiome in patients with gastric polyposis
Ren, R., Wang, Z., Sun, H., Gao, X., Sun, G., Peng, L., Yan, B., & Yang, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-31738-2 · Cited by 15
Intestinal Microbes, Diet, and Colorectal Cancer
Vipperla, K., & O’Keefe, S. J. (2013) · Current Colorectal Cancer Reports · doi:10.1007/s11888-012-0158-x · Cited by 15
“cancer populations have reported interesting associations, but results have not yet revealed a consistent and specific pattern of association of any particular microbial group with CRC [40, 41].”
Background
Impact of Fruit Dietary Fibers and Polyphenols on Modulation of the Human Gut Microbiota
Quirós-Sauceda, A. E., Pacheco‐Ordaz, R., Ayala-Zavala, J. F., Hernández‐Mendoza, A., González-Córdova, A. F., Vallejo‐Galland, B., & González-Aguilar, G. A. (2017) · Wiley eBooks · doi:10.1002/9781119158042.ch19 · Cited by 15
The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in ApcMin mice
Moskowitz, J. E., Andreatta, F., & Amos-Landgraf, J. M. (2019) · Mammalian Genome · doi:10.1007/s00335-019-09814-3 · Cited by 14
“The GM was initially identified as an important factor through associative studies, where investigators linked depletion or enrichment of certain taxa to disease status (Ohigashi et al. 2013; Scanlan et al. 2008).”
Background
Dietary Barley Leaf Mitigates Tumorigenesis in Experimental Colitis-Associated Colorectal Cancer
Li, D., Feng, Y., Tian, M., Hu, X., Zheng, R., & Chen, F. (2021) · Nutrients · doi:10.3390/nu13103487 · Cited by 14
Gut and oral microbial compositional differences in women with breast cancer, women with ductal carcinoma in situ , and healthy women
McCune, E., Sharma, A., Johnson, B., O’Meara, T. A., Theiner, S., Campos, M., Heditsian, D. M., Brain, S., Gilbert, J. A., Esserman, L. J., et al. (2024) · mSystems · doi:10.1128/msystems.01237-24 · Cited by 17
“Alterations in these microbial communities have been linked to a variety of diseases, including inflammatory bowel disease (7, 8), obesity (9), diabetes (10, 11), rheumatoid arthritis (12), cardiovascular diseases (13), and cancer (14–20).”
SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
Mozaffari, S. A., Salehi, A., Mousavi, E., Zaman, B. A., Nassaj, A. E., Ebrahimzadeh, F., Nasiri, H., Valedkarimi, Z., Adili, A., Asemani, G., et al. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154131 · Cited by 13
Understanding the Extent and Sources of Variation in Gut Microbiota Studies; a Prerequisite for Establishing Associations with Disease
Mai, V., Ukhanova, M., & Baer, D. J. (2010) · Diversity · doi:10.3390/d2091085 · Cited by 14
“Colorectal adenomas are not necessarily good surrogate markers for CRC risk, only 10% of polyps are thought to have the potential to proceed to CRC. CRC is a relatively rare disease that can develop after decades of exposure to risk factors that might include distorted microbiota diversity or as of yet unknown pathoge…”
BackgroundInfluential
An Integrated Outlook on the Metagenome and Metabolome of Intestinal Diseases
Aw, W., & Fukuda, S. (2015) · Diseases · doi:10.3390/diseases3040341 · Cited by 15
Need for Prospective Cohort Studies to Establish Human Gut Microbiome Contributions to Disease Risk
Mai, V., & Morris, J. G. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt349 · Cited by 13
“Increased diversity in the Clostridium coccoides and Clostridium leptum groups has previously been reported from CRC patients (20), in contrast with the Ahn et al.”
