The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Abstract
Summary: A role for the intestinal microbiota is routinely cited as a potential aetiological factor in colorectal cancer initiation and progression. As the majority of bacteria in the gut are refractory to culture we investigated this ecosystem in subjects with colorectal cancer and with adenomatous polyposis who are at high risk of developing colorectal cancer, using culture‐independent methods. Twenty colorectal cancer and 20 polypectomized volunteers were chosen for this analysis. An exploration of the diversity and temporal stability of the dominant bacteria and several bacterial subgroups was undertaken using 16S rRNA gene denaturing gradient gel electrophoresis and ribosomal intergenic spacer analysis (RISA). Metabonomic analysis of the distal gut microbiota's environment was also undertaken. A significantly reduced temporal stability and increased diversity for the microbiota of subjects with colorectal cancer and polyposis was evident. A significantly increased diversity of the Clostridium leptum and C. coccoides subgroups was also noted for both disease groups. A clear division in the metabonome was observed for the colorectal cancer and polypectomized subjects compared with control volunteers. The intestinal microbiota and their metabolites are significantly altered in both colorectal cancer and polypectomized subjects compared with controls.
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“An increased diversity in Clostridium leptum (C.leptum) and Clostridium coccoides is present, while temporary instability and decreased complexity in composition are linked to colitis-associated CRC [48,49] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [48]
In the citing paper
“Reduced temporal stability and increased diversity has been shown for the faecal microbiota of subjects with established CRC and polyposis,86”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [86]
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Additional file 3 of Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Xi, L., Zhao, R., & Du, X. (2022) · Figshare · doi:10.6084/m9.figshare.19687015
Additional file 2 of Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Xi, L., Zhao, R., & Du, X. (2022) · Figshare · doi:10.6084/m9.figshare.19687012
Additional file 5 of Association of gut microbiota with idiopathic membranous nephropathy
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Additional file 1 of Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Xi, L., Zhao, R., & Du, X. (2022) · Figshare · doi:10.6084/m9.figshare.19687009
Additional file 6 of Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Xi, L., Zhao, R., & Du, X. (2022) · Figshare · doi:10.6084/m9.figshare.19687024
Additional file 4 of Association of gut microbiota with idiopathic membranous nephropathy
Li, M., Wei, L., Sun, J., Zhu, Q., He, Y., Zhang, Y., Zhang, C., Xi, L., Zhao, R., & Du, X. (2022) · Figshare · doi:10.6084/m9.figshare.19687018
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Background
Metadata
- Authors
- Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R.
- Affiliations
- University College Cork (IE)
- Imperial College London (GB)
- Corresponding author
- Marchesi, Julian R.
- ORCID
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2008-01-25
- Volume
- 10
- Issue
- 3
- Pages
- 789-798
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2146480823
- Cited by
- 245
- References
- 47
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 20 · 2017: 13 · 2016: 17 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 12
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-04-04)
- Open access
- closed
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- Higher Education Authority
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, colorectal cancer, adenomatous polyposis, polypectomy, microbial diversity, temporal stability, Clostridium leptum, Clostridium coccoides, 16S rRNA gene, RISA, metabolomics, cancer etiology
- MeSH terms
- Clostridium, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Female, Humans, Intestines, Male, Adenomatous Polyposis Coli, RNA, Ribosomal, 16S, Colorectal Neoplasms, DNA, Ribosomal Spacer, Gastrointestinal Tract, Biodiversity
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