The role of intestinal microbiota in the pathogenesis of colorectal carcinoma
Kuzma, J., Chmelař, D., Hájek, M., Lochmanová, A., Ciznar, I., Rozložník, M., & Klugar, M. (2019) · Folia Microbiologica · doi:10.1007/s12223-019-00706-2 · Cited by 11
“Carcinogenic change of the intestinal wall is induced by the production of phenols and indole, conversion of bile acids on carcinogens, and production of hydrogen sulfide, azoreductases, nitro compounds, and ROS (Scanlan et al. 2008).”
BackgroundInfluential
Processing Matters in Nutrient-Matched Laboratory Diets for Mice—Microbiome
Wenderlein, J., Böswald, L. F., Ulrich, S., Kienzle, E., Neuhaus, K., Lagkouvardos, I., Zenner, C., & Straubinger, R. K. (2021) · Animals · doi:10.3390/ani11030862 · Cited by 12
“Shifts in the composition of the microbiota may lead to dysbiosis in the gut, resulting in pathological processes [14] and can lead to gastrointestinal disorders, such as inflammatory bowel disease [15,16] and malignancies [17,18].”
Background
Probiotics in the Rescue of Gut Inflammation
Ghosh, A. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814625-5.00006-6 · Cited by 10
Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints
Keane, J. M., Walsh, C. J., Cronin, P., Baker, K., Melgar, S., Cotter, P. D., Joyce, S. A., Gahan, C. G. M., Houston, A. M., & Hyland, N. P. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02062-4 · Cited by 9
“However, studies have also reported an increase in α-diversity in patients with colon cancer [32, 33].”
Background
Microbiote et cancer colorectal : des bactéries génotoxiques dans le tractus intestinal
Nougayrède, J., & Oswald, É. (2011) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)31989-2 · Cited by 9
TLR signaling: a link between gut microflora, colorectal inflammation and tumorigenesis
Santaolalla, R., Sussman, D. A., & Abreu, M. T. (2011) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2012.02.002 · Cited by 8
Health and environmental applications of gut microbiome: a review
Chatterjee, S., Datta, S., Sharma, S., Tiwari, S., & Gupta, D. K. (2017) · Ecological Chemistry and Engineering S · doi:10.1515/eces-2017-0032 · Cited by 8
“Apart from genetic components, based on numerous clinical/epidemiological studies and experimental animal models it has been proposed that gut microbiota may contribute to the development of colorectal cancer (CRC) through exposure of the gut mucosa to the microflora and their metabolites [79].”
Influential
Application of Systems Biology in the Research of TCM Formulae
Yan, S., Nagle, D. G., Zhou, Y., & Zhang, W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812744-5.00003-5 · Cited by 9
Predictive Values of Colon Microbiota in the Treatment Response to Colorectal Cancer
Ros, J. G., Ramos-Arenas, V., & Conesa‐Zamora, P. (2020) · Pharmacogenomics · doi:10.2217/pgs-2020-0044 · Cited by 9
Exploring Gut Microbiome Composition and Circulating Microbial DNA Fragments in Patients with Stage II/III Colorectal Cancer: A Comprehensive Analysis
Messaritakis, I., Koulouris, A., Boukla, E., Vogiatzoglou, K., Lagkouvardos, I., Intze, E., Sfakianaki, M., Chondrozoumaki, M., Karagianni, M., Athanasakis, E., et al. (2024) · Cancers · doi:10.3390/cancers16101923 · Cited by 7
“The correlation between cancer and microbiota has been evidenced across diverse organs [5,6].”
Background
MAPLE: A Microbiome Analysis Pipeline Enabling Optimal Peptide Search and Comparative Taxonomic and Functional Analysis
Huang, W., & Kane, M. A. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00114 · Cited by 7
Shaping the human microbiome with prebiotic foods – current perspectives for continued development
Tuohy, K. M., Brown, D. T., Klinder, A., & Costabile, A. (2010) · Food Science & Technology Bulletin Functional Foods · doi:10.1616/1476-2137.15989 · Cited by 8
Influence of neo-adjuvant radiotherapy on the intestinal microbiota of rectal cancer patients
Xu, S., Lv, Q., Zou, N., Zhang, Y., Zhang, J., Tang, Q., Chou, S., Li, L., & He, J. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04553-6 · Cited by 6
Compositional dynamics of the human intestinal microbiota with aging: Implications for health
Lakshminarayanan, B., Stanton, C., O’Toole, P. W., & Ross, R. P. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0513-5 · Cited by 7
Exploring Human Bacterial Diversity Toward Prevention of Infectious Disease and Health Promotion
Yousuf, B., & Mishra, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814849-5.00029-0 · Cited by 5
Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer
Keane, J. M., Joyce, S. A., Gahan, C. G. M., Hyland, N. P., & Houston, A. M. (2020) · Results and problems in cell differentiation · doi:10.1007/978-3-030-51849-3_22 · Cited by 5
ARZIMM: A Novel Analytic Platform for the Inference of Microbial Interactions and Community Stability from Longitudinal Microbiome Study
He, L., Wang, C., Hu, J., Gao, Z., Falcone, E. L., Holland, S. M., Blaser, M. J., & Li, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.777877 · Cited by 4
“While 51 temporally stable microbial communities are observed among healthy adults [1], the 52 fluctuation of microbiome has been linked to increasing frailty [2] and declining immune 53 function of hosts [3], and diseases such as inflammatory bowel disease [4, 5], colorectal 54 cancer [6, 7], and irritable bowel synd…”
Background
Gut Microbiota-targeted, Whole-Body Systems Biology for Understanding Traditional Chinese Medicine
Zhang, X., Zhao, Y., Hu, Y., Liu, P., & Liping, Z. (2011) · World Science and Technology · doi:10.1016/s1876-3553(12)60007-6 · Cited by 6
Metagenomic Study of Human Gastrointestinal Tracts in Health and Diseases
Abbasian, F., & Saberbaghi, T. (2013) · Journal of Gastroenterology and Hepatology Research · Cited by 3
Emerging Trends of Biotechnology in Marine Bioprospecting: A New Vision
Jain, A., & Tailor, V. (2020) · Springer eBooks · doi:10.1007/978-981-15-5017-1_1 · Cited by 3
Gut microbial ecology
Flint, H. J., Duncan, S. H., & Louis, P. (2009) · Elsevier eBooks · doi:10.1533/9781845696603.1.38 · Cited by 4
Role of Gut Microbiota in Pathogenesis and Treatment of Type 2 Diabetes
Duggal, N., & Kapoor, S. (2021) · Eurasian Journal of Medicine and Oncology · doi:10.14744/ejmo.2021.56223 · Cited by 2
“The imbalance or dysbiosis can cause various disease conditions or can exacerbate the severity of diseases such as ulcerative colitis, crohn's disease, inflammatory bowel disease, colorectal cancer food allergy and non-alcoholic steatohepatitis.[6-14] In addition, intestinal microbiota (IM) changes have also been link…”
Background
Fish cancer and its assistance to human cancer research: A fresh perspective
Dan, H., Wang, W., Chen, X., Goda, M. N., Kishta, M. S., & Cao, Q. (2025) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2025.110369 · Cited by 2
Intestinal Host-Microbiome Interactions
Tjalsma, H., & Boleij, A. (2012) · InTech eBooks · doi:10.5772/30225 · Cited by 2
“It can be envisaged that bacterial TLR4 ligands, such as LPS, play an important role in this increased chemotactic activity of tumor cells (Scanlan et al., 2008).”
The Microbiota: A New Player in the Etiology of Colorectal Cancer
Levy, M., Thaiss, C. A., & Elinav, E. (2013) · Current Colorectal Cancer Reports · doi:10.1007/s11888-013-0196-z · Cited by 3
Using metabolomics to analyse the role of gut microbiota in nutrition and disease
Xie, G., & Jia, W. P. (2014) · Elsevier eBooks · doi:10.1016/b978-1-78242-084-2.00006-x · Cited by 2
The Role of Integrated Omics in Elucidating the Gut Microbiota Health Potentials
Aw, W., & Fukuda, S. (2015) · Microbiology monographs · doi:10.1007/978-3-319-23213-3_4 · Cited by 2
Clinical Characteristic of Young Indonesian Colorectal Cancer Patients: A Preliminary Study
Lugito, N. P. H. (2018) · Medicinus · doi:10.19166/med.v5i3.1171 · Cited by 2
“A culturedependent study of the microbiota of patients with polyps and CRC identified 15 bacterial taxa significantly associated with high risk of colon cancer (including species of Bacteroides, Eubacterium, and Bifidobacterium) and five associated with low risk of colon cancer (including species of Lactobacillus).(13)”
Background
Microbial Diversity and Their Role in Human Health and Diseases
Bhat, M. H., Hajam, Y. A., Neelam, N., Kumar, R., & Diksha, D. (2023) · Springer eBooks · doi:10.1007/978-981-99-3126-2_1 · Cited by 2
The gut microbiome and colorectal cancer
Dietz, M. A., Subramanian, S., & Staley, C. M. (2026) · Clinical Microbiology Reviews · doi:10.1128/cmr.00332-25 · Cited by 1
“In the past two decades, researchers have begun investigating the composition of the gut microbiome as a possible factor in CRC initiation and progression (38).”
Rôle des génotoxines produites par des bactéries du microbiote dans le cancer colorectal
Petit, C. R., Oswald, É., & Nougayrède, J. (2013) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(13)72226-3 · Cited by 1
“[17] Scanlan PD, Shanahan F, Clune Y, et al.”
Background
Microbes, Oxytocin, and Healthful longevity
Erdman, S. E. (2014) · Journal of Probiotics & Health · doi:10.4172/2329-8901.1000117 · Cited by 1
“Substantial indirect support also exists in scientific and epidemiological studies interconnecting microbes with systemic health [1-4,10-22].”
Background
Epigenetic Effects of Gut Microbiota on Obesity and Gastrointestinal Cancers
Kuroiwa‐Trzmielina, J., & Hesson, L. B. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41610-6_7 · Cited by 1
Intestinal microbiota around colorectal cancer genesis
Brandi, G., Rosa, F. D., Liguori, G., Agostini, V., Girolamo, S. D., Gaboriau‐Routhiau, V., Raibaud, P., & Biasco, G. (2013) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · Cited by 1

Authors: Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R.
Affiliations: University College Cork (IE)
Imperial College London (GB)
Corresponding author: Marchesi, Julian R.
ORCID: Scanlan, Pauline D.
Shanahan, Fergus
Collins, John K.
Holmes, Elaine
Wang, Yulan
Marchesi, Julian R.
Venue: Environmental Microbiology
Publisher: Wiley
Published: 2008-01-25
Volume: 10
Issue: 3
Pages: 789-798
ISSN: 1462-2912 (ISSN-L)
1462-2920
DOI: 10.1111/j.1462-2920.2007.01503.x
OpenAlex: W2146480823
Cited by: 245
References: 47
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 20 · 2017: 13 · 2016: 17 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 12
FWCI: 6.96
Type: journal article
Language: en
Update notices: erratum (2008-04-04)
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Environmental Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
Higher Education Authority
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, colorectal cancer, adenomatous polyposis, polypectomy, microbial diversity, temporal stability, Clostridium leptum, Clostridium coccoides, 16S rRNA gene, RISA, metabolomics, cancer etiology
MeSH terms: Clostridium, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Female, Humans, Intestines, Male, Adenomatous Polyposis Coli, RNA, Ribosomal, 16S, Colorectal Neoplasms, DNA, Ribosomal Spacer, Gastrointestinal Tract, Biodiversity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks